{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:54:39Z","timestamp":1765713279808,"version":"3.48.0"},"reference-count":26,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1979,2]]},"abstract":"<jats:p>Diagnostic bone marrow smears from 132 patients with acute lymphoblastic leukaemia, (ALL) were stained simultaneously by the periodic acid-Schiff (PAS) reaction, and the blast cell positivity was assessed quantitatively. The patients fell naturally into two unequal groups: those with more than 20% PAS-positive blast cells (44 patients) and those with less (88 patients). There was no relation between the degree of positivity and age, sex, or presenting leucocyte count. Actuarial survival studies showed that the group with more than 20% PAS-positive blast cells survived longer, but that this difference assumed statistical significance only after the exclusion of patients over 14 years old and those with high white cell counts at the time of diagnosis. It appears that the PAS reaction can identify long survivors among patients with ALL, but not in the absence of features strongly associated with a poor prognosis.<\/jats:p>","DOI":"10.1136\/jcp.32.2.158","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"158-161","source":"Crossref","is-referenced-by-count":5,"title":["Periodic acid-Schiff reaction and prognosis in lymphoblastic leukaemia."],"prefix":"10.1136","volume":"32","author":[{"given":"J S","family":"Lilleyman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Sugden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Britton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,2,1]]},"reference":[{"key":"ref_1","first-page":"300","article-title":"On the usefulness of PAS reaction for the prognosis of acute lymphoblastic leukemia","volume":"60","author":"Ascari, E.; Marini, G.; Invernizzi, R.; Ippolita, G.; Casirola, G.; Fontana, G.; Rizzo, S.C.","year":"1975","unstructured":"Ascari, E., Marini, G., Invernizzi, R., Ippolita, G., Casirola, G., Fontana, G., and Rizzo, S. C. (1975). On the usefulness of PAS reaction for the prognosis of acute lymphoblastic leukemia. Haematologica, 60, 300-307.","journal-title":"Haematologica"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0140-6736(78)91509-X","article-title":"Sex and prognosis in childhood acute lymphoblastic leukaemia","volume":"2","author":"Baumer, J.H.; Mott, M.G.","year":"1978","unstructured":"Baumer, J. H., and Mott, M. G. (1978). Sex and prognosis in childhood acute lymphoblastic leukaemia. Lancet, 2, 128-129.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/bmj.2.5655.513-a","article-title":"Lymphoblastic leukaemia (letter)","volume":"2","author":"Bennett, J.M.; Henderson, E.S.","year":"1969","unstructured":"Bennett, J. M., and Henderson, E. S. (1969). Lymphoblastic leukaemia (letter). British Medical Journal, 2, 513.","journal-title":"British Medical Journal"},{"key":"ref_4","first-page":"633","article-title":"Application des techniques cytochimiques A 47 cas de leucemies aiguds: modifications cytochimiques au cours de l'evolution","volume":"49","author":"Berrebi, A.; Malaskova, V.; Oberling, F.; Mayer, S.","year":"1973","unstructured":"Berrebi, A., Malaskova, V., Oberling, F., and Mayer, S. (1973). Application des techniques cytochimiques A 47 cas de leucemies aiguds: modifications cytochimiques au cours de l'evolution. Semaine des Hopitaux de Paris, 49, 633-643.","journal-title":"Semaine des Hopitaux de Paris"},{"key":"ref_5","first-page":"1307","article-title":"Acute lymphoblastic leukaemia in children: classification and prognosis","volume":"2","author":"Chessells, J.M.; Hardisty, R.M.; Rapson, N.T.; Greaves, M.F.","year":"1977","unstructured":"Chessells, J. M., Hardisty, R. M., Rapson, N. T., and Greaves, M. F. (1977). 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The cytology and cytochemistry of acute leukaemias. Special Report Series, Medical Research Council, 304.","journal-title":"Special Report Series, Medical Research Council"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2141.1960.tb06212.x","article-title":"Consecutive use of Romanowsky and periodicacid-Schiff techniques in the study of blood and bonemarrow cells","volume":"6","author":"Hayhoe, F.G.; Quaglino, J.; D.; Flemans, R.J.","year":"1960","unstructured":"Hayhoe, F. G., J. Quaglino, D., and Flemans, R. J. (1960). Consecutive use of Romanowsky and periodicacid-Schiff techniques in the study of blood and bonemarrow cells. 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II. Analysis and examples. British Journal of Cancer, 35, 1-39.","journal-title":"II. Analysis and examples. British Journal of Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ajh.2830020305","article-title":"Lack of prognostic value of the periodic acid-Schiff reaction and blast cell size in childhood acute lymphocytic leukemia","volume":"2","author":"Shaw, M.T.; Humphrey, G.B.; Lawrence, R.; Fischer, D.B.","year":"1977","unstructured":"Shaw, M. T., Humphrey, G. B., Lawrence, R., and Fischer, D. B. (1977). Lack of prognostic value of the periodic acid-Schiff reaction and blast cell size in childhood acute lymphocytic leukemia. 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BROWN"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.32.2.158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:52:13Z","timestamp":1765713133000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.32.2.158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,2]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1979,2,1]]},"published-print":{"date-parts":[[1979,2]]}},"alternative-id":["10.1136\/jcp.32.2.158"],"URL":"https:\/\/doi.org\/10.1136\/jcp.32.2.158","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1979,2]]}}}