{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:30:55Z","timestamp":1765704655198,"version":"3.48.0"},"reference-count":13,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1979,10]]},"abstract":"<jats:p>The blood lymphocytes of 37 splenectomised patients were analysed by means of T and B lymphocyte surface markers. Sixteen patients had had a splenectomy for non-haematological and 21 for haematological reasons. The results show that 15 had normal numbers of T and B cells; decreased T cells were found in two patients, raised B cells in seven, raised T and B cells in eight, and raised T cells in five patients. Increased numbers of 'null' cells were observed in some patients, especially in those with raised B cells. Follow-up studies indicate that raised levels of T and B cells can be established by one to three months post-splenectomy and may persist, although in some patients the cells fall to normal levels. The lymphocyte proliferative response to phytohaemagglutinin and Concanavalin A in vitro was normal in eight out of nine patients with raised T cells and was depressed in one patient, possibly due to an intrinsic cell defect.<\/jats:p>","DOI":"10.1136\/jcp.32.10.1045","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1045-1049","source":"Crossref","is-referenced-by-count":23,"title":["Changes in T and B blood lymphocytes after splenectomy."],"prefix":"10.1136","volume":"32","author":[{"given":"R E","family":"Millard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D K","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/jcp.27.10.767","article-title":"Cytochemical profile of B and T leukaemic lymphocytes with special reference to acute lymphoblastic leukaemia","volume":"27","author":"Catovsky, D.; Galetto, J.; Okos, A.; Miliani, E.; Galton, D.A.G.","year":"1974","unstructured":"Catovsky, D., Galetto, J., Okos, A., Miliani, E., and Galton, D. A. G. (1974). Cytochemical profile of B and T leukaemic lymphocytes with special reference to acute lymphoblastic leukaemia. Journal of Clinical Pathology, 27, 767-771.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_2","first-page":"417435","article-title":"An analytical study of splenectomised cases after traumatic rupture of healthy spleens","volume":"137","author":"Ek, J.I.; Rayner, S.","year":"1950","unstructured":"Ek, J. I., and Rayner, S. (1950). An analytical study of splenectomised cases after traumatic rupture of healthy spleens. Acta Medica Scandinavica, 137, 417435.","journal-title":"Acta Medica Scandinavica"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/195297a0","article-title":"Acid phosphatase activity in human blood cells","volume":"195","author":"Goldberg, A.F.; Barka, T.","year":"1962","unstructured":"Goldberg, A. F., and Barka, T. (1962). Acid phosphatase activity in human blood cells. 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Journal of Immunology, 114, 116-119.","journal-title":"Journal of Immunology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2141.1968.tb01489.x","article-title":"The effect of splenectomy on the leucocyte count","volume":"14","author":"McBride, J.A.; Dacie, J.V.; Shapley, R.","year":"1968","unstructured":"McBride, J. A., Dacie, J. V., and Shapley, R. (1968). The effect of splenectomy on the leucocyte count. British Journal ofHaematology, 14, 225-231.","journal-title":"British Journal ofHaematology"},{"key":"ref_10","series-title":"Acta Chirurgica Scandinavica; Report of a WHO\/IARCSponsored Workshop on Human B and T cells","first-page":"89","article-title":"On the late effects of removal of the normal speen","volume":"131","author":"Pedersen, B.; Videbaek, A.","year":"1966","unstructured":"Pedersen, B., and Videbaek, A. (1966). On the late effects of removal of the normal speen. Acta Chirurgica Scandinavica, 131, 89-98. WHO\/IARC Report (1974). Report of a WHO\/IARCSponsored Workshop on Human B and T cells, London, July 1974."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-3083.1974.tb01285.x","article-title":"T lymphocytes from human peripheral blood","volume":"3","unstructured":"Identification, enumeration and isolation of B and T lymphocytes from human peripheral blood. Scandinavian Journal of Immunology, 3, 521-532.","journal-title":"Scandinavian Journal of Immunology"},{"key":"ref_12","first-page":"1210","article-title":"IgG on lymphocyte surfaces: technical problems and the significance of a third cell population","volume":"114","author":"Winchester, R.J.; Fu, S.M.; Hoffman, T.; Kunkel, H.G.","year":"1975","unstructured":"Winchester, R. J., Fu, S. M., Hoffman, T., and Kunkel, H. G. (1975). IgG on lymphocyte surfaces: technical problems and the significance of a third cell population. Journal of Immunology, 114, 1210-1212.","journal-title":"Journal of Immunology"},{"key":"ref_13","first-page":"126","article-title":"Isolation of normal T cells in chronic lymphatic leukaemia","volume":"1","author":"Wybran, J.; Chantler, S.; Fudenberg, H.H.","year":"1973","unstructured":"Wybran, J., Chantler, S., and Fudenberg, H. H. (1973). Isolation of normal T cells in chronic lymphatic leukaemia. Lancet, 1, 126-129.","journal-title":"Lancet"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.32.10.1045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:27:24Z","timestamp":1765704444000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.32.10.1045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,10]]},"references-count":13,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1979,10,1]]},"published-print":{"date-parts":[[1979,10]]}},"alternative-id":["10.1136\/jcp.32.10.1045"],"URL":"https:\/\/doi.org\/10.1136\/jcp.32.10.1045","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1979,10]]}}}