{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:55:21Z","timestamp":1765007721825,"version":"3.46.0"},"reference-count":16,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:p>The value of the beryllium macrophage migration inhibition (Be MIF) and Mantoux tests in the diagnosis of chronic beryllium disease and in the detection of hypersensitivity in healthy beryllium workers is demonstrated. In the absence of steroid treatment the Be MIF test is positive in chronic beryllium disease patients. Seven of 50 (14%) helathy beryllium workers were Be MIF positive, while all the control subjects, normal and sarcoidosis patients, were negative. Healthy beryllium workers tend to be more often Mantoux negative than a comparable group of non-exposed workers, and although not conclusive this finding correlates with a positive Be MIF test. Although the detection of hypersensitivity is not diagnostic of disease, the Be MIF test can be used as an additional method for monitoring the health of beryllium workers. The full significance of our results should be assessed by a long-term study.<\/jats:p>","DOI":"10.1136\/jcp.30.1.24","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"24-28","source":"Crossref","is-referenced-by-count":13,"title":["Role of in vitro and in vivo tests of hypersensitivity in beryllium workers."],"prefix":"10.1136","volume":"30","author":[{"given":"C D","family":"Price","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W J","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D H","family":"Joynson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,1,1]]},"reference":[{"key":"ref_1","first-page":"235","volume-title":"The assay of inhibition of macrophage migration and the production of migraine inhibitory factor (MIF) and skin reactive factor (SRF) in the guinea pig. In In Vitro Methods in Cell Mediated Immunity","author":"Bloom, B.R.; Bennett, B.","year":"1971","unstructured":"Bloom, B. R. and Bennett, B. (1971). The assay of inhibition of macrophage migration and the production of migraine inhibitory factor (MIF) and skin reactive factor (SRF) in the guinea pig. In In Vitro Methods in Cell Mediated Immunity, edited by B. R. Bloom and P. R. Glades, pp. 235-248. Academic Press, New York."},{"key":"ref_2","first-page":"150","article-title":"The diagnosis of beryllium disease with special reference to the patch test","volume":"19","author":"Curtis, G.H.","year":"1959","unstructured":"Curtis, G. H. (1959). The diagnosis of beryllium disease with special reference to the patch test. Arch. industr. Hyg., 19, 150.","journal-title":"Arch. industr. Hyg"},{"key":"ref_3","first-page":"279","article-title":"Delayed hypersensitivity in vitro. III. The specificity of hapten protein conjugates in the inhibition of cell migration","volume":"93","author":"David, J.R.; Lawrence, H.S.; Thomas, L.","year":"1964","unstructured":"David, J. R., Lawrence, H. S., and Thomas, L. (1964). Delayed hypersensitivity in vitro. III. The specificity of hapten protein conjugates in the inhibition of cell migration. J. Immnunol., 93, 279-282.","journal-title":"J. Immnunol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1084\/jem.128.6.1451","article-title":"Immunochemical studies on the specificity of cellular hypersensitivity","volume":"128","author":"David, J.R.; Schlossman, S.F.","year":"1968","unstructured":"David, J. R., and Schlossman, S. F. (1968). Immunochemical studies on the specificity of cellular hypersensitivity. J. exp. Med., 128, 1451-1459.","journal-title":"J. exp. Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1378\/chest.63.3.309","article-title":"A study of the immunologic aspects of chronic berylliosis","volume":"63","author":"Deodhar, S.D.; Barna, B.; van Ordstrand, H.S.","year":"1973","unstructured":"Deodhar, S. D., Barna, B., and van Ordstrand, H. S. (1973). A study of the immunologic aspects of chronic berylliosis. Chest, 63, 309-313.","journal-title":"Chest"},{"key":"ref_6","article-title":"Statistical Method in Biological Assay","author":"Finney, D.J.","year":"1964","unstructured":"Finney, D. J. (1964). Statistical Method in Biological Assay, 2nd ed. Griffin, London.","edition":"2nd ed"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1523-1747.ep13077177","article-title":"In vitro demonstration of delayed hypersensitivity in patients with berylliosis","volume":"58","author":"Henderson, W.R.; Fukuyama, K.; Epstein, W.L.; Spitler, L.E.","year":"1972","unstructured":"Henderson, W. R., Fukuyama, K., Epstein, W. L., and Spitler, L. E. (1972). In vitro demonstration of delayed hypersensitivity in patients with berylliosis. J. invest. Derm., 58, 5-8.","journal-title":"J. invest. Derm"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0022-1759(72)90034-8","article-title":"Macrophage migration inhibition test: a critical examination of the technique using a polythene capillary tubing micromethod","volume":"1","author":"Hughes, D.","year":"1972","unstructured":"Hughes, D. (1972). Macrophage migration inhibition test: a critical examination of the technique using a polythene capillary tubing micromethod. J. Immunol. Meth., 1, 403-424.","journal-title":"J. Immunol. Meth"},{"key":"ref_9","first-page":"636","article-title":"first seven cases of chronic beryllium disease in ceramic workers in Japan","volume":"278","author":"Izumi, T.; Jones Williams, W.","year":"1976","unstructured":"Izumi, T. and Jones Williams, W. (1976).'The first seven cases of chronic beryllium disease in ceramic workers in Japan. Proceedings of the VII International Conference on Sarcoidosis. Ann. N. Y. Acad. Sci. 278, 636.","journal-title":"Proceedings of the VII International Conference on; Sci"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000231120","article-title":"Contact sensitivity in vitro: activation of actively allergized lymphocytes by a beryllium complex","volume":"46","author":"Jones, J.M.; Amos, H.E.","year":"1974","unstructured":"Jones, J. M. and Amos, H. E. (1974). Contact sensitivity in vitro: activation of actively allergized lymphocytes by a beryllium complex. Int. Arch. Allergy, 46, 161-171.","journal-title":"Int. Arch. Allergy"},{"key":"ref_11","first-page":"22","article-title":"Contact sensitivity in vitro. II. The effect of beryllium preparations on the proliferative responses of specifically allergized lymphocytes and normal lymphocytes stimulated with PHA","volume":"48","author":"Jones, J.M.; Amos, H.E.","year":"1975","unstructured":"Jones, J. M. and Amos, H. E. (1975). Contact sensitivity in vitro. II. The effect of beryllium preparations on the proliferative responses of specifically allergized lymphocytes and normal lymphocytes stimulated with PHA. Int. Arch. Allergy, 48, 22-29.","journal-title":"Int. Arch. Allergy"},{"key":"ref_12","article-title":"Diagnosis of chronic beryllium disease (Letter). Brit","author":"Jones Williams, W.; Grey, J.; Pioli, E.M.","year":"1972","unstructured":"Jones Williams, W., Grey, J., and Pioli, E. M. (1972). Diagnosis of chronic beryllium disease (Letter). Brit."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4049\/jimmunol.111.2.590","article-title":"Delayed hypersensitivity to beryllium compounds","volume":"111","author":"Marx, Jr., J.J.; Burrell, R.","year":"1973","unstructured":"Marx, J. J., Jr. and Burrell, R. (1973). Delayed hypersensitivity to beryllium compounds. J. Immunol., 111, 590-598.","journal-title":"J. Immunol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1398-9995.1974.tb01648.x","article-title":"Cell migration inhibition: An appraisal","volume":"29","author":"Morley, J.","year":"1974","unstructured":"Morley, J. (1974). Cell migration inhibition: An appraisal. Acta allerg. (Kbh.), 29, 185-208.","journal-title":"Acta allerg. (Kbh.)"},{"key":"ref_15","first-page":"545","article-title":"Chronic beryllium disease. Long term follow up of 60 cases and selective review of the literature","volume":"46","author":"Stoekle, J.; D., Hardy; L., H.; Weber, A.L.","year":"1969","unstructured":"Stoekle, J.,D., Hardy, H. L., and Weber, A. L. (1969). Chronic beryllium disease. Long term follow up of 60 cases and selective review of the literature. Amner. J. Med., 46, 545.","journal-title":"Amner. J. Med"},{"key":"ref_16","article-title":"Toxicity of Beryllium Compounds","author":"Tepper, L.B.","year":"1961","unstructured":"Tepper, L. B., Hardy, H. L., and Chamberlin, R. I. Eds. (1961). Toxicity of Beryllium Compounds. Elsevier, Amsterdam; Van Nostrand, London."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.30.1.24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:52:13Z","timestamp":1765007533000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.30.1.24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1977,1,1]]},"published-print":{"date-parts":[[1977,1]]}},"alternative-id":["10.1136\/jcp.30.1.24"],"URL":"https:\/\/doi.org\/10.1136\/jcp.30.1.24","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}