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It is suggested that the inclusions resulted from the combined effects of the S phenotype and alcohol and, on the basis of the known chemistry of the variant antitrypsins, that the lowered serum concentration of antitrypsin associated with the S allele may be due to hepatic holdup.<\/jats:p>","DOI":"10.1136\/jcp.32.7.706","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"706-709","source":"Crossref","is-referenced-by-count":12,"title":["Alpha-1-antitrypsin Pi S phenotype and liver cell inclusion bodies in alcoholic hepatitis."],"prefix":"10.1136","volume":"32","author":[{"given":"J K","family":"Kelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T V","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Milford-Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1126\/science.1198096","article-title":"Alcoholic hepatomegaly; accumulation of protein in the liver","volume":"190","author":"Baraona, E.; Leo, M.A.; Borowsky, S.A.; Lieber, C.S.","year":"1975","unstructured":"Baraona, E., Leo, M. 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