{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:37:46Z","timestamp":1787017066553,"version":"build-2736575974"},"reference-count":12,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1981,10]]},"abstract":"<jats:p>Measurements of villus height, villus area, together with counts of epithelial cells in individual villi, were performed on endoscopic duodenal biopsies from five groups of patients: controls, ulcer-associated duodenitis, mild and severe non-specific (non-ulcerative) duodenitis, cimetidine healed ulcer-associated duodenitis and cimetidine healed non-specific duodenitis. The objectives of the study were two-fold: to establish if epithelial cell count correlated with simpler measurements of villus height or area; and to compare the findings in ulcer-associated and in  non-specific duodenitis. Villus area correlated well with epithelial cell count per villus (r = 0.96); villus height correlated less well (r = 0.66). When compared with controls, there was a significant decrease in the epithelial cell count per villus in ulcer-associated and severe non-specific duodenitis, but this was confined to the visually inflamed area of the duodenal bulb. After healing of inflammation with cimetidine villus height, area, and epithelial cell count returned to values similar to those in controls. This study confirms that the effects of ulcer-associated and severe non-specific duodenitis on duodenal villi are identical.<\/jats:p>","DOI":"10.1136\/jcp.34.10.1181","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1181-1186","source":"Crossref","is-referenced-by-count":41,"title":["Measurements of intestinal villi non-specific and ulcer-associated duodenitis-correlation between area of microdissected villus and villus epithelial cell count."],"prefix":"10.1136","volume":"34","author":[{"given":"M","family":"Hasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1981,10,1]]},"reference":[{"key":"ref_1","first-page":"241","article-title":"Control of intestinal epithelial replacement: lack of evidence for tissue-specific blood-borne factor","volume":"7","author":"Clarke, R.M.","year":"1974","unstructured":"Clarke RM. Control of intestinal epithelial replacement: lack of evidence for tissue-specific blood-borne factor. Cell Tissue Kinet 1974;7:241-50.","journal-title":"Cell Tissue Kinet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1136\/jcp.30.11.1068","article-title":"Technique for microdissection and measurement in biopsies of human small intestine","volume":"30","author":"Ferguson, A.; Sutherland, A.; Macdonald, T.T.; Allan, F.","year":"1977","unstructured":"Ferguson A, Sutherland A, Macdonald TT, Allan F. Technique for microdissection and measurement in biopsies of human small intestine. J Clin Pathol 1977;30: 1068-73.","journal-title":"J Clin Pathol"},{"key":"ref_3","article-title":"Assessment of villus and crypt population sizes in human small intestinal biopsies. Gut 1979; 20: A 921","author":"Wright, N.; Zucoloto, S.; Bramble, M.; Record, C.","unstructured":"Wright N, Zucoloto S, Bramble M, Record C. Assessment of villus and crypt population sizes in human small intestinal biopsies. Gut 1979;20:A 921."},{"key":"ref_4","article-title":"Duodenal mucosal architecture in non-specific and ulcer-associated duodenitis","author":"Hasan, M.; Sircus, W.; Ferguson, A.","unstructured":"Hasan M, Sircus W, Ferguson A. Duodenal mucosal architecture in non-specific and ulcer-associated duodenitis. Gut (in press)."},{"key":"ref_5","article-title":"Reports and Bulletins prepared by the Association of Clinical Biochemists The following reports and bulletins are published by the Association of Clinical Biochemists. They may be obtained from","unstructured":"Reports and Bulletins prepared by the Association of Clinical Biochemists The following reports and bulletins are published by the Association of Clinical Biochemists. They may be obtained from The Publishing Department, British Medical Journal (ACB Technical Bulletins), BMA House, Tavistock Square, London WC1H 9JR. Overseas readers should remit by British Postal or Money Order."},{"key":"ref_6","article-title":"The assessment of thyroid function","volume-title":"FV FLYJNN and 1R HOBBS","year":"1971","unstructured":"The assessment of thyroid function March 1971 FV FLYJNN and 1R HOBBS"},{"key":"ref_7","article-title":"Renal function tests suitable for clinical practice","volume-title":"RWE WATTS 3 Biochemical tests for the assessment of fetoplacental function","author":"FL MITCHELL, N VEALL, and","year":"1972","unstructured":"Renal function tests suitable for clinical practice January 1972 FL MITCHELL, N VEALL, and RWE WATTS 3 Biochemical tests for the assessment of fetoplacental function May 1975 CE WILDE and RE OAKEY 4 Test of exocrine pancreatic function March 1977"},{"key":"ref_8","article-title":"Assay of cholinesterase in clinical chemistry","year":"1979","unstructured":"Assay of cholinesterase in clinical chemistry March 1979 ELSIE SILK, J KING, and MARY WHITIAKER"},{"key":"ref_9","article-title":"Bilirubin standards and the determination of bilirubin by manual and technicon AutoAnalyzer methods January 1971 BARBARA BILLING","unstructured":"Bilirubin standards and the determination of bilirubin by manual and technicon AutoAnalyzer methods January 1971 BARBARA BILLING, RUTH HASLAM, and N WALD"},{"key":"ref_10","article-title":"Interchangeable cells for spectrophotometers and fluorimeters September 1971 ss BROWN and AH GOWENLOCK 24 Simple tests to detect poisons","volume":"25","author":"K.","year":"1972","unstructured":"Interchangeable cells for spectrophotometers and fluorimeters September 1971 ss BROWN and AH GOWENLOCK 24 Simple tests to detect poisons March 1972 BW MEADE et al. 25 Blood gas analysers May 1972 K DIXON 26 Kits for enzyme activity determination September 1972 SB ROSALKI and D TARLOW 27 Assessment of pumps suitable for incorporation into existing continuous flow analytical systems November 1972 A FLECK et al. 28 Routine clinical measurements of transferrin in human serum September 1973 K DIXON","journal-title":"BW MEADE et al; FLECK et al. 28 Routine clinical measurements of transferrin in human serum September; Blood gas analysers"},{"key":"ref_11","article-title":"Control materials for clinical biochemistry","volume-title":"JF STEVENS","year":"1973","unstructured":"Control materials for clinical biochemistry (5th edition) September 1973 JF STEVENS","edition":"5th edition"},{"key":"ref_12","article-title":"Notes on the quality of performance of serum cholesterol assays September 1973 ss","unstructured":"Notes on the quality of performance of serum cholesterol assays September 1973 ss BROWN"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.34.10.1181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:22:39Z","timestamp":1758914559000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.34.10.1181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,10]]},"references-count":12,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1981,10,1]]},"published-print":{"date-parts":[[1981,10]]}},"alternative-id":["10.1136\/jcp.34.10.1181"],"URL":"https:\/\/doi.org\/10.1136\/jcp.34.10.1181","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,10]]}}}