{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:55:47Z","timestamp":1765709747966,"version":"3.48.0"},"reference-count":31,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1979,12]]},"abstract":"<jats:p>Paraffin sections of a variety of tissues from 12 patients with typical hairy-cell leukaemia (HCL) were stained for immunoglobulin heavy and light chains by the peroxidase-antiperoxidase (PAP) technique. Plasma cells were frequent, particularly in a lymph node from a severely infected patient. The reactive nature of the plasma cells of HCL was suggested by the fact that there was no restriction of light-chain expression, although viable hairy cells were shown to express monoclonal surface immunoglobulin. This, together with the absence by both light and electron microscopy of forms intermediate between hairy cells and plasma cells and the lack of ribosome-lamella complexes in the plasma cells, suggested that hairy cells do not differentiate into plasma cells. Although hairy cells are known to contain immunoglobulin, this was not demonstrable in hairy cells in the paraffin-embedded tissue. The PAP technique was also useful for demonstrating abundant splenic macrophages in HCL.<\/jats:p>","DOI":"10.1136\/jcp.32.12.1244","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1244-1247","source":"Crossref","is-referenced-by-count":4,"title":["Hairy-cell leukaemia: an immunoperoxidase study of paraffin-embedded tissues."],"prefix":"10.1136","volume":"32","author":[{"given":"J H","family":"Gooi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G F","family":"Burns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Cawley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/1097-0142(197801)41:1<210::AID-CNCR2820410130>3.0.CO;2-Y","article-title":"Structural and functional properties of the 'hairy' cells of leukemic reticuloendotheliosis","volume":"41","author":"Braylan, R.C.; Jaffe, E.S.; Triche, T.J.; Nanba, K.; Fowlkes, B.J.; Metzger, H.; Frank, M.M.; Dolan, M.S.; Yee, C.L.; Green, I.; Berard, C.W.","year":"1978","unstructured":"Braylan, R. C., Jaffe, E. S., Triche, T. J., Nanba, K., Fowlkes, B. J., Metzger, H., Frank, M. M., Dolan, M. S., Yee, C. L., Green, I., and Berard, C. W. (1978). Structural and functional properties of the 'hairy' cells of leukemic reticuloendotheliosis. Cancer, 41, 210-227.","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0308-2261(21)00556-7","article-title":"Chronic lymphocytic leukaemia as an immunoproliferative disorder","volume":"6","author":"Brouet, J.C.; Seligmann, M.","year":"1977","unstructured":"Brouet, J. C., and Seligmann, M. (1977). Chronic lymphocytic leukaemia as an immunoproliferative disorder. Clinics in Haematology, 6, 169-184.","journal-title":"Clinics in Haematology"},{"key":"ref_3","first-page":"565","article-title":"Ribosome-lamella complexes in neoplastic haematopoietic cells","volume":"79","author":"Brunning, R.D.; Parkin, J.","year":"1975","unstructured":"Brunning, R. D., and Parkin, J. (1975). Ribosome-lamella complexes in neoplastic haematopoietic cells. American Journal of Pathology, 79, 565-572.","journal-title":"American Journal of Pathology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0145-2126(78)90005-X","article-title":"Hairy-cell leukaemia: a B-cell neoplasm with a severe deficiency of circulating normal B lymphocytes","volume":"2","author":"Burns, G.F.; Cawley, J.C.; Higgy, K.E.; Barker, C.R.; Edwards, M.; Rees, J.K.H.; Hayhoe, F.G.J.","year":"1978","unstructured":"Burns, G. F., Cawley, J. C., Higgy, K. E., Barker, C. R., Edwards, M., Rees, J. K. H., and Hayhoe, F. G. J. (1978a). Hairy-cell leukaemia: a B-cell neoplasm with a severe deficiency of circulating normal B lymphocytes. Leukemia Research, 2, 33-40.","journal-title":"Leukemia Research"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1182\/blood.V52.6.1132.1132","article-title":"Multiple heavy chain isotypes on the surface of the cells of hairy-cell leukemia","volume":"52","author":"Burns, G.F.; Cawley, J.C.; Worman, C.P.; Karpas, A.; Barker, C.R.; Goldstone, A.H.; Hayhoe, F.G.J.","year":"1978","unstructured":"Burns, G. F., Cawley, J. C., Worman, C. P., Karpas, A., Barker, C. R., Goldstone, A. H., and Hayhoe, F. G. J. (1978b). Multiple heavy chain isotypes on the surface of the cells of hairy-cell leukemia. Blood, 52, 1132-1147.","journal-title":"Blood"},{"key":"ref_6","first-page":"616","article-title":"Typical hairy-cell leukaemia with IgGK paraprotein (abstract)","volume":"41","author":"Cawley, J.C.; Bums, G.F.; Bevan, A.; Worman, C.P.; Smith, J.L.; Gray, L.; Barker, C.R.; Hayhoe, F.G.J.","year":"1979","unstructured":"Cawley, J. C., Bums, G. F., Bevan, A., Worman, C. 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M., Winchester, R. 3., Rai, K. R., and Kunkel, H. G. (1974). Hairy cell leukemia: proliferation of a cell with phagocytic and B-lymphocyte properties. Scandinavian Journal of Immunology, 3, 847-851.","journal-title":"Scandinavian Journal of Immunology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1365-2141.1977.tb00595.x","article-title":"Immunoglobulin synthesis in hairy cell leukaemia","volume":"35","author":"Golde, D.W.; Stevens, R.H.; Quan, S.G.; Saxon, A.","year":"1977","unstructured":"Golde, D. W., Stevens, R. H., Quan, S. G., and Saxon, A. (1977). Immunoglobulin synthesis in hairy cell leukaemia. British Journal of Haematology, 35, 359-365.","journal-title":"British Journal of Haematology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"677","DOI":"10.7326\/0003-4819-89-5-677","article-title":"Hairy cell leukemia","volume":"89","author":"Golomb, H.M.; Catovsky, D.; Golde, D.W.","year":"1978","unstructured":"Golomb, H. 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Distribution of transferrin, ferritin, and lactoferrin in human tissues, Journal of Clinical Pathology, 31, 316-327.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/1097-0142(197706)39:6<2323::AID-CNCR2820390602>3.0.CO;2-C","article-title":"Hairy cell leukemia: enzyme histochemical characterization, with special reference to splenic stromal changes","volume":"39","author":"Nanba, K.; Jaffe, E.S.; Soban, E.J.; Braylan, R.C.; Berard, C.W.","year":"1977","unstructured":"Nanba, K., Jaffe, E. S., Soban, E. J., Braylan, R. C., and Berard, C. W. (1977). Hairy cell leukemia: enzyme histochemical characterization, with special reference to splenic stromal changes. 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A., and Gut, D. (1975). Virus-bearing plasma cells in peripheral blood of a patient with \"hairy cell leukemia\". Acta Haematologica, 54, 297-305.","journal-title":"Acta Haematologica"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2141.1979.tb01122.x","article-title":"Hairy cell leukaemia: surface markers and functional capacities of the leukaemic cells analysed in eight patients","volume":"42","author":"Rieber, E.P.; Hadam, M.R.; Linke, R.P.; Saal, J.G.; Riethmiuller, G.; von Heyden, H.W.; Waller, H.D.","year":"1979","unstructured":"Rieber, E. P., Hadam, M. R., Linke, R. P., Saal, J. G., Riethmiuller, G., von Heyden, H. W., and Waller, H. D. (1979). Hairy cell leukaemia: surface markers and functional capacities of the leukaemic cells analysed in eight patients. 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(1971). Tartrateresistant acid phosphatase isoenzyme in the reticulum cells of leukemic reticuloendotheliosis. 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