{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:17:37Z","timestamp":1765595857963,"version":"3.48.0"},"reference-count":20,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1977,4]]},"abstract":"<jats:p>As an index of delayed hypersensitivity in vitro halothane macrophage migration inhibition factor tests (halothane-MIF tests) were performed on peripheral blood lymphocytes from five patients with halothane hepatitis. Twenty-two subjects exposed to halothane, but with no evidence of jaundice, five 'healthy' hospital anaesthetists, nine jaundiced subjects without halothane exposure, and 10 healthy subjects with no history of exposure to halothane were also tested. The halothane-MIF test was positive in four of the five patients with halothane-induced hepatitis; the negative result was in a patient on steroid treatment. The test was negative in all other subjects. Our findings suggest that the halothane-MIF test may be of value in the diagnosis of halothane-induced hepatitis and as a screeening procedure for the identification of susceptible subjects.<\/jats:p>","DOI":"10.1136\/jcp.30.4.312","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"312-316","source":"Crossref","is-referenced-by-count":13,"title":["Halothane macrophage migration inhibtiion factor test in halothane-associated hepatitis."],"prefix":"10.1136","volume":"30","author":[{"given":"C D","family":"Price","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A R","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W J","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,4,1]]},"reference":[{"key":"ref_1","volume-title":"The assay of inhibition of macrophage migration and the production of migration inhibitory factor (MIF) and skin reactive factor (SRF) in the guinea pig. In In Vitro Methods in Cell Mediated Immunity","author":"Bloom, B.R.; Bennett, B.","year":"1971","unstructured":"Bloom, B. R. and Bennett, B. (1971). The assay of inhibition of macrophage migration and the production of migration inhibitory factor (MIF) and skin reactive factor (SRF) in the guinea pig. In In Vitro Methods in Cell Mediated Immunity, edited by B. R. Bloom and P."},{"key":"ref_2","first-page":"235","author":"Glade, R.","year":"1958","unstructured":"R. Glade, pp. 235-248. Academic Press, New York. Bumap, T. K., Galla, S. J., and Vandam, L. D. (1958)."},{"key":"ref_3","first-page":"135","article-title":"Halothanehepatitis-A critical review","volume":"51","author":"Camey, F.M.T.; Van Dyke, R.A.","year":"1972","unstructured":"Camey, F. M. T. and Van Dyke, R. A. (1972). Halothanehepatitis-A critical review. Anesth. Analg. Curr. Res., 51, 135-160.","journal-title":"Anesth. Analg. Curr. Res"},{"key":"ref_4","article-title":"Recurrent hepatitis in patients receiving multiple halothane anesthetics for radium treatment of carcinoma of the cervix uteri","author":"Hughes, M.; Powell, L.W.","year":"1970","unstructured":"Hughes, M. and Powell, L. W. (1970). Recurrent hepatitis in patients receiving multiple halothane anesthetics for radium treatment of carcinoma of the cervix uteri."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/bmj.1.5896.5","article-title":"Jaundice after repeated exposure to halothane: an analysis of reports to the committee on safety of medicines","volume":"1","author":"Inman, W.H.W.; Mushin, W.W.","year":"1974","unstructured":"Inman, W. H. W. and Mushin, W. W. (1974). Jaundice after repeated exposure to halothane: an analysis of reports to the committee on safety of medicines. Brit. Med. J., 1, 5-10.","journal-title":"Brit. Med. J"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/bmj.4.5831.47-b","article-title":"Test in halothane jaundice (Letter)","volume":"4","author":"Jones Williams, W.; Pioli, E.; Horton, J.N.; Waldron, A.","year":"1972","unstructured":"Jones Williams, W., Pioli, E., Horton, J. N., and Waldron, A. (1972a). M.I.F. Test in halothane jaundice (Letter). Brit. med. J., 4, 47.","journal-title":"Brit. med. J"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/jcp.25.11.951","article-title":"The Kmif (Kveim-induced macrophage migration inhibition factor) test in sarcoidosis","volume":"25","author":"Jones Williams, W.; Pioli, E.; Jones, D.J.; Dighero, M.","year":"1972","unstructured":"Jones Williams, W., Pioli, E., Jones, D. J., and Dighero, M. (1972b). The Kmif (Kveim-induced macrophage migration inhibition factor) test in sarcoidosis. J. clin. Path., 25, 951-954.","journal-title":"J. clin. Path"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1056\/NEJM196903062801001","article-title":"Recurrent hepatitis attributable to halothane sensitization in an anesthetist","volume":"280","author":"Klatskin, G.; Kimberg, D.V.","year":"1969","unstructured":"Klatskin, G. and Kimberg, D. V. (1969). Recurrent hepatitis attributable to halothane sensitization in an anesthetist. New. Engl. J. Med., 280, 515-522.","journal-title":"New. Engl. J. Med"},{"key":"ref_9","first-page":"71","article-title":"Hepatitis after exposure to halothane","author":"Klion, F.M.; Schaffner, F.; Pooper, H.","year":"1969","unstructured":"Klion, F. M., Schaffner, F., and Pooper, H. (1969). Hepatitis after exposure to halothane. Ann. intern. Med., 71,467-477.","journal-title":"Ann. intern. Med"},{"key":"ref_10","first-page":"99","article-title":"Halothanerelated hepatitis","volume":"44","author":"Moult, P.J.A.; Sherlock, S.","year":"1975","unstructured":"Moult, P. J. A. and Sherlock, S. (1975). Halothanerelated hepatitis. Quart. J. Med., 44, 99-114.","journal-title":"Quart. J. Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/bmj.3.5765.18","article-title":"Posthalothane jaundice in relation to previous administration of halothane","volume":"3","author":"Mushin, W.W.; Rosen, M.; Jones, E.V.","year":"1971","unstructured":"Mushin, W. W., Rosen, M., and Jones, E. V. (1971). Posthalothane jaundice in relation to previous administration of halothane. Brit. med. J., 3, 18-22.","journal-title":"Brit. med. J"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1056\/NEJM197008062830602","article-title":"Lymphocyte stimulation induced by halothane in patients with hepatitis following exposure to halothane","volume":"283","author":"Paronetto, F.; Popper, H.","year":"1970","unstructured":"Paronetto, F. and Popper, H. (1970). Lymphocyte stimulation induced by halothane in patients with hepatitis following exposure to halothane. New Engl. J. Med., 283, 277-280.","journal-title":"New Engl. J. Med"},{"key":"ref_13","first-page":"47","article-title":"Hepatic necrosis associated with halothane anesthesia","author":"Peters, R.L.; Edmondson, H.A.; Reynolds, T.B.; Meister, J.C.; Curphey, T.J.","year":"1969","unstructured":"Peters, R. L., Edmondson, H. A., Reynolds, T. B., Meister, J. C., and Curphey, T. J. (1969). Hepatic necrosis associated with halothane anesthesia. Amer. J. Med., 47,748-764.","journal-title":"Amer. J. Med"},{"key":"ref_14","first-page":"\"24","article-title":"Role of in vitro and in vivo tests of hypersensitivity in beryllium workers","volume":"30","author":"Price, C.D.; Williams, W.J.; Pugh, A.; Joynson, D.H.","year":"1977","unstructured":"Price, C. D., Williams, W. J., Pugh, A., and Joynson, D. H. (1977). Role of in vitro and in vivo tests of hypersensitivity in beryllium workers. J. clin. Path., 30, 24-28. Sharpstone. P., Medley, D. R. K., and Williams, R. (1971). Halothane hepatitis-a preventable disease? Brit. med. J., 1, 448-450.","journal-title":"J. clin. Path; Halothane hepatitis-a preventable disease"},{"key":"ref_15","article-title":"Postoperative hepatic necrosis","author":"Slater, E.M.; Gibson, J.M.; Dykes, M.H.M.; Walzer, S.G.","year":"1964","unstructured":"Slater, E. M., Gibson, J. M., Dykes, M. H. M., and Walzer, S. G. (1964). Postoperative hepatic necrosis."},{"year":"1975","author":"Trowell, J.; Peto, R.; Crampton Smith, A.","key":"ref_16","unstructured":"Trowell, J., Peto, R., and Crampton Smith, A. (1975)."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/00000542-195807000-00018","article-title":"Post-operative death after Fluothane","volume":"19","author":"Virtue, R.; Payne, K.W.","year":"1958","unstructured":"Virtue, R. and Payne, K. W. (1958). Post-operative death after Fluothane. Anesthesiology, 19, 562-563.","journal-title":"Anesthesiology"},{"key":"ref_18","article-title":"Lymphocyte transformation: absence of increased responses in alleged halothane jaundice","author":"Walton, B.; Dumonde, D.C.; Williams, C.; Jones, D.; Strunin, J.M.; Layton, J.M.; Strunin, L.; Simpson, R.","year":"1973","unstructured":"Walton, B., Dumonde, D. C., Williams, C., Jones, D., Strunin, J. M., Layton, J. M., Strunin, L., and Simpson, R. (1973). Lymphocyte transformation: absence of increased responses in alleged halothane jaundice. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1136\/bmj.1.6019.1171","article-title":"Unexplained hepatitis following halothane","volume":"1","author":"Walton, B.; Simpson, B.R.; Strunin, L.; Donach, D.; Perrin, J.; Appleyard, A.J.","year":"1976","unstructured":"Walton, B., Simpson, B. R., Strunin, L., Donach, D., Perrin, J., and Appleyard, A. J. (1976). Unexplained hepatitis following halothane. Brit. med. J., 1, 1171-1176.","journal-title":"Brit. med. J"},{"article-title":"Controlled prospective study of the effect on liver function of multiple exposures to halothane","year":"1975","key":"ref_20","unstructured":"Wright, R., Eade, 0. E., Chisholm, M., Hawksley, M., Lloyd, B., Moles, T. M., Edwards, J. C., and Gardner, M. J. (1975). Controlled prospective study of the effect on liver function of multiple exposures to halothane."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.30.4.312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:12:40Z","timestamp":1765595560000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.30.4.312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,4]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1977,4,1]]},"published-print":{"date-parts":[[1977,4]]}},"alternative-id":["10.1136\/jcp.30.4.312"],"URL":"https:\/\/doi.org\/10.1136\/jcp.30.4.312","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1977,4]]}}}