{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:43:49Z","timestamp":1765075429307,"version":"3.46.0"},"reference-count":24,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1976,6]]},"abstract":"<jats:p>Mast cells have been counted in iliac bone biopsies from patients with chronic renal failure treated by haemodialysis, and attempts made to relate mast cells to the various features of azotaemic renal osteodystrophy. There was a significant increase in the number of marrow mast cells in comparison with controls, and haemodialysis has no favourable effect on the marrow mast cell hyperplasia which occurs in chronic renal failure. There was a general tendency towards greater numbers of mast cells in cases with most marked ostetis fibrosa but it was not possible consistently to relate hyperparathyroidism to mast cell numbers. Patients treated by parathyroidectomy, aluminium hydroxide, or the newer vitamin D metabolites failed to show any consistent fall in marrow mast cell numbers in spite of improvement in the ostetis fibrosa. The number of marrow mast cells was related to the duration of haemodialysis and to the amount of osteoid present and iversely to the percentage mineralization of bone. It was not possible to identify any causal relationship between the presence or severity of osteomalacia and the number of mast cells in the haemodialysed patients although mast cell hyperplasia was also observed in patients with osteomalacia unassociated with renal disease.<\/jats:p>","DOI":"10.1136\/jcp.29.6.502","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"502-516","source":"Crossref","is-referenced-by-count":21,"title":["Iliac bone marrow mast cells in relation to the renal osteodystrophy of patients treated by haemodialysis."],"prefix":"10.1136","volume":"29","author":[{"given":"H A","family":"Ellis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K M","family":"Peart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1976,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1136\/bmj.3.5924.150","article-title":"latrogenic osteomalacia and myopathy due to phosphate depletion","volume":"3","author":"Baker, L.R.I.; Ackrill, P.; Cattell, W.R.; Stamp, T.C.B.; Watson, L.","year":"1974","unstructured":"Baker, L. R. I., Ackrill, P., Cattell, W. R., Stamp, T. C. B. and Watson, L. (1974). latrogenic osteomalacia and myopathy due to phosphate depletion. Brit. med. J., 3, 150-152.","journal-title":"Brit. med. J"},{"key":"ref_2","series-title":"Grune and Stratton","first-page":"249","author":"Bordier, P.","year":"1970","unstructured":"Bordier, P. (1970). Discussion of paper by Frame, B., and Nixon, R. K. In Osteoporosis, edited by U. S. Barzel, p. 249. Grune and Stratton, New York and London."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/jama.1975.03260140049013","article-title":"I-a-Hydroxyvitamin D3 in chronic renal failure: a potent analogue of the kidney hormone, 1, 25dihydroxycholecalciferol.","volume":"234","author":"Chan, J.C.M.; Oldham, S.B.; Holick, M.F.; DeLuca, H.F.","year":"1975","unstructured":"Chan, J. C. M., Oldham, S. B., Holick, M. F., and DeLuca, H. F. (1975). I-a-Hydroxyvitamin D3 in chronic renal failure: a potent analogue of the kidney hormone, 1, 25dihydroxycholecalciferol. J. Amer. med. Ass., 234, 47-52.","journal-title":"J. Amer. med. Ass."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0046-8177(74)80114-0","article-title":"Mast cells in the cortical tubular epithelium and interstitium in human renal disease","volume":"5","author":"Colvin, R.B.; Dvorak, A.M.; Dvorak, H.F.","year":"1974","unstructured":"Colvin, R. B., Dvorak, A. M., and Dvorak, H. F. (1974). Mast cells in the cortical tubular epithelium and interstitium in human renal disease. Hum. Path., 5, 315-326.","journal-title":"Hum. Path"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/bmj.3.5873.232-c","article-title":"Bone disease in end-stage renal failure","volume":"3","author":"Ellis, H.A.","year":"1973","unstructured":"Ellis, H. A. (1973). Bone disease in end-stage renal failure. (Letter). Brit. med. 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Nephron, 8, 402.","journal-title":"Nephron"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/jcp.25.4.277","article-title":"Quantitative observations on mineralized and non-mineralized bone in the iliac crest","volume":"25","author":"Ellis, H.A.; Peart, K.M.","year":"1972","unstructured":"Ellis, H. A. and Peart, K. M. (1972). Quantitative observations on mineralized and non-mineralized bone in the iliac crest. J. clin. Path., 25, 277-286.","journal-title":"J. clin. Path"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/jcp.26.2.83","article-title":"Azotaemic renal osteodystrophy: a quantitative study on iliac bone","volume":"26","author":"Ellis, H.A.; Peart, K.M.","year":"1973","unstructured":"Ellis, H. A. and Peart, K. M. (1973). Azotaemic renal osteodystrophy: a quantitative study on iliac bone. J. elin. Path., 26, 83-101.","journal-title":"J. elin. 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