{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:12:35Z","timestamp":1760015555855},"reference-count":28,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1977,12]]},"abstract":"<jats:p>Telangiectasia-associated hepatic fibrosis (TAHF) in a 68-year-old woman with hereditary haemorrhagic telangiectasia (HHT) is described. The patient died of oat-cell carcinoma of the lung. In addition to the structural alterations which have been described previously in HHT, the liver exhibited focal midlobular hepatocytic necrosis and tumour metastases. The possibility that treatment of HHT was causally related to some of the hepatic abnormalities found in our patient and the differentiation of TAHF from true cirrhosis are discussed.<\/jats:p>","DOI":"10.1136\/jcp.30.12.1134","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T04:50:46Z","timestamp":1181364646000},"page":"1134-1141","source":"Crossref","is-referenced-by-count":17,"title":["'Pseudocirrhosis' in hereditary haemorrhagic telangiectasia."],"prefix":"10.1136","volume":"30","author":[{"given":"T","family":"Cooney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E C","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Coll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Greally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1699-0463.1954.tb00877.x","article-title":"On the pathogenesis of hepatic changes in telangiectasia hereditaria haemorrhagica (morbus Osler-Rendu-Weber)","volume":"35","author":"Angervall, L.","year":"1954","unstructured":"Angervall, L. (1954). On the pathogenesis of hepatic changes in telangiectasia hereditaria haemorrhagica (morbus Osler-Rendu-Weber). Acta Pathologica et Microbiologica Scandinavica, 35, 332-338.","journal-title":"Acta Pathologica et Microbiologica Scandinavica"},{"key":"ref_2","first-page":"25","article-title":"Nodular regenerative hyperplasia of the liver in Felty's syndrome","volume":"43","author":"Blendis, L.M.; Parkinson, M.C.; Shilkin, K.B.; Williams, R.","year":"1974","unstructured":"Blendis, L. M., Parkinson, M. C., Shilkin, K. B., and Williams, R. (1974). Nodular regenerative hyperplasia of the liver in Felty's syndrome. Quarterly Journal of Medicine, 43, 25-32.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/S0140-6736(73)92956-5","article-title":"Benign hepatomas and oral contraceptives (Letter)","volume":"2","author":"Contostavlos, D.L.","year":"1973","unstructured":"Contostavlos, D. L. (1973). Benign hepatomas and oral contraceptives (Letter). Lancet, 2, 1200.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1056\/NEJM197602262940904","article-title":"Liver-cell adenomas associated with use of oral contraceptives","volume":"294","author":"Edmondson, H.A.; Henderson, B.; Benton, B.","year":"1976","unstructured":"Edmondson, H. A., Henderson, B., and Benton, B. (1976). Liver-cell adenomas associated with use of oral contraceptives. New England Journal of Medicine, 294, 470-472.","journal-title":"New England Journal of Medicine"},{"key":"ref_5","first-page":"1227","volume-title":"Liver. In Pathology, Vol. 2","author":"Edmondson, H.A.; Peters, R.L.","year":"1971","unstructured":"Edmondson, H. A., and Peters, R. L. (1971). Liver. In Pathology, Vol. 2, 6th Edition, edited by W. A. D. Anderson, pp. 1227-1258.","edition":"6"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0016-5085(19)33250-0","article-title":"Hereditary hemorrhagic telangiectasia presenting with portal hypertension and cirrhosis of the liver","volume":"63","author":"C. V. Mosby, St. Louis. Feizi, 0","year":"1972","unstructured":"C. V. Mosby, St. Louis. Feizi, 0. (1972). Hereditary hemorrhagic telangiectasia presenting with portal hypertension and cirrhosis of the liver. Gastroenterology, 63, 660-664.","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/00000658-196403000-00004","article-title":"Hepatic artery aneurysm with portal vein fistula in a patient with familial hereditary telangiectasia","volume":"159","year":"1964","unstructured":"Graham, W. P. III, Eisman, B., and Pryor, R. (1964). Hepatic artery aneurysm with portal vein fistula in a patient with familial hereditary telangiectasia. Annals of Surgery, 159, 362-367.","journal-title":"Annals of Surgery"},{"key":"ref_8","first-page":"927943","article-title":"Multiple small arteriovenous fistulae of the lungs","volume":"32","author":"Hales, M.R.","year":"1956","unstructured":"Hales, M. R. (1956). Multiple small arteriovenous fistulae of the lungs. American Journal of Pathology, 32, 927943.","journal-title":"American Journal of Pathology"},{"key":"ref_9","first-page":"783","article-title":"Angiodysplasias of the abdominal viscera associated with hereditary haemorrhagic telangiectasia","volume":"102","author":"Halpern, M.; Turner, A.F.; Citron, B.P.","year":"1968","unstructured":"Halpern, M., Turner, A. F., and Citron, B. P. (1968). Angiodysplasias of the abdominal viscera associated with hereditary haemorrhagic telangiectasia. American Journal of Roentgenology, 102, 783-789.","journal-title":"American Journal of Roentgenology"},{"key":"ref_10","first-page":"25","article-title":"Familial haemorrhagic telangiectasia. 20 cases treated with systemic oestrogen","volume":"33","author":"Harrison, D.F.N.","year":"1964","unstructured":"Harrison, D. F. N. (1964). Familial haemorrhagic telangiectasia. 20 cases treated with systemic oestrogen. Quarterly Journal of Medicine, 33, 25-38.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_11","series-title":"Proceedings of the World Congress of Gastroenterology and the Fiftyninth Meeting of the American Gastroenterological Association","first-page":"857","article-title":"Cirrhosis of the liver in hereditary haemorrhagic telangiectasia","volume":"2","author":"Martini, G.A.","year":"1959","unstructured":"Martini, G. A. (1959). Cirrhosis of the liver in hereditary haemorrhagic telangiectasia. In Proceedings of the World Congress of Gastroenterology and the Fiftyninth Meeting of the American Gastroenterological Association, Vol. 2, pp. 857-858. Williams and Wilkins Co., Baltimore."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/ajcp\/61.6.735","article-title":"Focal nodular hyperplasia of the liver","volume":"61","author":"Mays, E.T.; Christopherson, W.M.; Barrows, G.H.","year":"1974","unstructured":"Mays, E. T., Christopherson, W. M., and Barrows, G. H. (1974). Focal nodular hyperplasia of the liver. American Journal of Clinical Pathology, 61, 735-746.","journal-title":"American Journal of Clinical Pathology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0016-5085(68)80167-2","article-title":"Hepatic telangiectases and portosystemic encephalopathy in Osler-Weber-Rendu disease","volume":"54","author":"Michaeli, D.; Ben-Bassat, I.; Miller, H.I.; Deutsch, V.","year":"1968","unstructured":"Michaeli, D., Ben-Bassat, I., Miller, H. I., and Deutsch, V. (1968). Hepatic telangiectases and portosystemic encephalopathy in Osler-Weber-Rendu disease. Gastroenterology, 54, 929-932.","journal-title":"Gastroenterology"},{"key":"ref_14","first-page":"284","article-title":"Peliosis hepatis: Possible etiologic role of anabolic steroids","volume":"95","author":"Naeim, F.; Copper, P.H.; Semion, A.A.","year":"1973","unstructured":"Naeim, F., Copper, P. H., and Semion, A. A. (1973). Peliosis hepatis: Possible etiologic role of anabolic steroids. Archives ofPathology, 95, 284-285.","journal-title":"Archives ofPathology"},{"key":"ref_15","first-page":"2489","article-title":"Hereditare hamorrhagische Teleangiektasie (Morbus Osler). Bericht uiber 24 Patienten, insbes uber deren Leberbefunde","volume":"3","author":"Pietschmann, H.; Kolarz, G.","year":"1969","unstructured":"Pietschmann, H., and Kolarz, G. (1969). Hereditare hamorrhagische Teleangiektasie (Morbus Osler).Bericht uiber 24 Patienten, insbes uber deren Leberbefunde. Miinchener Medizinische Wochenschrift, 3, 2489-2493.","journal-title":"Miinchener Medizinische Wochenschrift"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0002-9343(71)90189-6","article-title":"Hyperdynamic circulatory state due to intrahepatic fistula in OslerWeber-Rendu disease","volume":"50","author":"Razi, B.; Beller, B.M.; Ghidoni, J.; Linhart, J.W.; Talley, R.C.; Urban, E.","year":"1971","unstructured":"Razi, B., Beller, B. M., Ghidoni, J., Linhart, J. W., Talley, R. C., and Urban, E. (1971). Hyperdynamic circulatory state due to intrahepatic fistula in OslerWeber-Rendu disease. American Journal of Medicine, 50, 809-815.","journal-title":"American Journal of Medicine"},{"key":"ref_17","first-page":"39","article-title":"The rarity of intrahepatic metastasis in cirrhosis of the liver","volume":"ofPathology,","author":"Abbey, H.","year":"1961","unstructured":"Abbey, H. (1961). The rarity of intrahepatic metastasis in cirrhosis of the liver. American Journal ofPathology, 39,739-746.","journal-title":"American Journal"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0140-6736(70)90870-6","article-title":"Hereditary haemorrhagic telangiectasia: aggravation by oral contraceptives?","volume":"1","author":"Rowley, P.T.; Kurnick, J.; Cheville, R.","year":"1970","unstructured":"Rowley, P. T., Kurnick, J., and Cheville, R. (1970). Hereditary haemorrhagic telangiectasia: aggravation by oral contraceptives? (Letter). Lancet, 1, 474-475.","journal-title":"(Letter). Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1002\/path.1700440105","article-title":"Familial haemorrhagic telangiectasia associated with multiple aneurysms of the splenic artery","volume":"44","author":"Schuster, N.H.","year":"1937","unstructured":"Schuster, N. H. (1937). Familial haemorrhagic telangiectasia associated with multiple aneurysms of the splenic artery. Journal of Pathology and Bacteriology, 44, 2939.","journal-title":"Journal of Pathology and Bacteriology"},{"key":"ref_20","first-page":"25","article-title":"Staining methods of Australia antigen in paraffin section","volume":"44","author":"Shikata, T.; Uzawa, T.; Yoshiwara, N.; Akatsuka, T.; Yamazaki, S.","year":"1974","unstructured":"Shikata, T., Uzawa, T., Yoshiwara, N., Akatsuka, T., and Yamazaki, S. (1974). Staining methods of Australia antigen in paraffin section. Japanese Journal of Experimental Medicine, 44, 25-36.","journal-title":"Japanese Journal of Experimental Medicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0002-9343(54)90142-4","article-title":"Hereditary hemorrhagic telangiectasia: nine cases in one Negro family, with special reference to hepatic lesions","volume":"17","author":"Smith, J.L.; Lineback, M.I.","year":"1954","unstructured":"Smith, J. L., and Lineback, M. I. (1954). Hereditary hemorrhagic telangiectasia: nine cases in one Negro family, with special reference to hepatic lesions. American Journal of Medicine, 17, 41-49.","journal-title":"American Journal of Medicine"},{"key":"ref_22","first-page":"943","article-title":"Nodular regenerative hyperplasia of the liver","volume":"35","author":"Steiner, P.E.","year":"1959","unstructured":"Steiner, P. E. (1959). Nodular regenerative hyperplasia of the liver. American Journal ofPathology, 35, 943-953.","journal-title":"American Journal ofPathology"},{"key":"ref_23","first-page":"95","article-title":"Hereditary haemorrhagic telangiectasia: A case with hepatocellular carcinoma and acquired hepatocerebral degeneration","volume":"99","author":"Sussman, E.B.; Steinberg, S.S.","year":"1975","unstructured":"Sussman, E. B., and Steinberg, S. S. (1975). Hereditary haemorrhagic telangiectasia: A case with hepatocellular carcinoma and acquired hepatocerebral degeneration. Archives ofPathology, 99, 95-100.","journal-title":"Archives ofPathology"},{"key":"ref_24","first-page":"384386","article-title":"Hereditary hemorrhagic telangiectasia: Presenting as an unusual gastric lesion","volume":"68","author":"Tedesco, F.J.; Hosty, T.A.; Sumner, H.W.","year":"1975","unstructured":"Tedesco, F. J., Hosty, T. A., and Sumner, H. W. (1975). Hereditary hemorrhagic telangiectasia: Presenting as an unusual gastric lesion. Gastroenterology, 68, 384386.","journal-title":"Gastroenterology"},{"key":"ref_25","first-page":"290","article-title":"Hemangiomatose familiale de Rendu-Osler et cirrhose hepatique (contribution a l'etude des cirrhoses familiales)","volume":"38","author":"Van Bogaert, L.; Scherer, H.J.","year":"1935","unstructured":"Van Bogaert, L., and Scherer, H. J. (1935). Hemangiomatose familiale de Rendu-Osler et cirrhose hepatique (contribution a l'etude des cirrhoses familiales). Annales de Medecine, 38, 290-300.","journal-title":"Annales de Medecine"},{"key":"ref_26","first-page":"214","article-title":"Oslersche Krankheit und Leberveranderung (Zugleich ein Beitrag zur cerebralen Form der Teleangiectasia haemorrhagica hereditaria)","volume-title":"Deutsches","volume":"189","author":"Werner, M.","year":"1942","unstructured":"Werner, M. (1942). Oslersche Krankheit und Leberveranderung (Zugleich ein Beitrag zur cerebralen Form der Teleangiectasia haemorrhagica hereditaria). Deutsches Archiv fur klinische Medizin, 189, 214-224."},{"key":"ref_27","first-page":"730","article-title":"Teleangiectasia haemorrhagica hereditaria and liver cirrhosis","volume":"38","author":"Ytrehus, 0","year":"1948","unstructured":"Ytrehus, 0. (1948). Teleangiectasia haemorrhagica hereditaria and liver cirrhosis. (Norwegian). Nordisk Medicin, 38, 730-733.","journal-title":"(Norwegian). Nordisk Medicin"},{"key":"ref_28","first-page":"66","article-title":"Liver fibrosis in hereditary hemorrhagic telangiectasia","volume":"74","author":"Zelman, S.","year":"1962","unstructured":"Zelman, S. (1962). Liver fibrosis in hereditary hemorrhagic telangiectasia. Archives ofPathology, 74, 66-72.","journal-title":"Archives ofPathology"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.30.12.1134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T16:01:05Z","timestamp":1717171265000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.30.12.1134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,12]]},"references-count":28,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1977,12,1]]},"published-print":{"date-parts":[[1977,12]]}},"alternative-id":["10.1136\/jcp.30.12.1134"],"URL":"https:\/\/doi.org\/10.1136\/jcp.30.12.1134","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,12]]}}}