{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:28:14Z","timestamp":1765729694359,"version":"3.48.0"},"reference-count":12,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1980,6]]},"abstract":"<jats:p>Cervical smears were reviewed from patients in whom a cytological abnormality was followed, after an interval without interference, either by regression to `negative' or else by progression to invasive carcinoma. Twenty-eight cases were from a previously analysed series with positive smears and an interval of at least two years before investigation, resulting from refusal or failure to trace. Slides were also reviewed from 25 cases in which `positive' smears had regressed to negative without escaping from surveillance, and from 10 patients subsequently developing invasive carcinoma whose previous slides, taken several years earlier, showed abnormalities on review. None of these 63 patients had any biopsy or other surgical procedure to the cervix between the initial smear and the outcome.<\/jats:p>\n                  <jats:p>Slides showing `superficial cell dyskaryosis' and\/or well-differentiated `parabasal cell dyskaryosis' were found only among the groups with subsequent regression. Those showing dissociated poorly differentiated dyskaryotic parabasal cells regressed to negative in two cases and progressed to invasion in nine. This suggests that many examples of spontaneous regression correspond to mild dysplasias which are not precancerous, and overdiagnosis must often have resulted in unnecessary surgical procedures in the past.<\/jats:p>\n                  <jats:p>`Regressing' and `progressing' groups both included cases in which the spatula had removed coherent pieces of undifferentiated epithelium. These are difficult to interpret cytologically. In nine of them (including four which regressed) the cytological picture was that of carcinoma in situ. The remainder (14 cases) were probably examples of reserve cell hyperplasia, and it is noteworthy that, of the 21 cases subsequently progressing to invasive carcinoma, five were preceded by appearances of this type. It is concluded that cell aggregates suggesting an unusual degree of reserve cell hyperplasia are a danger signal and require careful surveillance.<\/jats:p>","DOI":"10.1136\/jcp.33.6.517","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"517-525","source":"Crossref","is-referenced-by-count":29,"title":["Progression and regression of cervical lesions"],"prefix":"10.1136","volume":"33","author":[{"given":"AI","family":"Spriggs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MM","family":"Boddington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/0002-9378(69)90268-3","article-title":"A follow-up study of patients with cervical dysplasia","volume":"105","author":"Richart, R.M.; Barron, B.A.","year":"1969","unstructured":"Richart RM, Barron BA. A follow-up study of patients with cervical dysplasia. Am J Obstet Gynecol 1969;105:386-93. 10Petersen 0. Precancerous changes of the cervical epithelium. Acta Radiol 1955; suppl 127.","journal-title":"Am J Obstet Gynecol; Precancerous changes of the cervical epithelium"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1002\/1097-0142(197812)42:6<2716::AID-CNCR2820420629>3.0.CO;2-1","article-title":"Relation of herpes simplex virus Type 2 antibodies and squamous dysplasia to cervical carcinoma in situ","volume":"42","author":"Thomas, D.B.; Rawls, W.E.","year":"1978","unstructured":"Thomas DB, Rawls WE. Relation of herpes simplex virus Type 2 antibodies and squamous dysplasia to cervical carcinoma in situ. Cancer 1978;42:2716-25.","journal-title":"Cancer"},{"key":"ref_3","article-title":"Diagnostic Cytology and its Histopathologic Bases","author":"Koss, L.G.","year":"1968","unstructured":"Koss LG. Diagnostic Cytology and its Histopathologic Bases, 2nd ed. Philadelphia: Lippincott, 1968.","edition":"2nd ed"},{"issue":"5","key":"ref_4","first-page":"142","article-title":"Exfoliative cytology of References reserve cell hyperplasia, basal cell hyperplasia and dysplasia","volume":"1961","author":"de Brux J; J, Dupre-Froment","unstructured":"de Brux J, Dupre-Froment J. Exfoliative cytology of References reserve cell hyperplasia, basal cell hyperplasia and dysplasia. Acta Cytol (Philadelphia) 1961;5:142-9.","journal-title":"Acta Cytol (Philadelphia)"},{"key":"ref_5","article-title":"Atlas of Exfoliative Cytology","author":"Papanicolaou, G.N.","year":"1954","unstructured":"Papanicolaou GN. Atlas of Exfoliative Cytology. Cambridge, Mass: Harvard University Press, 1954."},{"key":"ref_6","article-title":"Cytology of the Female Genital Tract. International Histological Classification of Tumours No.8","author":"Riotton, G.; Christopherson, W.M.","year":"1973","unstructured":"Riotton G, Christopherson WM. Cytology of the Female Genital Tract. International Histological Classification of Tumours No.8. Geneva: WHO, 1973."},{"key":"ref_7","article-title":"Diagnostic Cytopathology of the Uterine Cervix","author":"Patten, S.F.","year":"1978","unstructured":"Patten SF. Diagnostic Cytopathology of the Uterine Cervix, 2nd ed. Basle: Karger, 1978.","edition":"2nd ed"},{"key":"ref_8","article-title":"Early Histological Diagnosis of Cervical Cancer","author":"Burghardt, E.","year":"1973","unstructured":"Burghardt E. Early Histological Diagnosis of Cervical Cancer. Philadelphia: Saunders, 1973."},{"key":"ref_9","first-page":"213","article-title":"Some histological aspects of behavior of epidermoid carcinoma in situ and related lesions of the uterine cervix","volume":"17","author":"Koss, L.G.; Stewart, F.W.; Foote, F.W.; Jordan, M.J.; Bader, G.M.; Day, E.","year":"1963","unstructured":"Koss LG, Stewart FW, Foote FW, Jordan MJ, Bader GM, Day E. Some histological aspects of behavior of epidermoid carcinoma in situ and related lesions of the uterine cervix. Cancer 1963; 22 Johnson LD, Easterday CL, Gore H, Hertig AT. The histogenesis of carcinoma in situ of the uterine cervix. A preliminary report of the origin of carcinoma in situ in subcylindrical cell anaplasia. Cancer 1964;17:213-29.","journal-title":"Cancer; The histogenesis of carcinoma in situ of the uterine cervix. A preliminary report of the origin of carcinoma in situ in subcylindrical cell anaplasia"},{"issue":"6","key":"ref_10","first-page":"538","article-title":"Developmental stages of in situ carcinoma in uterine cervix: an analytical study of the cells","volume":"1962","author":"Reagan, J.W.; Seidemann, I.B.; Patten, Jr, S.F.","unstructured":"Reagan JW, Seidemann IB, Patten SF, Jr. Developmental stages of in situ carcinoma in uterine cervix: an analytical study of the cells. Acta Cytol (Philadelphia) 1962;6:538-46.","journal-title":"Acta Cytol (Philadelphia)"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0046-8177(77)80110-X","article-title":"Dysplasia, carcinoma in situ, and microinvasive carcinoma of the uterine cervix","volume":"8","author":"Christopherson, W.M.","year":"1977","unstructured":"Christopherson WM. Dysplasia, carcinoma in situ, and microinvasive carcinoma of the uterine cervix. Hum Pathol 1977;8:489-501.","journal-title":"Hum Pathol"},{"key":"ref_12","first-page":"305","article-title":"The identification of atypical reserve cells in smears of patients with premalignant and malignant changes in the squamous and glandular epithelium of the uterine cervix","volume":"22","author":"Beyer-Boon, M.E.; Verdonk, G.W.","year":"1978","unstructured":"Beyer-Boon ME, Verdonk GW. The identification of atypical reserve cells in smears of patients with premalignant and malignant changes in the squamous and glandular epithelium of the uterine cervix. Acta Cytol (Baltimore) 1978;22:305-1 1.","journal-title":"Acta Cytol (Baltimore)"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.33.6.517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:24:36Z","timestamp":1765729476000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.33.6.517"}},"subtitle":["Review of smears from women followed without initial biopsy or treatment"],"short-title":[],"issued":{"date-parts":[[1980,6]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1980,6,1]]},"published-print":{"date-parts":[[1980,6]]}},"alternative-id":["10.1136\/jcp.33.6.517"],"URL":"https:\/\/doi.org\/10.1136\/jcp.33.6.517","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1980,6]]}}}