{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:44:14Z","timestamp":1759009454336,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1979,10]]},"abstract":"<jats:p>The following sera were tested for EB virus-specific IgA: serial sera from 61 cases of infectious mononucleosis (IM) and from 195 EBV IgG positive healthy students; single sera from each of 1469 persons of different ages, 63 cases of untreated Hodgkin's disease, and 22 neonates. EBV specific IgA was found in the sera from 88% of cases of IM, from 18.5% of EBV IgG positive healthy students, and in 13.5% of repeat samples from the same students three years later. The incidence of EBV IgA varied from 5 to 30% at different ages in single sera from EBV IgG positive persons aged 2 to 70 years. The higher percentages occurred in the age groups where recent sero-conversion rates were high. Fifteen percent of sera from cases of Hodgkin's disease were positive for EBV IgA, an incidence similar to that for healthy adults in the age group 25-45 years. None of the EBV IgG positive sera from neonates gave a positive reaction for EBV IGA.<\/jats:p>","DOI":"10.1136\/jcp.32.10.1036","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1036-1040","source":"Crossref","is-referenced-by-count":16,"title":["EB virus-specific IgA in serum of patients with infectious mononucleosis and of healthy people of different ages."],"prefix":"10.1136","volume":"32","author":[{"given":"J M","family":"Edwards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Woodroof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1136\/jcp.29.9.841","article-title":"Measurement of heterophil antibody and antibodies to EB viral capsid antigen IgG and IgM in suspected cases of infectious mononucleosis","volume":"29","author":"Blake, J.M.; Edwards, J.M.B.; Fletcher, W.; McSwiggan, D.A.; Pereira, M.S.","year":"1976","unstructured":"Blake, J. M., Edwards, J. M. B., Fletcher, W., McSwiggan, D. A., and Pereira, M. S. (1976). Measurement of heterophil antibody and antibodies to EB viral capsid antigen IgG and IgM in suspected cases of infectious mononucleosis. Journal of Clinical Pathology, 29, 841-847.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/jcp.27.8.647","article-title":"Studies on the diagnostic value of an immunofluorescence test for EB virus-specific IgM","volume":"27","author":"Edwards, J.M.B.; McSwiggan, D.A.","year":"1974","unstructured":"Edwards, J. M. B., and McSwiggan, D. A. (1974). Studies on the diagnostic value of an immunofluorescence test for EB virus-specific IgM. Journal of Clinical Pathology, 27, 647-651.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.2910170102","article-title":"Epstein-Barr virusspecific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma","volume":"17","author":"Henle, G.; Henle, W.","year":"1976","unstructured":"Henle, G., and Henle, W. (1976). Epstein-Barr virusspecific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma. International Journal ofCancer, 17, 1-7.","journal-title":"International Journal ofCancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/bjc.1976.228","article-title":"Epstein-Barr virus-specific IgA and IgG serum antibodies in nasopharyngeal carcinoma","volume":"34","author":"Ho, H.C.; Kwan, H.C.; Ng, M.H.; Chau, J.C.","year":"1976","unstructured":"Ho, H. C., Kwan, H. C., Ng, M. H., and Chau, J. C. (1976). Epstein-Barr virus-specific IgA and IgG serum antibodies in nasopharyngeal carcinoma. British Journal ofCancer, 34, 655-660.","journal-title":"British Journal ofCancer"},{"key":"ref_5","first-page":"436","article-title":"Serum IgA antibodies to Epstein-Barr virus capsid antigen preceding symptoms of nasopharyngeal carcinoma (Letter)","volume":"1","author":"Ho, H.C.; Kwan, H.C.; Ng, M.H.; de-The, G.","year":"1978","unstructured":"Ho, H. C., Kwan, H. C., Ng, M. H., and de-The, G. (1978). Serum IgA antibodies to Epstein-Barr virus capsid antigen preceding symptoms of nasopharyngeal carcinoma (Letter). Lancet, 1, 436.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/jcp.29.1.42","article-title":"Epstein-Barr virus antibody and infectious mononucleosis in a boarding school for boys","volume":"29","author":"Hoskins, T.W.; Fletcher, W.B.; Blake, J.M.; Pereira, M.S.; Edwards, J.M.B.","year":"1976","unstructured":"Hoskins, T. W., Fletcher, W. B., Blake, J. M., Pereira, M. S., and Edwards, J. M. B. (1976). Epstein-Barr virus antibody and infectious mononucleosis in a boarding school for boys. Journal of Clinical Pathology, 29, 42-45.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_7","first-page":"33","article-title":"Epstein-Barr virus infection in the neonatal period and in childhood","volume":"110","author":"Joncas, J.; Boucher, J.; Granger-Julien, M.; Filion, C.","year":"1974","unstructured":"Joncas, J., Boucher, J., Granger-Julien, M, and Filion, C. (1974). Epstein-Barr virus infection in the neonatal period and in childhood. Canadian Medical Association Journal, 110, 33-37.","journal-title":"Canadian Medical Association Journal"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0022-1759(73)90057-4","article-title":"The use of cord serum and indirect viral immunofluorescence as a method of evaluating the immunological specificity of fluorescein-labelled anti-human IgA conjugate","volume":"2","author":"Mawhinney, H.; Haire, M.; Adair, B.M.","year":"1973","unstructured":"Mawhinney, H., Haire, M., and Adair, B. M. (1973). The use of cord serum and indirect viral immunofluorescence as a method of evaluating the immunological specificity of fluorescein-labelled anti-human IgA conjugate. Journal of Immunological Methods, 2, 309-313.","journal-title":"Journal of Immunological Methods"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJM197302012880503","article-title":"Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis","volume":"288","author":"Miller, G.; Niederman, J.C.; Andrews, L.","year":"1973","unstructured":"Miller, G., Niederman, J. C., and Andrews, L. (1973). Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis. New Englanid Journal ofMedicine, 288, 229-232.","journal-title":"New Englanid Journal ofMedicine"},{"key":"ref_10","first-page":"22","article-title":"Infectious mononucleosis and Hodgkin's disease","author":"Mufnoz, N.; Davidson, R.J.L.; Witthoff, B.; Ericsson, J.E.; de-The, G.","year":"1978","unstructured":"Mufnoz, N., Davidson, R. J. L., Witthoff, B., Ericsson, J. E., and de-The, G. (1978). Infectious mononucleosis and Hodgkin's disease. International Journal of Cancer, 22,10-13.","journal-title":"International Journal of Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/bmj.4.5682.526","article-title":"Epstein-Barr virus antibody at different ages","volume":"4","author":"Pereira, M.S.; Blake, J.M.; Macrae, A.D.","year":"1969","unstructured":"Pereira, M. S., Blake, J. M., and Macrae, A. D. (1969). Epstein-Barr virus antibody at different ages. British Medical Journal, 4, 526-527.","journal-title":"British Medical Journal"},{"issue":"253-256","key":"ref_12","article-title":"Hodgkin's disease in patient with previous infectious mononucleosis: 30 years experience","volume":"2","author":"Rosdahl, N.; Olesen-Larson, S.; Clemmensen, J.","year":"1974","unstructured":"Rosdahl, N., Olesen-Larson, S., and Clemmensen, J. (1974). Hodgkin's disease in patient with previous infectious mononucleosis: 30 years experience. British Medical Journal, 2,253-256.","journal-title":"British Medical Journal"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/infdis\/131.4.403","article-title":"Seroepidemiologic study of Epstein-Barr virus infections in a rural community","volume":"131","author":"Sumaya, C.V.; Henle, W.; Henle, G.; Smith, M.H.D.; LeBlanc, D.","year":"1975","unstructured":"Sumaya, C. V., Henle, W., Henle, G., Smith, M. H. D., and LeBlanc, D. (1975). Seroepidemiologic study of Epstein-Barr virus infections in a rural community. Journal ofInfectious Diseases, 131, 403-408.","journal-title":"Journal ofInfectious Diseases"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/bmj.4.5788.643","article-title":"Infectious mononucleosis and its relationship to Epstein-Barr virus antibody","volume":"4","author":"University Health Physicians and Public Health Laboratory Service Laboratories","year":"1971","unstructured":"University Health Physicians and Public Health Laboratory Service Laboratories (1971). Infectious mononucleosis and its relationship to Epstein-Barr virus antibody. British Medical Journal, 4, 643-646.","journal-title":"British Medical Journal"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.32.10.1036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:59:32Z","timestamp":1758797972000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.32.10.1036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,10]]},"references-count":14,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1979,10,1]]},"published-print":{"date-parts":[[1979,10]]}},"alternative-id":["10.1136\/jcp.32.10.1036"],"URL":"https:\/\/doi.org\/10.1136\/jcp.32.10.1036","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1979,10]]}}}