{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:26:37Z","timestamp":1782789997045,"version":"3.54.5"},"reference-count":21,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:p>The results of histological and immunohistochemical examination of gastric and duodenal biopsy specimens from 50 volunteers without a clinical history of gastrointestinal disease are reported. Multiple specimens of tissue from standard sites in the stomach and duodenum were carefully orientated, and serially sectioned for examination by light microscopy and for immunohistochemical characterisation of plasma cells within the lamina propria. The antrum and fundus were normal in 32 of the 50 subjects but the other 18 showed histopathological evidence of gastritis in either the antrum or fundus. The latter appeared to be age-related. There was considerable variation in the appearance of the surface epithelium of the duodenum within as well as among individual subjects. Superficial gastric metaplasia in one or more biopsy specimens from the duodenal bulb was found in 64% of individuals. Histopathological examination of the duodenum revealed signs of chronic inflammation in 12% of the subjects. In two individuals there was active inflammation but in only one of these was the diagnosis made on endoscopic appearances. Histological criteria important for the diagnosis of duodenitis are discussed. The number of plasma cells in different biopsy specimens from subjects not showing histological signs of inflammation was variable. The ratio IgA:IgG:IgM producing plasma cells was remarkably constant from subject to subject as well as from specimen to specimen.<\/jats:p>","DOI":"10.1136\/jcp.31.1.69","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"69-77","source":"Crossref","is-referenced-by-count":145,"title":["Gastric and duodenal mucosa in 'healthy' individuals. An endoscopic and histopathological study of 50 volunteers."],"prefix":"10.1136","volume":"31","author":[{"given":"J","family":"Kreuning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F T","family":"Bosman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Kuiper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Wal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lindeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1978,1,1]]},"reference":[{"key":"ref_1","first-page":"11751179","article-title":"Peroxydase labelled antibody and Fab conjugates with enhanced intracellular penetration","volume":"8","author":"Avrameas, S.; Ternynck, T.","year":"1971","unstructured":"Avrameas, S., and Ternynck, T. (1971). Peroxydase labelled antibody and Fab conjugates with enhanced intracellular penetration. Immunochemistry, 8, 11751179.","journal-title":"Immunochemistry"},{"key":"ref_2","first-page":"376","article-title":"Chronic duodenitis","volume":"6","author":"Beck, I.T.; Kahn, D.S.; Lacerte, M.; Solymar, J.; Callegarini, U.; Geokas, M.C.; Phelps, E.","year":"1965","unstructured":"Beck, I. T., Kahn, D. S., Lacerte, M., Solymar, J., Callegarini, U., Geokas, M. C., and Phelps, E. (1965). 'Chronic duodenitis': a clinical pathological entity? Gut, 6, 376-383.","journal-title":"a clinical pathological entity? Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF00511210","article-title":"The influence of fixation on immunoreactivity of plasma cells in routinely processed intestinal biopsy specimens","volume":"53","author":"Bosman, F.T.; Lindeman, J.; Kuiper, G.; der Wal A. M., Van; Kreuning, J.","year":"1977","unstructured":"Bosman, F. T., Lindeman, J., Kuiper, G., Van der Wal A. M., and Kreuning, J. (1977). The influence of fixation on immunoreactivity of plasma cells in routinely processed intestinal biopsy specimens. Histochemistry, 53, 57-62.","journal-title":"Histochemistry"},{"key":"ref_4","first-page":"611","article-title":"Les duodenites non specifiques","volume":"63","author":"Chaput, J.C.; Petite, J.P.; Rain, B.; Buffet, C.; Camillieri, J.P.; Eitenne, J.P.","year":"1974","unstructured":"Chaput, J. C., Petite, J. P., Rain, B., Buffet, C., Camillieri, J. P., and Eitenne, J. P. (1974). Les duodenites non specifiques. Archives FranVaises des Maladies de l'Appareil D.gestif, 63, 611-623.","journal-title":"Archives FranVaises des Maladies de l'Appareil D.gestif"},{"key":"ref_5","article-title":"Duodenitis","author":"Cheli, R.; Aste, H.","year":"1976","unstructured":"Cheli, R., and Aste, H. (1976). Duodenitis. GeorgThieme, Stuttgart."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/14.4.291","article-title":"The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique","volume":"14","author":"Graham, R.C.; Karnovsky, M.J.","year":"1966","unstructured":"Graham, R. C., and Karnovsky, M. J. (1966). The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. Journal of Histochemistry and Cytochemistry, 14, 291-302.","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"ref_7","first-page":"457","article-title":"An immunofluorescence procedure for the detection of intracellular immunoglobulins","volume":"4","author":"Hijmans, W.; Schuit, H.R.E.; Klein, F.","year":"1969","unstructured":"Hijmans, W., Schuit, H. R. E., and Klein, F. (1969). An immunofluorescence procedure for the detection of intracellular immunoglobulins. Clinical and Experimental Immunology, 4, 457-472.","journal-title":"Clinical and Experimental Immunology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000197027","article-title":"Heterotopic gastric mucosa in the duodenum","volume":"3","author":"Hoedemaeker, Ph J.","year":"1970","unstructured":"Hoedemaeker, Ph. J. (1970). Heterotopic gastric mucosa in the duodenum. Digestion, 3, 165-173.","journal-title":"Digestion"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0016-5107(74)73790-7","article-title":"Endoscopic biopsies of normal duodenal mucosa","volume":"21","author":"Korn, E.R.; Foroozan, P.","year":"1974","unstructured":"Korn, E. R. and Foroozan, P. (1974). Endoscopic biopsies of normal duodenal mucosa. Gastrointestinal Endoscopy, 21, 51-54.","journal-title":"Gastrointestinal Endoscopy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1136\/gut.17.9.719","article-title":"Gastritis duodenitis, and circulating levels of gastrin in duodenal ulcer before and after vagotomy","volume":"17","author":"Meikle, D.D.; Taylor, K.B.; Truelove, S.C.; Whitehead, R.","year":"1976","unstructured":"Meikle, D. D., Taylor, K. B., Truelove, S. C., and Whitehead, R. (1976). Gastritis duodenitis, and circulating levels of gastrin in duodenal ulcer before and after vagotomy. Gut, 17, 719-728.","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0046-8177(75)80176-6","article-title":"Small intestinal biopsy","volume":"6","author":"Perera, D.R.; Weinstein, W.M.; Rubin, C.E.","year":"1975","unstructured":"Perera, D. R., Weinstein, W. M., and Rubin, C. E. (1975). Small intestinal biopsy. 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BUTTOLPH"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.31.1.69","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:57:41Z","timestamp":1765076261000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.31.1.69"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1978,1,1]]},"published-print":{"date-parts":[[1978,1]]}},"alternative-id":["10.1136\/jcp.31.1.69"],"URL":"https:\/\/doi.org\/10.1136\/jcp.31.1.69","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,1]]}}}