{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:13:52Z","timestamp":1765599232449,"version":"3.48.0"},"reference-count":23,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1978,11]]},"abstract":"<jats:p>Factor IX concentrates have been widely advocated in the treatment of haemophilic patients with factor VIII inhibitors. Five such patients were given the 'activated' factor IX concentrate--factor VIII inhibitor bypassing activity (Feiba)--for 14 separate bleeding episodes. In six of the episodes, including two with external blood loss, bleeding progressed in spite of treatment. In none of the other eight episodes was there a prompt response, and it was not possible to ascribe a definite therapeutic effect.<\/jats:p>","DOI":"10.1136\/jcp.31.11.1102","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1102-1105","source":"Crossref","is-referenced-by-count":21,"title":["Failure of factor VIII inhibitor bypassing activity (Feiba) to secure haemostasis in haemophilic patients with antibodies."],"prefix":"10.1136","volume":"31","author":[{"given":"D H","family":"Parry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A L","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0022-3476(76)80982-1","article-title":"Prothrombin complex concentrates (Konyne) in the treatment of hemophilic patients with factor VIII inhibitors","volume":"88","author":"Abildgaard, C.F.; Britton, M.; Harrison, J.","year":"1976","unstructured":"Abildgaard, C. F., Britton, M., and Harrison, J. (1976). Prothrombin complex concentrates (Konyne) in the treatment of hemophilic patients with factor VIII inhibitors. Journal of Pediatrics, 88, 200-205.","journal-title":"Journal of Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0140-6736(75)92683-5","article-title":"Prothrombincomplex concentrate in treatment of classical haemophilia with factor-VIII antibody (Letter)","volume":"2","author":"Allain, J.P.; Krieger, G.R.","year":"1975","unstructured":"Allain, J. P., and Krieger, G. R. (1975). Prothrombincomplex concentrate in treatment of classical haemophilia with factor-VIII antibody (Letter). Lancet, 2, 1203.","journal-title":"Lancet"},{"key":"ref_3","article-title":"Human Blood Coagulation, Haemostasis and Thrombosis","author":"Biggs, R.","year":"1976","unstructured":"Biggs, R. (1976). Human Blood Coagulation, Haemostasis and Thrombosis, 2nd edition. Blackwell, Oxford.","edition":"2nd edition"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2141.1959.tb04049.x","article-title":"A method for the study of antihaemophilic globulin inhibitors with reference to six cases","volume":"5","author":"Biggs, R.; Bidwell, E.","year":"1959","unstructured":"Biggs, R., and Bidwell, E. (1959). A method for the study of antihaemophilic globulin inhibitors with reference to six cases. British Journal of Haematology, 5, 379-395.","journal-title":"British Journal of Haematology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1055\/s-0038-1651858","article-title":"Treatment of anti-factor VIII antibodies","volume":"38","author":"Blatt, P.M.; White, II, G.C.; McMillan, C.W.; Roberts, H.R.","year":"1977","unstructured":"Blatt, P. M., White, G. C., II, McMillan, C. W., and Roberts, H. R. (1977). Treatment of anti-factor VIII antibodies. 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Lancet, 2, 933.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1182\/blood.V41.1.113.113","article-title":"Successful management of a subdural hematoma in a hemophiliac with an anti-factor VIII antibody","volume":"41","author":"Edson, J.R.; McArthur, J.R.; Branda, R.F.; McCullough, J.J.; Chou, S.N.","year":"1973","unstructured":"Edson, J. R., McArthur, J. R., Branda, R. F., McCullough, J. J., and Chou, S. N. (1973). Successful management of a subdural hematoma in a hemophiliac with an anti-factor VIII antibody. Blood, 41, 113-122.","journal-title":"Blood"},{"key":"ref_9","first-page":"101","article-title":"Preparations with factor VIII inhibitor bypassing activity. Workshop on Inhibitors ofFactors VIII and IX","author":"Elsinger, F.","year":"1977","unstructured":"Elsinger, F. (1977). Preparations with factor VIII inhibitor bypassing activity. Workshop on Inhibitors ofFactors VIII and IX, p. 101. Facultas-Verlag, Vienna."},{"key":"ref_10","article-title":"'Auto'-factor IX concentrate: a new therapeutic approach to treatment of hemophilia A patients with inhibitors","volume":"295","author":"Fekete, L.F.; Holst, S.L.; Peetom, F.; Deveber, L.L.","year":"1972","unstructured":"Fekete, L. F., Holst, S. L., Peetom, F., and Deveber, L. L. (1972). 'Auto'-factor IX concentrate: a new therapeutic approach to treatment of hemophilia A patients with inhibitors. 14th International Congress of Hematology, Sao Paulo, Brazil, Abstracts, No. 295."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1001\/jama.1976.03270190017020","article-title":"Antihemophilic factor inhibitors: management with prothrombin complex concentrates","volume":"236","author":"Kelly, P.; Penner, J.A.","year":"1976","unstructured":"Kelly, P., and Penner, J. A. (1976). Antihemophilic factor inhibitors: management with prothrombin complex concentrates. 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Thrombosis Research 11, 643-651.","journal-title":"Thrombosis Research"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-0028-1104885","article-title":"Notfallbehandlung von Blutungskomplikationen bei HemmkorperHamophilie mit aktivierten Prothrombinkomplexkonzentraten","volume":"102","author":"Rasche, H.; Bindewald, H.; Kohle, W.; Scheck, R.; Heinrich, R.; Seibert, K.","year":"1977","unstructured":"Rasche, H., Bindewald, H., Kohle, W., Scheck, R., Heinrich, R., and Seibert, K. (1977). Notfallbehandlung von Blutungskomplikationen bei HemmkorperHamophilie mit aktivierten Prothrombinkomplexkonzentraten. 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