{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:32:42Z","timestamp":1765596762537,"version":"3.48.0"},"reference-count":11,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1981,10]]},"abstract":"<jats:p>Three cases of myocardial fibre calcification found at post-mortem examination are described. In one case there was antemortem hypercalcaemia and hyperphosphataemia and the case was clearly an example of metastatic calcification. In the other two cases there was ischaemic myocardial necrosis and calcification was seen in fibres which were not overtly necrotic, but which were both in proximity to (the majority) and remote from the necrotic zones. Since renal failure with hyperphosphataemia was present in both cases, these were considered to be examples of augmented (by the hyperphosphataemia) dystrophic calcification. The histological, histochemical and ultrastructural features were identical in the three cases. Hydroxyapatite formation was observed initially in mitochondria, followed by spillage of crystals into the cytosol and ultimately into the interstitium. It is suggested that the fundamental lesion is a dysfunction of the fibre membrane; the similarity of this reaction with the calcification seen in skeletal muscle fibres in various myopathies is noted and a unifying hypothesis of the mechanism of skeletal and cardiac muscle fibre calcification is thereby suggested.<\/jats:p>","DOI":"10.1136\/jcp.34.10.1167","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1167-1174","source":"Crossref","is-referenced-by-count":18,"title":["Myocardial fibre calcification."],"prefix":"10.1136","volume":"34","author":[{"given":"J","family":"McClure","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S","family":"Pieterse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J","family":"Pounder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P S","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0140-6736(76)92781-1","article-title":"Mitochondrial calcium overload: a general mechanism for cell necrosis in muscle diseases","volume":"i:","author":"Wrogemann, K.; Pena, S.D.J.","year":"1976","unstructured":"Wrogemann K, Pena SDJ. Mitochondrial calcium overload: a general mechanism for cell necrosis in muscle diseases. Lancet 1976;i:672-3.","journal-title":"Lancet"},{"key":"ref_2","first-page":"1662","article-title":"Inhibition of urine secretion and the production of renal calcinosis in the rat by acetazolamide (Diamox) administration","volume":"34","author":"Harrison, H.E.; Harrison, H.C.","year":"1955","unstructured":"Harrison HE, Harrison HC. Inhibition of urine secretion and the production of renal calcinosis in the rat by acetazolamide (Diamox) administration. J C\/in Ini'est 1955;34: 1662-70.","journal-title":"J C\/in Ini'est"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/0014-4827(56)90160-4","article-title":"Alkaline phosphatase and calcification in tuberculous lumph nodes","volume":"11","author":"Hendrichsen, T.","year":"1956","unstructured":"Hendrichsen T. Alkaline phosphatase and calcification in tuberculous lumph nodes. Exp Cell Res 1956;11:511-9.","journal-title":"Exp Cell Res"},{"article-title":"Metabolic Interrelationiships","year":"1949","key":"ref_4","unstructured":"Metabolic Interrelationiships. New York: Josiah Macy JR Foundation 1949."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.7326\/0003-4819-40-3-626","article-title":"Massive dystrophic calcification of myocardium","volume":"40","author":"Lasky, II","year":"1954","unstructured":"Lasky II. Massive dystrophic calcification of myocardium. Ann Intern Med 1954;40:626-31.","journal-title":"Ann Intern Med"},{"key":"ref_6","article-title":"Calcification in biologicail systems","year":"1960","unstructured":"Calcification in biologicail systems. Washington: Amer Assoc Adv Sci 1960.","journal-title":"Washington: Amer Assoc Adv Sci"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/0002-9343(71)90182-3","article-title":"Cardiac calcification in uraemia. A clinical, biochemical and pathological study","volume":"50","author":"Terman, D.S.; Alfrey, A.C.; Hammond, W.S.; Donndelinger, T.; Ogden, D.A.; Holmes, J.H.","year":"1971","unstructured":"Terman DS, Alfrey AC, Hammond WS, Donndelinger T, Ogden DA, Holmes JH. Cardiac calcification in uraemia. A clinical, biochemical and pathological study. Ain J Med 1971;50:744-55.","journal-title":"Ain J Med"},{"key":"ref_8","first-page":"1","article-title":"Calcification of the myocardium. Pathologic study of 13 cases","volume":"48","author":"Gore, I.; Arons, W.","year":"1949","unstructured":"Gore I, Arons W. Calcification of the myocardium. Pathologic study of 13 cases. Arch Pathol 1949;48:1-12.","journal-title":"Arch Pathol"},{"issue":"186","key":"ref_9","first-page":"\"260","article-title":"Rapid myocardial calcification after cardiac surgery","volume":"1963","author":"Hermann, G.; Haupt, G.J.; Birkhead, N.C.","year":"1968","unstructured":"Hermann G, Haupt GJ, Birkhead NC. Rapid myocardial calcification after cardiac surgery. JAMA 1963;186: 260-1. '\u00b0 Reichenbach DD, Benditt EP. Myofibrillar degeneration. A response of the myocardial cell to injury. Arch Pathol 1968;85:189-99.","journal-title":"JAMA; Reichenbach DD, Benditt EP. Myofibrillar degeneration. A response of the myocardial cell to injury"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/path.1710970422","article-title":"Metastatic calcification of the myocardium","volume":"97","author":"Woodhouse, M.A.; Burston, J.","year":"1969","unstructured":"Woodhouse MA, Burston J. Metastatic calcification of the myocardium. J Pathol 1969;97:733-6.","journal-title":"J Pathol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1093\/ajcp\/53.6.820","article-title":"Mitochondrial mineralisation in human myocardium","volume":"53","author":"D'Agostino, A.N.; Chiga, M.","year":"1970","unstructured":"D'Agostino AN, Chiga M. Mitochondrial mineralisation in human myocardium. Am J Clin Pathol 1970;53: 820-4.","journal-title":"Am J Clin Pathol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.34.10.1167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:28:24Z","timestamp":1765596504000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.34.10.1167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,10]]},"references-count":11,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1981,10,1]]},"published-print":{"date-parts":[[1981,10]]}},"alternative-id":["10.1136\/jcp.34.10.1167"],"URL":"https:\/\/doi.org\/10.1136\/jcp.34.10.1167","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1981,10]]}}}