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Although histological appearances and volume percentage measurement of component tissues suggested that the glandular epithelium had involuted after iodine treatment, measurement of their absolute mass indicated that the mean mass of epithelium was the same in both groups and that involution had not occurred. We conclude that considerable confusion in the thyroid literature has arisen through incorrect use of the term involution.<\/jats:p>","DOI":"10.1136\/jcp.30.2.99","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"99-102","source":"Crossref","is-referenced-by-count":6,"title":["Does preoperative iodide treatment for thyrotoxicosis bring about involution?"],"prefix":"10.1136","volume":"30","author":[{"given":"T J","family":"Wilkin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Michie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,2,1]]},"reference":[{"key":"ref_1","article-title":"of McNalty's British Medical Dictionary","author":"Dictionary, Butterworth's Medical","year":"1965","unstructured":"Butterworth's Medical Dictionary (1965). 2nd edition of McNalty's British Medical Dictionary. 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Acta Endrocrinologica, 61, 393-399.","journal-title":"Acta Endrocrinologica"},{"key":"ref_5","first-page":"635","article-title":"A histochemical comparison of primary thyroid hyperplasia and adenomatous goiter","volume":"59","author":"Haley, H.L.; Dews, G.M.; Sommers, S.C.","year":"1955","unstructured":"Haley, H. L., Dews, G. M., and Sommers, S. C. (1955). A histochemical comparison of primary thyroid hyperplasia and adenomatous goiter. Archives ofPathology, 59, 635-640.","journal-title":"Archives ofPathology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/bjs.1800590715","article-title":"The effect of remnant size on the outcome of subtotal thyroidectomy for thyrotoxicosis","volume":"59","author":"Hedley, A.J.; Michie, W.; Duncan, T.; Hems, G.; Crooks, J.","year":"1972","unstructured":"Hedley, A. J., Michie, W., Duncan, T., Hems, G., and Crooks, J. (1972). The effect of remnant size on the outcome of subtotal thyroidectomy for thyrotoxicosis. 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In The Thyroid, edited by S. C. Werner and S. H. Ingbar, 3rd edition, p. 349. Harper and Row, New York.","edition":"3rd edition"},{"key":"ref_10","first-page":"713","article-title":"Relation of thyroid-stimulating immunoglobulins to thyroid function and effects of surgery, radioiodine, and antithyroid drugs","volume":"1","author":"Mukhtar, E.D.; Smith, B.R.; Pyle, G.A.; Hall, R.; Vice, P.","year":"1975","unstructured":"Mukhtar, E. D., Smith, B. R., Pyle, G. A., Hall, R., and Vice, P. (1975). Relation of thyroid-stimulating immunoglobulins to thyroid function and effects of surgery, radioiodine, and antithyroid drugs. Lancet, 1, 713-715.","journal-title":"Lancet"},{"key":"ref_11","first-page":"27","article-title":"What has thiouracil taught us about the pathologic physiology of Graves'","volume":"55","author":"Rawson, R.W.; McArthur, J.W.","year":"1947","unstructured":"Rawson, R. W. and McArthur, J. W. (1947). What has thiouracil taught us about the pathologic physiology of Graves' disease? Western Journal of Surgery, 55, 27-38.","journal-title":"disease? Western Journal of Surgery"},{"key":"ref_12","first-page":"285","article-title":"The histological changes brought about in cases of exophthalmic goitre by the administration of iodine","volume":"37","author":"Rienhoff, Jr, W.F.","year":"1925","unstructured":"Rienhoff, W. F., Jr. (1925). The histological changes brought about in cases of exophthalmic goitre by the administration of iodine. Bulletin of the Johns Hopkins Hospital, 37, 285-306.","journal-title":"Bulletin of the Johns Hopkins Hospital"},{"key":"ref_13","first-page":"147","author":"Sommers, S.C.","year":"1968","unstructured":"Sommers, S. C. (1968). In Endocrine Pathology, edited by J. M. B. Bloodworth, Jr., p. 147. Williams and Wilkins, Baltimore."},{"key":"ref_14","article-title":"Die Struma basedowiana. In Druisen mit innerer Sekretion (Handbuch der speziellen pathologischen Anatomie und","volume-title":"Henke and 0","author":"Wegelin, C.","year":"1926","unstructured":"Wegelin, C. (1926). Die Struma basedowiana. In Druisen mit innerer Sekretion (Handbuch der speziellen pathologischen Anatomie und Histologie, edited by F. Henke and 0."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/jcp.28.2.94","article-title":"The predictive value of histometry of thyroid tissue in anticipating hypothyroidism after subtotal thyroidectomy for primary thyrotoxicosis","volume":"28","author":"Young, R.J.; Beck, J.S.; Michie, W.","year":"1975","unstructured":"Young, R. J., Beck, J. S., and Michie, W. (1975). The predictive value of histometry of thyroid tissue in anticipating hypothyroidism after subtotal thyroidectomy for primary thyrotoxicosis. 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