{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T16:10:02Z","timestamp":1717171802040},"reference-count":37,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:p>The absorption of xylose following an oral load of 15 g D-xylose has been studied by serial blood levels in 17 untreated adult coeliac patients, 21 treated coeliac patients, and 30 non-coeliac patients. A statistically significant difference in xylose blood levels was found between untreated coeliac and non-coeliac patients at all the times studied, but a complete separation between these two groups occurred only at the 75 minute stage. The reproducibility of absorption was assessed by repeating the test in 16 subjects. The 95% confidence limits of the standard error of estimate are narrowest at 75 and 90 minutes.<\/jats:p>","DOI":"10.1136\/jcp.30.1.76","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T04:50:46Z","timestamp":1181364646000},"page":"76-80","source":"Crossref","is-referenced-by-count":6,"title":["The 15 g D-xylose absorption test: its application to the study of coeliac disease."],"prefix":"10.1136","volume":"30","author":[{"given":"F M","family":"Stevens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D W","family":"Watt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Bourke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"McNicholl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P F","family":"Fottrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C F","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,1,1]]},"reference":[{"key":"ref_1","first-page":"76","article-title":"Morphologic and functional effects of gluten feeding on jejunal mucosa in celiac disease","author":"Bayless, T.M.; Rubin, S.E.; Topping, T.M.; Yardley, J.H.; Hendrix, T.R.","year":"1970","unstructured":"Bayless, T. M., Rubin, S. E., Topping, T. M., Yardley, J. H., and Hendrix, T. R. (1970). Morphologic and functional effects of gluten feeding on jejunal mucosa in celiac disease. In Coeliac Disease, edited by C. C. Booth and R. H. Dowling, pp. 76-89. Churchill Livingstone, Edinburgh and London."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1056\/NEJM195702212560802","article-title":"The D-xylose absorption test in malabsorption syndromes","volume":"256","author":"Benson, Jr., J.A.; Culver, P.J.; Ragland, S.; Jones, C.M.; Drummey, G.D.; Bougas, E.","year":"1957","unstructured":"Benson, J. A., Jr., Culver, P. J., Ragland, S., Jones, C. M., Drummey, G. D., and Bougas, E. (1957). The D-xylose absorption test in malabsorption syndromes. New England Journal of Medicine, 256, 335-339.","journal-title":"New England Journal of Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1136\/bmj.1.5283.985","article-title":"Absorption of folic acid and D-xylose as tests of small-intestinal function","volume":"1","author":"Chanarin, I.; Bennett, M.C.","year":"1962","unstructured":"Chanarin, I. and Bennett, M. C. (1962). Absorption of folic acid and D-xylose as tests of small-intestinal function. British Medical Journal, 1, 985-989.","journal-title":"British Medical Journal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF02283874","article-title":"The simultaneous emptying and absorption of ethanol from the human stomach","volume":"15","author":"Cooke, A.R.","year":"1970","unstructured":"Cooke, A. R. (1970). The simultaneous emptying and absorption of ethanol from the human stomach. American Journal of Digestive Diseases, 15, 449-454.","journal-title":"American Journal of Digestive Diseases"},{"key":"ref_5","first-page":"74","article-title":"Gliadin degradation and fractionation","author":"Cornell, H.J.","year":"1974","unstructured":"Cornell, H. J. (1974). Gliadin degradation and fractionation. In Coeliac Disease, edited by W. T. J. M. Hekkens and A. S. Pena, pp. 74-75. Stenfert Kroese, Leyden."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1136\/gut.15.11.862","article-title":"The toxicity of certain cereal proteins in coeliac disease","volume":"15","author":"Cornell, H.J.; Townley, R.R.W.","year":"1974","unstructured":"Cornell, H. J. and Townley, R. R. W. (1974). The toxicity of certain cereal proteins in coeliac disease. Gut, 15, 862-869.","journal-title":"Gut"},{"key":"ref_7","first-page":"348","article-title":"Intestinal permeability as a screening test for mucosal damage","author":"Creamer, B.","year":"1974","unstructured":"Creamer, B. (1974). Intestinal permeability as a screening test for mucosal damage. In Coeliac Disease, edited by W. T. J. M. Hekkens and A. S. Pena, pp. 348-349. Stenfert Kroese, Leyden."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1651-2227.1953.tb05563.x","article-title":"Coeliac disease 1I. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease","volume":"42","author":"Dicke, W.K.; Weijers, H.A.; van de Kamer, J.H.","year":"1953","unstructured":"Dicke, W. K., Weijers, H. A., and van de Kamer, J. H. (1953). Coeliac disease 1I. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease. Acta Paediatrica, 42, 34-42.","journal-title":"Acta Paediatrica"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1113\/jphysiol.1968.sp008410","article-title":"The slowing of gastric emptying by monosaccharides and disaccharides in test meals","volume":"194","author":"Elias, E.; Gibson, G.J.; Greenwood, L.F.; Hunt, J.N.; Tripp, J.H.","year":"1968","unstructured":"Elias, E., Gibson, G. J., Greenwood, L. F., Hunt, J. N., and Tripp, J. H. (1968). The slowing of gastric emptying by monosaccharides and disaccharides in test meals. Jouirnal of Physiology, 194, 317-326.","journal-title":"Jouirnal of Physiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1056\/NEJM196208092670602","article-title":"Intestinal absorption of D-xylose in man","volume":"267","author":"Fordtran, J.S.; Soergel, K.H.; Ingelfinger, F.J.","year":"1962","unstructured":"Fordtran, J. S., Soergel, K. H., and Ingelfinger, F. J. (1962). Intestinal absorption of D-xylose in man. New England Journal of Medicine, 267, 274-278.","journal-title":"New England Journal of Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0016-5085(19)33738-2","article-title":"Intraluminal small-intestinal utilization of D-xylose by bacteria","volume":"59","year":"1970","unstructured":"Goldstein, F., Karacadag, S., Wirts, C. W., and Kowlessar, 0. D. (1970). Intraluminal small-intestinal utilization of D-xylose by bacteria. Gastroenterology, 59, 380-386.","journal-title":"Gastroenterology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0022-3476(72)80538-9","article-title":"Childhood celiac disease: response of treated patients to a small uniform daily dose of wheat gluten","volume":"81","author":"Hamilton, J.R.; McNeill, L.K.","year":"1972","unstructured":"Hamilton, J. R. and McNeill, L. K. (1972). Childhood celiac disease: response of treated patients to a small uniform daily dose of wheat gluten. Journal of Pediatrics, 81, 885-893.","journal-title":"Journal of Pediatrics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/clinchem\/16.9.749","article-title":"Pediatric xylose absorption test: measurements in blood preferable to measurements in urine","volume":"16","author":"Hawkins, K.","year":"1970","unstructured":"Hawkins, K. 1. (1970). Pediatric xylose absorption test: measurements in blood preferable to measurements in urine. Clinical Chemistry, 16, 749-752.","journal-title":"Clinical Chemistry"},{"key":"ref_14","first-page":"39","article-title":"x Gliadin structure and degradation","author":"Hekkens, W.T.J.M.; van den Aarsen, C.J.; Gilliams, J.P.; Lems-Van Kan, P.H.; Bouma-Frolich, G.","year":"1974","unstructured":"Hekkens, W. T. J. M., van den Aarsen, C. J., Gilliams, J. P., Lems-Van Kan, P. H., and Bouma-Frolich, G. (1974). x Gliadin structure and degradation. In Coeliac Disease, edited by W. T. J. M. Hekkens and A. S Peiia, pp. 39-45. Stenfert Kroese, Leyden."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0016-5085(19)34891-7","article-title":"The duodenal regulation of gastric emptying","volume":"45","author":"Hunt, J.N.","year":"1963","unstructured":"Hunt, J. N. (1963). The duodenal regulation of gastric emptying. Gastroenterology, 45, 149-156.","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1113\/jphysiol.1960.sp006577","article-title":"The osmotic effects of some simple molecules and ions on gastric emptying","volume":"154","author":"Hunt, J.N.; Pathak, J.D.","year":"1960","unstructured":"Hunt, J. N. and Pathak, J. D. (1960). The osmotic effects of some simple molecules and ions on gastric emptying. Journal of Physiology, 154, 254-269.","journal-title":"Journal of Physiology"},{"key":"ref_17","first-page":"138","article-title":"Pentosuria, chronic and alimentary","volume":"20","author":"Johnstone, R.W.","year":"1906","unstructured":"Johnstone, R. W. (1906). Pentosuria, chronic and alimentary. Edinburgh MedicalJournal, 20, 138-148.","journal-title":"Edinburgh MedicalJournal"},{"key":"ref_18","first-page":"1065","article-title":"Gluten subfractions in coeliac disease","volume":"2","author":"Kendall, M.J.; Cox, P.S.; Schneider, R.; Hawkins, C.F.","year":"1972","unstructured":"Kendall, M. J., Cox, P. S., Schneider, R., and Hawkins, C. F. (1972a). Gluten subfractions in coeliac disease. Lancet, 2, 1065-1067.","journal-title":"Lancet"},{"key":"ref_19","first-page":"667668","article-title":"Testing gluten sensitivity by the xylose test","volume":"1","author":"Kendall, M.J.; Nutter, S.; Hawkins, C.F.","year":"1972","unstructured":"Kendall, M. J., Nutter, S., and Hawkins, C. F. (1972b). Testing gluten sensitivity by the xylose test. Lancet, 1. 667668.","journal-title":"Lancet"},{"key":"ref_20","author":"Lamabadusuriya, S.P.; Packer, S.; Harries, J.T.","year":"1975","unstructured":"Lamabadusuriya, S. P., Packer, S., and Harries, J. T. (1975)"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1042\/bj0240795","article-title":"The comparative rates of absorption of sugars from the human intestine","volume":"24","author":"McCance, R.A.; Madders, K.","year":"1930","unstructured":"McCance, R. A., and Madders, K. (1930). The comparative rates of absorption of sugars from the human intestine. Biochemical Journal, 24, 795-804.","journal-title":"Biochemical Journal"},{"key":"ref_22","author":"Meeroff, J.C.; Go, V.L.W.; Phillips, S.F.","year":"1973","unstructured":"Meeroff, J. C., Go, V. L. W., and Phillips, S. F. (1973)."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1042\/bj1260019Pb","article-title":"Alimentary disacchariduria in adults related to the osmolality of ingested solutions","volume":"126","author":"Menzies, 1. S","year":"1972","unstructured":"Menzies, 1. S. (1972a). Alimentary disacchariduria in adults related to the osmolality of ingested solutions. Biochemical Journal, 126, 19-20.","journal-title":"Biochemical Journal"},{"key":"ref_24","first-page":"847","article-title":"Intestinal permeability in coeliac disease (Abstract)","volume":"13","author":"Menzies, I.S.","year":"1972","unstructured":"Menzies, I. S. (1972b). Intestinal permeability in coeliac disease (Abstract). Gut, 13, 847.","journal-title":"Gut"},{"key":"ref_25","first-page":"112","article-title":"D(-T )xylose blood-level time-curve as an index of intestinal absorption with a description of a simplified method for estimation of blood xylose levels","volume":"83","author":"Roberts, J.G.; Beck, I.T.; Kallos, J.; Kahn, D.S.","year":"1960","unstructured":"Roberts, J. G., Beck, I. T., Kallos, J., and Kahn, D. S. (1960). D(-T )xylose blood-level time-curve as an index of intestinal absorption with a description of a simplified method for estimation of blood xylose levels. Canadian Medical Association Journal, 83, 112-117.","journal-title":"Canadian Medical Association Journal"},{"key":"ref_26","article-title":"A photometric method for the determination of free pentoses in animal tissues","author":"Roe, J.H.; Rice, E.W.","year":"1948","unstructured":"Roe, J. H. and Rice, E. W. (1948). A photometric method for the determination of free pentoses in animal tissues."},{"key":"ref_27","first-page":"507","article-title":"Journal ofBiological","volume":"173","unstructured":"Journal ofBiological Chemistry, 173, 507-512.","journal-title":"Chemistry"},{"key":"ref_28","author":"Rolles, C.J.; Anderson, C.M.; McNeish, A.S.","year":"1975","unstructured":"Rolles, C. J., Anderson, C. M., and McNeish, A. S. (1975)."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0140-6736(73)93227-3","article-title":"Gluten provocation and the xylose test in adolescents (Letter)","volume":"2","author":"Rolles, C.J.; Kendall, M.J.","year":"1973","unstructured":"Rolles, C. J., and Kendall, M. J. (1973). Gluten provocation and the xylose test in adolescents (Letter). Lancet, 2, 381.","journal-title":"Lancet"},{"key":"ref_30","first-page":"1043","article-title":"One-hour blood-xylose screening-test for coeliac disease","volume-title":"infants and young children. Lancet","volume":"2","author":"Rolles, C.J.; Kendall, M.J.; Nutter, S.; Anderson, C.M.","year":"1973","unstructured":"Rolles, C. J., Kendall, M. J., Nutter, S., and Anderson, C. M. (1973). One-hour blood-xylose screening-test for coeliac disease in infants and young children. Lancet, 2, 1043-1045."},{"key":"ref_31","author":"Schneider, R.; Kendall, M.J.; Hawkins, C.F.","year":"1974","unstructured":"Schneider, R., Kendall, M. J., and Hawkins, C. F. (1974)."},{"key":"ref_32","first-page":"64","article-title":"The response of the intestinal mucosa to the intraduodenal instillation of gluten in patients with coeliac disease during remission","author":"Booth, Coeliac Diseaseby C.C.; Shmerling, D.H.; Shiner, M.","year":"1970","unstructured":"Shmerling, D. H., and Shiner, M. (1970). The response of the intestinal mucosa to the intraduodenal instillation of gluten in patients with coeliac disease during remission. In Coeliac Disease, edited by C. C. Booth and R. H. Dowling, pp. 64-74. Churchill Livingstone, Edinburgh and London."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/bmj.3.5873.223","article-title":"Is the xylose test still a worth-while investigation?","volume":"3","author":"Sladen, G.E.; Kumar, P.J.","year":"1973","unstructured":"Sladen, G. E., and Kumar, P. J. (1973). Is the xylose test still a worth-while investigation? British Medical Journal, 3, 223-226.","journal-title":"British Medical Journal"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.0954-6820.1962.tb04217.x","article-title":"The D-xylose absorption tolerance test","volume":"171","author":"Thaysen, E.H.; Mullertz, S.","year":"1962","unstructured":"Thaysen, E. H. and Mullertz, S. (1962). The D-xylose absorption tolerance test. Acta Medica Scandinavica, 171, 521-529.","journal-title":"Acta Medica Scandinavica"},{"key":"ref_35","first-page":"1362","article-title":"Toxicity of wheat gliadin fractions in coeliac disease","volume":"1","author":"Townley, R.R.W.; Bhathal, P.S.; Cornell, H.J.; Mitchell, J.D.","year":"1973","unstructured":"Townley, R. R. W., Bhathal, P. S., Cornell, H. J., and Mitchell, J. D. (1973). Toxicity of wheat gliadin fractions in coeliac disease. Lancet, 1, 1362-1364.","journal-title":"Lancet"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/gut.16.2.109","article-title":"Assessment of small bowel function in the elderly using a modified xylose tolerance test","volume":"16","author":"Webster, S.G.P.; Leeming, J.T.","year":"1975","unstructured":"Webster, S. G. P., and Leeming, J. T. (1975). Assessment of small bowel function in the elderly using a modified xylose tolerance test. Gut, 16, 109-113.","journal-title":"Gut"},{"key":"ref_37","first-page":"609","article-title":"The d-xylose tolerance test: a measure of intestinal absorption in normal and dystrophic infants (Abstract)","volume":"90","author":"Wolfish, M.G.; Hildick-Smith, G.J.; Ebbs, J.H.; Connell, M.L.; Sass-Kortsak, A.","year":"1955","unstructured":"Wolfish, M. G., Hildick-Smith, G. J., Ebbs, J. H., Connell, M. L., and Sass-Kortsak, A. (1955). The d-xylose tolerance test: a measure of intestinal absorption in normal and dystrophic infants (Abstract). American Journal of Diseases of Children, 90, 609-610.","journal-title":"American Journal of Diseases of Children"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.30.1.76","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T15:48:48Z","timestamp":1717170528000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.30.1.76"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1977,1,1]]},"published-print":{"date-parts":[[1977,1]]}},"alternative-id":["10.1136\/jcp.30.1.76"],"URL":"https:\/\/doi.org\/10.1136\/jcp.30.1.76","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}