{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:49:39Z","timestamp":1782258579285,"version":"3.54.5"},"reference-count":38,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1980,7]]},"abstract":"<jats:p>Platelet function was measured on 29 occasions in 16 adult patients in the asymptomatic steady state of sickle-cell anaemia. There was a significant increase in platelet number and micro-aggregate formation, and a lower aggregation threshold with adenosine diphosphate, compared with 23 healthy controls. Similar changes were found, however, in 12 splenectomised patients without sickle-cell diseases. The platelet hyperactivity of the sickle-cell steady state therefore reflects an increased circulating population of young, metabolically active platelets resulting from previous autosplenectomy.<\/jats:p>","DOI":"10.1136\/jcp.33.7.622","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"622-625","source":"Crossref","is-referenced-by-count":65,"title":["Platelet hyperactivity in sickle-cell disease: a consequence of hyposplenism."],"prefix":"10.1136","volume":"33","author":[{"given":"M W","family":"Kenny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Stuart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1980,7,1]]},"reference":[{"key":"ref_1","first-page":"235","article-title":"The liver in sickle cell anemia: a clinical-pathologic study","volume":"90","author":"Rosenblate, H.J.; Eisenstein, R.; Holmes, A.W.","year":"1970","unstructured":"Rosenblate HJ, Eisenstein R, Holmes AW. 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J Lab Clin Med 1972;80:385-94.","journal-title":"Arch Surg"},{"key":"ref_33","article-title":"Reports and Bulletins prepared by the Association of Clinical Biochemists The following reports and bulletins are published by the Association of Clinical Biochemists. They may be obtained from","unstructured":"Boxer MA, Braun J, Ellman L. Thromboembolic risk of postsplenectomy thrombocytosis. Arch Surg 1978; 113:808-9."},{"key":"ref_34","article-title":"The assessment of thyroid function","volume-title":"FV FLYNN and JR HOBBS","year":"1971","unstructured":"Reports and Bulletins prepared by the Association of Clinical Biochemists The following reports and bulletins are published by the Association of Clinical Biochemists. They may be obtained from The Publishing Department, British Medical Journal (ACB Technical Bulletins), BMA House, Tavistock Square, London WC1H 9JR. Overseas readers should remit by British Postal or Money Order."},{"key":"ref_35","article-title":"Renal function tests suitable for clinical practice","volume-title":"RWE WATTS 3 Biochemical tests for the assessment of fetoplacental function","author":"FL MITCHELL, N VEALL, and","year":"1972","unstructured":"The assessment of thyroid function March 1971 FV FLYNN and JR HOBBS"},{"key":"ref_36","article-title":"Test of exocrine pancreatic function","year":"1977","unstructured":"Renal function tests suitable for clinical practice January 1972 FL MITCHELL, N VEALL, and RWE WATTS 3 Biochemical tests for the assessment of fetoplacental function May 1975 CE WILDE and RE OAKEY"},{"key":"ref_37","article-title":"Control materials for clinical biochemistry","volume-title":"JF STEVENS","year":"1973","unstructured":"Test of exocrine pancreatic function March 1977","edition":"5th edition"},{"key":"ref_38","article-title":"Notes on the quality of performance of serum cholesterol assays September 1973 ss","unstructured":"Control materials for clinical biochemistry (5th edition) September 1973 JF STEVENS"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.33.7.622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:26:59Z","timestamp":1765078019000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.33.7.622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,7]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1980,7,1]]},"published-print":{"date-parts":[[1980,7]]}},"alternative-id":["10.1136\/jcp.33.7.622"],"URL":"https:\/\/doi.org\/10.1136\/jcp.33.7.622","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,7]]}}}