{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:44:00Z","timestamp":1760982240373,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1978,6]]},"abstract":"<jats:p>Differential cell counts were made on nine lymph nodes whose structure was replaced by diffuse Hodgkin's disease; two of these nodes had the classical histological appearance of the lymphocytic predominance subtype, four of the mixed cellularity subtype, and three of the lymphocytic depletion subtype. Our attempts to achieve valid sampling methods are recorded. The counts, in general, confirm the postulated histological basis of the Rye classification of the subtypes of the diffuse disease. The major discrepancy is that, contrary to the histological descriptions, our direct counts have shown that lymphocytes, are, in general, more numerous in the lymphocytic depletion than in the mixed cellularity subtypes. The cell counts also show that normal mononuclear cells (mainly fibroblasts and macrophage-type cells) are much more numerous in the mixed cellularity subtype than in the other forms of diffuse Hodgkin's disease; this feature has not been emphasised in the Rye classification. On the basis of our differential counts, a hypothesis is proposed that could explain the natural history of the different subtypes of diffuse Hodgkin's disease as the resultant of three processes: (a) tumour aggressiveness, (b) specific cell-mediated immunological reactions, and (c) non-immunological stromal responses.<\/jats:p>","DOI":"10.1136\/jcp.31.6.551","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"551-559","source":"Crossref","is-referenced-by-count":13,"title":["Cytological basis of histological typing of diffuse Hodgkin's disease. Demonstration of an implied misnomer in the terminology of the Rye classification."],"prefix":"10.1136","volume":"31","author":[{"given":"A E","family":"Livesey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F I","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J B","family":"Macgillivray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Slidders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,6,1]]},"reference":[{"key":"ref_1","first-page":"731","article-title":"Observer disagreement in the classification and histology of Hodgkin's disease","volume":"45","author":"Coppleson, L.W.; Factor, R.M.; Strum, S.B.; Graff, P.W.; Rappaport, H.","year":"1970","unstructured":"Coppleson, L. W., Factor, R. M., Strum, S. B., Graff, P. W., and Rappaport, H. (1970). Observer disagreement in the classification and histology of Hodgkin's disease. Journal of the National Cancer Institute, 45, 731-740.","journal-title":"Journal of the National Cancer Institute"},{"key":"ref_2","first-page":"379","article-title":"Analysis of the Rye classification of Hodgkin's disease. The prognostic significance of cellular composition","volume":"51","author":"Coppleson, L.W.; Rappaport, H.; Strum, S.B.; Rose, J.","year":"1973","unstructured":"Coppleson, L. W., Rappaport, H., Strum, S. B., and Rose, J. (1973). Analysis of the Rye classification of Hodgkin's disease. The prognostic significance of cellular composition. Journal of the National Cancer Institute, 51, 379-390.","journal-title":"Journal of the National Cancer Institute"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/jnci\/50.6.1429","article-title":"International comparability and reproducibility in histological subclassification of Hodgkin's disease","volume":"50","year":"1973","unstructured":"Correa, P., O'Conor, G. T. 0., Berard, C. W., Axtell, L. M., and Myers, M. H. (1973). International comparability and reproducibility in histological subclassification of Hodgkin's disease. Journal of the National Cancer Institute, 50, 1429-1435.","journal-title":"Journal of the National Cancer Institute"},{"key":"ref_4","first-page":"1755","article-title":"Criteria for involvement of lymph nodes, bone marrow, spleen and liver in Hodgkin's disease","volume":"31","author":"Lukes, R.J.","year":"1971","unstructured":"Lukes, R. J. (1971). Criteria for involvement of lymph nodes, bone marrow, spleen and liver in Hodgkin's disease. Cancer Research, 31, 1755-1767.","journal-title":"Cancer Research"},{"key":"ref_5","first-page":"1063","article-title":"The pathology and nomenclature of Hodgkin's disease","volume":"26","author":"Lukes, R.J.; Butler, J.J.","year":"1966","unstructured":"Lukes, R. J., and Butler, J. J. (1966). The pathology and nomenclature of Hodgkin's disease. Cancer Research, 26, 1063-1081.","journal-title":"Cancer Research"},{"key":"ref_6","first-page":"1311","article-title":"Report of the nomenclature committee","volume":"26","author":"Lukes, R.J.; Craver, L.F.; Hall, T.C.; Rappaport, H.; Rubin, P.","year":"1966","unstructured":"Lukes, R. J., Craver, L. F., Hall, T. C., Rappaport, H., and Rubin, P. (1966). Report of the nomenclature committee. Cancer Research, 26, 1311.","journal-title":"Cancer Research"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1136\/jcp.27.8.615","article-title":"Measurement of section thickness in quantitative microscopy with special reference to enzyme histochemistry","volume":"27","author":"Pearse, A.D.; Marks, R.","year":"1974","unstructured":"Pearse, A. D., and Marks, R. (1974). Measurement of section thickness in quantitative microscopy with special reference to enzyme histochemistry. Journal of Clinical Pathology, 27, 615-618.","journal-title":"Journal of Clinical Pathology"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.31.6.551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:12:41Z","timestamp":1758805961000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.31.6.551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,6]]},"references-count":7,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1978,6,1]]},"published-print":{"date-parts":[[1978,6]]}},"alternative-id":["10.1136\/jcp.31.6.551"],"URL":"https:\/\/doi.org\/10.1136\/jcp.31.6.551","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1978,6]]}}}