{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:28:25Z","timestamp":1765600105771,"version":"3.48.0"},"reference-count":11,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1978,10]]},"abstract":"<jats:p>Haemoglobin A2 levels were measured in 50 patients with vitamin B12 deficiency, 50 patients with folate deficiency, and six patients with combined deficiencies of these vitamins. All were normal except for three patients with vitamin B12 deficiency, who had a slightly elevated Hb A2 level; this fell to normal after vitamin B12 therapy. It is concluded that haemoglobin A2 levels are usually normal in vitamin B12 or folate deficiency. However, raised levels of haemoglobin A2 may be found, but these are not as high as is found in beta thalassaemia trait and should not cause difficutly in diagnosis.<\/jats:p>","DOI":"10.1136\/jcp.31.10.960","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"960-962","source":"Crossref","is-referenced-by-count":4,"title":["Haemoglobin A2 levels in vitamin B12 and folate deficiency."],"prefix":"10.1136","volume":"31","author":[{"given":"L A","family":"Henshaw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Tizzard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Booth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Beard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/ajcp\/67.3.219","article-title":"Haemoglobin A2 levels in health and various haematologic disorders","volume":"67","author":"Alperin, J.B.; Dow, P.A.; Petteway, M.B.","year":"1977","unstructured":"Alperin, J. 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Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. Journal of Clinical Pathology, 19, 17-28.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_4","first-page":"296","article-title":"Studies on the heterogeneity of haemoglobin VII minor haemoglobin components in haematological diseases","volume":"11","author":"Horton, B.F.; Huisman, T.H.J.","year":"1965","unstructured":"Horton, B. F., and Huisman, T. H. J. (1965). Studies on the heterogeneity of haemoglobin VII minor haemoglobin components in haematological diseases. British Journal of Haematology, 11, 296-304.","journal-title":"British Journal of Haematology"},{"key":"ref_5","article-title":"Starch block electrophoretic studies of human haemoglobin solutions","author":"Josephson, A.M.; Masri, M.S.; Singer, L.; Dworkin, D.; Singer, K.","year":"1958","unstructured":"Josephson, A. M., Masri, M. S., Singer, L., Dworkin, D., and Singer, K. (1958). Starch block electrophoretic studies of human haemoglobin solutions."},{"key":"ref_6","first-page":"\"543","article-title":"Results in cord blood, thalassemia and other haematologic disorders: comparison with Tiselius electrophoresis","volume":"13","author":"Lau, K.S.; Gottlieb, C.; Wasserman, L.R.; Herbert, V.","year":"1965","unstructured":"Results in cord blood, thalassemia and other haematologic disorders: comparison with Tiselius electrophoresis. Blood, 13, 543-551. Lau, K. S., Gottlieb, C., Wasserman, L. R., and Herbert, V. (1965). Measurement of serum vitamin B12 level using radioisotopic dilution and coated charcoal. Blood, 26, 202-214.","journal-title":"Blood; Measurement of serum vitamin B12 level using radioisotopic dilution and coated charcoal"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1136\/jcp.18.6.790","article-title":"Rapid electrophoresis and quantitation of haemoglobins on cellulose acetate","volume":"18","author":"Marengo-Rowe, A.J.","year":"1965","unstructured":"Marengo-Rowe, A. J. (1965). Rapid electrophoresis and quantitation of haemoglobins on cellulose acetate. Journal of Clinical Pathology, 18, 790-792.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_8","first-page":"4","article-title":"Haemoglobin Zurich: clinical, chemical and kinetic studies","volume":"39","author":"Rieder, R.F.; Zinkham, W.H.; Holtzman, N.A.","year":"1965","unstructured":"Rieder, R. F., Zinkham, W. H., and Holtzman, N. A. (1965). Haemoglobin Zurich: clinical, chemical and kinetic studies. American Journal of Medicine, 39, 4-20.","journal-title":"American Journal of Medicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1056\/NEJM197102182840703","article-title":"Hemoglobin components in patients with diabetes mellitus","volume":"284","author":"Trivelli, L.A.; Ranney, H.M.; Lai, H.T.","year":"1971","unstructured":"Trivelli, L. A., Ranney, H. M., and Lai, H. T. (1971). Hemoglobin components in patients with diabetes mellitus. New England Journal of Medicine, 284, 353-357.","journal-title":"New England Journal of Medicine"},{"key":"ref_10","first-page":"85","article-title":"The effect of iron deficiency on the levels of haemoglobins A2 and E","volume":"71","author":"Wasi, P.; Disthasongchan, P.; Na-Nakorn, S.","year":"1968","unstructured":"Wasi, P., Disthasongchan, P., and Na-Nakorn, S. (1968). The effect of iron deficiency on the levels of haemoglobins A2 and E. Journal of Laboratory and Clinical Medicine, 71, 85-91.","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1136\/jcp.14.4.335","article-title":"Studies on the folic acid activity of human serum","volume":"14","author":"Waters, A.H.; Mollin, D.L.","year":"1961","unstructured":"Waters, A. H., and Mollin, D. L. (1961). Studies on the folic acid activity of human serum. 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