{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:40:01Z","timestamp":1758822001380,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1980,10]]},"abstract":"<jats:p>We report red cell indices and haemoglobin (Hb)A2 levels in Sardinian children with heterozygous beta 0-thalassaemia and in normal controls aged 6 months to 12 years. Iron-deficient children and those with haematological findings indicative of alpha-thalassaemia were excluded. As in adult carriers, these subjects have significantly increased mean red cell counts and significantly reduced mean Hb levels, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), haematocrit, and mean corpuscular haemoglobin concentration. From 66 to 76% of the heterozygous beta 0 thalassaemia children examined were anaemic. MCH and MCV were within the normal range in 2.8% of these children. Serum ferritin levels showed no difference from those of normal controls.<\/jats:p>","DOI":"10.1136\/jcp.33.10.946","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"946-948","source":"Crossref","is-referenced-by-count":3,"title":["Haematological characteristics of the beta 0 thalassaemia trait in Sardinian children."],"prefix":"10.1136","volume":"33","author":[{"given":"R","family":"Galanello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"De Virgiliis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Addis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Paglietti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Ruggeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,10,1]]},"reference":[{"key":"ref_1","article-title":"The Thalassaemia Syndromes","author":"Weatherall, D.J.; Clegg, J.B.","year":"1972","unstructured":"Weatherall DJ, Clegg JB. The Thalassaemia Syndromes. 2nd ed. Oxford: Blackwell Scientific Publications, 1972.","edition":"2nd ed"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1365-2141.1969.tb00435.x","article-title":"The hematological effects of glucose-6-phosphate dehydrogenase deficiency and thalassemia trait: interaction between the two genes at the phenotype levels","volume":"16","author":"Piomelli, S.; Siniscalco, M.","year":"1969","unstructured":"Piomelli S, Siniscalco M. The hematological effects of glucose-6-phosphate dehydrogenase deficiency and thalassemia trait: interaction between the two genes at the phenotype levels. Br J Haematol 1969;16:537-49.","journal-title":"Br J Haematol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1136\/bmj.3.5872.150","article-title":"Thalassaemia in the British","volume":"3","author":"Knox-Macaulay, H.H.M.; Weatherall, D.J.; Clegg, J.B.; Pembrey, M.E.","year":"1973","unstructured":"Knox-Macaulay HHM, Weatherall DJ, Clegg JB, Pembrey ME. Thalassaemia in the British. Br MedJ 1973;3: 150-5.","journal-title":"Br MedJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1365-2141.1973.tb01697.x","article-title":"Haematological data in 312 cases of 0-thalassaemia trait in Thailand","volume":"24","author":"Pootrakul, P.; Wasi, P.; Na-Nakorn, S.","year":"1973","unstructured":"Pootrakul P, Wasi P, Na-Nakorn S. Haematological data in 312 cases of 0-thalassaemia trait in Thailand. Br J Haematol 1973;24:703-12.","journal-title":"Br J Haematol"},{"key":"ref_5","first-page":"1","article-title":"thalassemia trait: hematological and hemoglobin synthesis studies","year":"1976","unstructured":"thalassemia trait: hematological and hemoglobin synthesis studies. Hemoglobin 1976-77;1:75-83.","journal-title":"Hemoglobin"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2141.1977.tb00636.x","article-title":"Comparison of haematological features of the 90 and 0+ thalassemia traits in Jamaican Negroes","volume":"36","author":"Millard, D.P.; Mason, K.; Serjeant, B.E.; Serjeant, G.R.","year":"1977","unstructured":"Millard DP, Mason K, Serjeant BE, Serjeant GR. Comparison of haematological features of the 90 and 0+ thalassemia traits in Jamaican Negroes. Br J Haematol 1977;36:161-70.","journal-title":"Br J Haematol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/03630267909069153","article-title":"0\u00b0 thalassemia trait in Sardinia","volume":"3","author":"Galanello, R.; Melis, M.A.; Ruggeri, R.","year":"1979","unstructured":"Galanello R, Melis MA, Ruggeri R, et al. 0\u00b0 thalassemia trait in Sardinia. Hemoglobin 1979;3:33-46.","journal-title":"Hemoglobin"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/jmg.15.6.443","article-title":"Thalassaemia types and their incidence in Sardinia","volume":"15","author":"Cao, A.; Galanello, R.; Muroni, P.P.","year":"1978","unstructured":"Cao A, Galanello R, Muroni PP, et al. Thalassaemia types and their incidence in Sardinia. J Med Genet 1978;15: 443-7.","journal-title":"J Med Genet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S0022-3476(77)80427-7","article-title":"New approaches to screening for iron deficiency","volume":"90","author":"Dallmann, PR","year":"1977","unstructured":"Dallmann PR. New approaches to screening for iron deficiency. J Pediat 1977;90:678-80.","journal-title":"J Pediat"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1182\/blood.V43.4.581.581","article-title":"Ferritin in serum: diagnosis of iron deficiency and iron overload in infants and children","volume":"43","year":"1974","unstructured":"Siimes MA, Addiego JE, Dallmann PR. Ferritin in serum: diagnosis of iron deficiency and iron overload in infants and children. Blood 1974;43:581-90.","journal-title":"Blood"},{"key":"ref_11","first-page":"96","article-title":"Determination of serum iron and iron binding capacity without deproteinization","volume":"3","author":"Lauber, K.","year":"1965","unstructured":"Lauber K. Determination of serum iron and iron binding capacity without deproteinization. Z Klin Chem 1965; 3:96-9.","journal-title":"Z Klin Chem"},{"key":"ref_12","first-page":"700","article-title":"Microchromatography of haemoglobins. IlI A simplified procedure for the determination of haemoglobin A2","volume":"86","author":"Huisman, T.H.J.; Schroeder, W.A.; Brodie, A.N.; Mayson, S.M.; Jakway, J.","year":"1975","unstructured":"Huisman THJ, Schroeder WA, Brodie AN, Mayson SM, Jakway J. Microchromatography of haemoglobins. IlI A simplified procedure for the determination of haemoglobin A2. J Lab Clin Med 1975;86:700-2.","journal-title":"J Lab Clin Med"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.33.10.946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:26:07Z","timestamp":1758821167000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.33.10.946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,10]]},"references-count":12,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1980,10,1]]},"published-print":{"date-parts":[[1980,10]]}},"alternative-id":["10.1136\/jcp.33.10.946"],"URL":"https:\/\/doi.org\/10.1136\/jcp.33.10.946","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1980,10]]}}}