{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:20:07Z","timestamp":1767907207140,"version":"3.49.0"},"reference-count":34,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1978,6]]},"abstract":"<jats:p>Ten out of 164 cases of bronchogenic carcinoma showed pathological evidence at necropsy of the ectopic ACTH syndrome. All occurred in association with oat-cell carcinoma, constituting 19% of that group. The pathological features consisted of adrenocortical hyperplasia confined to the zona fasciculata and Crooke's hyaline change in the pituitary. Immunoperoxidase stainable ACTH was detected in the pituitary but not in the carcinoma tissue, a surprising finding, which may be due to the different nature of ACTH present in tumour tissue. The ectopic ACTH syndrome was diagnosed ante mortem in only four out of 10 patients on the basis of hypokalaemia and metabolic alkalosis. The lack of clinical pointers in all but terminal cases is discussed as well as possible measures for earlier diagnosis.<\/jats:p>","DOI":"10.1136\/jcp.31.6.591","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"591-598","source":"Crossref","is-referenced-by-count":26,"title":["Ectopic ACTH syndrome: clinicopathological correlations."],"prefix":"10.1136","volume":"31","author":[{"given":"W","family":"Singer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,6,1]]},"reference":[{"key":"ref_1","first-page":"279","article-title":"Ectopic production of big ACTH in carcinoma of the lung. 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Cancer, 22, 274-286.","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/bjc.1970.90","article-title":"Fine structure of an oat cell carcinoma of the lung associated with ectopic ACTH syndrome","volume":"24","author":"Corrin, B.; MacMillan, M.","year":"1970","unstructured":"Corrin, B., and MacMillan, M. (1970). Fine structure of an oat cell carcinoma of the lung associated with ectopic ACTH syndrome. British Journal of Cancer, 24, 755-758.","journal-title":"British Journal of Cancer"},{"key":"ref_4","article-title":"Ectopic ACTH production in carcinoma of the lung","author":"Gewirtz, G.; Yalow, R.S.","year":"1974","unstructured":"Gewirtz, G., and Yalow, R. S. (1974). Ectopic ACTH production in carcinoma of the lung. Journal of Clinical","journal-title":"Journal of Clinical"},{"key":"ref_5","first-page":"318","article-title":"The natural history of hyalinization of ACTH-MSH cells in man","volume":"91","unstructured":"The natural history of hyalinization of ACTH-MSH cells in man. Archives of Pathology, 91, 318-326.","journal-title":"Archives of Pathology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/1097-0142(197601)37:1<377::AID-CNCR2820370148>3.0.CO;2-L","article-title":"Gastric carcinoid with ectopic production of ACTH and P-MSH","volume":"37","author":"Hirata, Y.; Sakamoto, N.; Yamamoto, H.; Matsukura, S.; Imura, H.; Okada, S.","year":"1976","unstructured":"Hirata, Y., Sakamoto, N., Yamamoto, H., Matsukura, S., Imura, H., and Okada, S. (1976). Gastric carcinoid with ectopic production of ACTH and P-MSH. 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American Journal of Medicine, 53, 521-528.","journal-title":"American Journal of Medicine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2265.1972.tb00375.x","article-title":"Tumour and plasma ACTH concentrations in patients with and without the ectopic ACTH syndrome","volume":"1","author":"Ratcliffe, J.G.; Knight, R.A.; Besser, G.M.; Landon, J.; Stansfeld, A.G.","year":"1972","unstructured":"Ratcliffe, J. G., Knight, R. A., Besser, G. M., Landon, J. and Stansfeld, A. G. (1972) Tumour and plasma ACTH concentrations in patients with and without the ectopic ACTH syndrome. Clinical Endocrinology, 1, 27-44.","journal-title":"Clinical Endocrinology"},{"key":"ref_25","article-title":"Electron microscopy of an","author":"Rawlinson, D.G.","year":"1973","unstructured":"Rawlinson, D. G. (1973). 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(1975). Ectopic hormone production."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/18.5.315","article-title":"The unlabelled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes","volume":"18","author":"Sternberger, L.A.; Hardy, Jr., P.H.; Cuculis, J.J.; Meyer, H.G.","year":"1970","unstructured":"Sternberger, L. A., Hardy, P. H., Jr., Cuculis, J. J., and Meyer, H. G. (1970). The unlabelled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. 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Evidence for the presence of tumor peptides with corticotropin-releasing-factor-like activity in the ectopic ACTH syndrome. New England Journal of Medicine, 285, 419-424.","journal-title":"New England Journal of Medicine"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.31.6.591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:34:26Z","timestamp":1765694066000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.31.6.591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,6]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1978,6,1]]},"published-print":{"date-parts":[[1978,6]]}},"alternative-id":["10.1136\/jcp.31.6.591"],"URL":"https:\/\/doi.org\/10.1136\/jcp.31.6.591","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,6]]}}}