{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:18:02Z","timestamp":1765595882426,"version":"3.48.0"},"reference-count":23,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1977,10]]},"abstract":"<jats:p>We reviewed 18 patients with a clinical diagnosis of dermatitis herpetiformis who were being treated with dapsone and were on an unrestricted diet. Diagnosis was confirmed by finding IgA deposits in the dermal papillae of unaffected skin. Dapsone was discontinued and biopsy of affected skin was carried out when the typical rash reappeared. The biopsy findings were graded according to the severity of the histological changes. Small bowel tissue from each patient was examined and graded by stereo- and routine microscopy. Thirteen specimens (72%) were stereomicroscopically abnormal; all 18 showed villous atrophy, either partial or subtotal; and in 13 (72%) the interepithelial lymphocyte count was increased. No correlation was found between the histological severity of the skin and the small bowel lesions. Seemingly the severity of the skin rash in dermatitis herpetiformis is no guide to the degree of small bowel abnormality.<\/jats:p>","DOI":"10.1136\/jcp.30.10.976","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"976-980","source":"Crossref","is-referenced-by-count":6,"title":["Dermatitis herpetiformis: a comparative assessment of skin and bowel abnormality."],"prefix":"10.1136","volume":"30","author":[{"given":"T","family":"Cooney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C T","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Whelton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0016-5085(71)80114-2","article-title":"The small intestinal mucosa in dermatitis herpetiformis. I. Severity and distribution of the small intestinal lesion and associated malabsorption","volume":"60","author":"Brow, J.R.; Parker, F.; Weinstein, W.M.; Rubin, C.E.","year":"1971","unstructured":"Brow, J. R., Parker, F., Weinstein, W. M., and Rubin, C. E. (1971). The small intestinal mucosa in dermatitis herpetiformis. I. Severity and distribution of the small intestinal lesion and associated malabsorption. Gastroenterology, 60, 355-361.","journal-title":"Gastroenterology"},{"key":"ref_2","first-page":"191","article-title":"Dermatitis herpetiformis: histological discriminants","volume":"58","author":"Connor, B.L.; Marks, R.; Jones, E.W.","year":"1972","unstructured":"Connor, B. L., Marks, R., and Jones, E. W. (1972). Dermatitis herpetiformis: histological discriminants. Transactions of the St. John's Hospital Dermatological Society, 58, 191-198.","journal-title":"Transactions of the St. John's Hospital Dermatological Society"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1136\/gut.12.12.988","article-title":"Quantitation of intraepithelial lymphocytes in human jejunum","volume":"12","author":"Ferguson, A.; Murray, D.","year":"1971","unstructured":"Ferguson, A., and Murray, D. (1971). Quantitation of intraepithelial lymphocytes in human jejunum. Gut, 12, 988-994.","journal-title":"Gut"},{"key":"ref_4","first-page":"729","article-title":"Small-intestinal structure and function and haematological changes in dermatitis herpetiformis","volume":"2","author":"Fry, L.; Keir, P.; McMinn, R.M.H.; Cowan, J.D.; Hoffbrand, A.V.","year":"1967","unstructured":"Fry, L., Keir, P., McMinn, R. M. H., Cowan, J. D., and Hoffbrand, A. V. (1967). Small-intestinal structure and function and haematological changes in dermatitis herpetiformis. Lancet, 2, 729-734.","journal-title":"Lancet"},{"key":"ref_5","first-page":"557","article-title":"Effect of gluten-free diet on dermatological, intestinal, and haematological manifestations of dermatitis herpetiformis","volume":"1","author":"Fry, L.; McMinn, R.M.H.; Cowan, J.D.; Hoffbrand, A.V.","year":"1968","unstructured":"Fry, L., McMinn, R. M. H., Cowan, J. D., and Hoffbrand, A. V. (1968). Effect of gluten-free diet on dermatological, intestinal, and haematological manifestations of dermatitis herpetiformis. Lancet, 1, 557-561.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1001\/archderm.1969.01610260005001","article-title":"Gluten-free diet and reintroduction of gluten in dermatitis herpetiformis","volume":"100","author":"Fry, L.; McMinn, R.M.H.; Cowan, J.D.; Hoffbrand, A.V.","year":"1969","unstructured":"Fry, L., McMinn, R. M. H., Cowan, J. D., and Hoffbrand, A. V. (1969). Gluten-free diet and reintroduction of gluten in dermatitis herpetiformis. Archives of Dermatology, 100, 129-135.","journal-title":"Archives of Dermatology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2133.1974.tb06377.x","article-title":"Dermatitis herpetiformis: an evaluation of diagnostic criteria","volume":"90","author":"Fry, L.; Seah, P.P.","year":"1974","unstructured":"Fry, L., and Seah, P. P. (1974). Dermatitis herpetiformis: an evaluation of diagnostic criteria. British Journal of Dermatology, 90, 137-146.","journal-title":"British Journal of Dermatology"},{"key":"ref_8","first-page":"27","article-title":"The small intestine in dermatitis herpetiformis","author":"Fry, L.; Seah, P.P.; Harper, P.G.; Hoffbrand, A.V.; McMinn, R.M.H.","year":"1974","unstructured":"Fry, L., Seah, P. P., Harper, P. G., Hoffbrand, A. V., and McMinn, R. M. H. (1974). The small intestine in dermatitis herpetiformis. 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Clinical response of dermatitis herpetiformis skin lesions to a gluten-free diet. British Journal of Dermatology, 94, 509-514.","journal-title":"British Journal of Dermatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/gut.17.8.612","article-title":"Coeliac disease, gluten-free diet, and malignancy","volume":"17","author":"Holmes, G.K.T.; Stokes, P.L.; Sorahan, T.M.; Prior, P.; Waterhouse, J.A.H.; Cooke, W.T.","year":"1976","unstructured":"Holmes, G. K. T., Stokes, P. L., Sorahan, T. M., Prior, P., Waterhouse, J. A. H., and Cooke, W. T. (1976). Coeliac disease, gluten-free diet, and malignancy. Gut, 17, 612-619.","journal-title":"Gut"},{"key":"ref_12","article-title":"Pemphigus and Pemphigoid","author":"Lever, W.F.","year":"1965","unstructured":"Lever, W. F. (1965). Pemphigus and Pemphigoid. Thomas, Springfield, Illinois."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/bmj.4.5686.772","article-title":"Results of treatment of dermatitis herpetiformis with a gluten-free diet after one year","volume":"4","author":"Marks, R.; Whittle, M.W.","year":"1969","unstructured":"Marks, R., and Whittle, M. W. (1969). Results of treatment of dermatitis herpetiformis with a gluten-free diet after one year. British Medical Journal, 4, 772-775.","journal-title":"British Medical Journal"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1136\/gut.17.8.600","article-title":"Evaluation of the intraepithelial lymphocyte count in thejejunum in childhood enteropathies","volume":"17","author":"Mavromichalis, J.; Brueton, M.J.; McNeish, A.S.; Anderson, C.M.","year":"1976","unstructured":"Mavromichalis, J., Brueton, M. J., McNeish, A. S., and Anderson, C. M. (1976). Evaluation of the intraepithelial lymphocyte count in thejejunum in childhood enteropathies. Gut, 17, 600-603.","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/bmj.1.5855.703","article-title":"The incidence of coeliac disease in the West of Ireland","volume":"1","author":"Mylotte, M.; Egan-Mitchell, B.; McCarthy, C.F.; McNicholl, B.","year":"1973","unstructured":"Mylotte, M., Egan-Mitchell, B., McCarthy, C. F., and McNicholl, B. (1973). The incidence of coeliac disease in the West of Ireland. British Medical Journal, 1, 703-","journal-title":"British Medical Journal"},{"key":"ref_16","first-page":"\"253","article-title":"The histological diagnosis of dermatitis herpetiformis, bullous pemphigoid and erythema multiforme","volume":"73","author":"Pi6rard, J.; Whimster, I.","year":"1961","unstructured":"Pi6rard, J., and Whimster, I. (1961). The histological diagnosis of dermatitis herpetiformis, bullous pemphigoid and erythema multiforme. British Journal of Dermatology, 73, 253-266. Ruppin, H., Weidner, F., Domschke, S., Domschke, W., Classen, M., and Hornstein, 0. P. (1975). Dermatitis herpetiformis and small intestinal lesion-no strict association in German patients. Acta Hepato-Gastroenterologica, 22, 105-111.","journal-title":"British Journal of Dermatology; Dermatitis herpetiformis and small intestinal lesion-no strict association in German patients"},{"key":"ref_17","article-title":"Patchiness of the mucosal abnormality in coeliac disease (CD) and dermatitis herpetiformis (DH)","volume":"16","author":"Scott, B.B.; Losowsky, M.S.","year":"1975","unstructured":"Scott, B. B., and Losowsky, M. S. (1975). Patchiness of the mucosal abnormality in coeliac disease (CD) and dermatitis herpetiformis (DH). Gut, 16, 393. (Abstract).","journal-title":"Gut"},{"key":"ref_18","first-page":"17","article-title":"Coeliac disease and dermatitis herpetiformis: further studies of their relationship","author":"Scott, B.B.; Young, S.; Rajah, S.M.; Marks, J.; Losowsky, M.S.","year":"1976","unstructured":"Scott, B. B., Young, S., Rajah, S. M., Marks, J., and Losowsky, M. S. (1976). Coeliac disease and dermatitis herpetiformis: further studies of their relationship. Gut, 17,759-762."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1365-2133.1975.tb03052.x","article-title":"Immunoglobulins in the skin in dermatitis herpetiformis and their relevance in diagnosis","volume":"92","author":"Seah, P.P.; Fry, L.","year":"1975","unstructured":"Seah, P. P., and Fry, L. (1975). Immunoglobulins in the skin in dermatitis herpetiformis and their relevance in diagnosis. 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Reticulin antibodies in patients with coeliac disease and their relatives. Gut, 16, 598-602.","journal-title":"Gut"},{"key":"ref_22","article-title":"The small intestinal mucosa in dermatitis herpetiformis","author":"Weinstein, W.M.; Brow, J.R.; Parker, F.; Rubin, C.E.","year":"1970","unstructured":"Weinstein, W. M., Brow, J. R., Parker, F., and Rubin, C. E. (1970). The small intestinal mucosa in dermatitis herpetiformis."},{"key":"ref_23","first-page":"362","article-title":"Relationship of the small intestinal lesion to gluten","volume":"60","unstructured":"Relationship of the small intestinal lesion to gluten. 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