{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:47:07Z","timestamp":1758808027350,"version":"3.44.0"},"reference-count":6,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1981,3]]},"abstract":"<jats:p>Two groups of four-year survivors with acute lymphoblastic leukaemia (ALL) are compared: an 'old' series consisting of 83 patients diagnosed before 1968, and a 'new' series of 366 patients included in Medial Research Council trials (UKALL I-III) and diagnosed in 1970-4. Both series differed significantly from a group of ALL patients who survived less than four years in having lower total leucocyte and blast-cell counts at diagnosis, but the new series did not show the significant differences in organ involvement and platelet count seen in the old series. In both series, girls were more likely than boys to survive for four years and less likely to have relapsed meanwhile; in the new series, relapse rates were also lower for girls than for boys after four years, and subsequent survival was significantly better. There was no difference between the two series in survival rates of those patients who had relapsed before reaching four years. A much higher proportion of the new series, however, had reached four years without prior relapse, and these had a more favourable subsequent survival than the corresponding group of the old series. About 90% of patients achieving four years' continuous complete remission on these UKALL regimes seem likely to survive for 10 years.<\/jats:p>","DOI":"10.1136\/jcp.34.3.249","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"249-253","source":"Crossref","is-referenced-by-count":7,"title":["Acute lymphoblastic leukaemia: four-year survivals old and new."],"prefix":"10.1136","volume":"34","author":[{"given":"R M","family":"Hardisty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Till","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Peto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,3,1]]},"reference":[{"key":"ref_1","first-page":"534","article-title":"Long survivals in acute leukaemia","volume":"i:","author":"Till, M.M.; Hardisty, R.M.; Pike, M.C.","year":"1973","unstructured":"Till MM, Hardisty RM, Pike MC. Long survivals in acute leukaemia. Lancet 1973;i:534-8.","journal-title":"Lancet"},{"key":"ref_2","first-page":"381","article-title":"Medical Research Council's Working Party on Leukaemia in Childhood. Treatment of acute lymphoblastic leukaemia: effect of 'prophylactic' therapy against central nervous system leukaemia","volume":"ii:","year":"1973","unstructured":"Medical Research Council's Working Party on Leukaemia in Childhood. Treatment of acute lymphoblastic leukaemia: effect of 'prophylactic' therapy against central nervous system leukaemia. Br Med J 1973;ii: 381-4.","journal-title":"Br Med J"},{"key":"ref_3","first-page":"\"179","article-title":"Timing and the toxicity of combined 6-mercaptopurine and methotrexate maintenance therapy","volume":"33","author":"Br Med J Br Med J","year":"1976","unstructured":"Timing and the toxicity of combined 6-mercaptopurine and methotrexate maintenance therapy. Br J Haem 1976;33:179-88. 4Medical Research Council's Working Party on Leukaemia in Childhood. Treatment of acute lymphoblastic leukaemia; effect of variation in length of treatment on duration of remission. Br Med J 1977;2:495-7. Medical Research Council's Working Party on Leukaemia in Childhood. Effects of varying radiation schedule, cyclophosphamide treatment, and duration of treatment in acute lymphoblastic leukaemia. Br Med J 1978;2: 787-91.","journal-title":"Br J Haem; Research Council's Working Party on Leukaemia in Childhood. Treatment of acute lymphoblastic leukaemia; effect of variation in length of treatment on duration of remission"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/bjc.1977.240","article-title":"Medical Research Council's Working Party on Leukaemia in Childhood. Analysis of treatment in childhood leukaemia. V. Advantage of reduced chemotherapy during and immediately after cranial irradiation","volume":"36","year":"1977","unstructured":"Medical Research Council's Working Party on Leukaemia in Childhood. Analysis of treatment in childhood leukaemia. V. Advantage of reduced chemotherapy during and immediately after cranial irradiation. Br J Cancer 1977;36:625-33.","journal-title":"Br J Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","article-title":"Design and analysis of randomised clinical trials requiring prolonged observation of each patient","volume":"35","author":"Peto, R.; Pike, M.C.; Armitage, P.","year":"1977","unstructured":"Peto R, Pike MC, Armitage P, et al. Design and analysis of randomised clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 1977;35:1-39.","journal-title":"II. Analysis and examples. Br J Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/1097-0142(196804)21:4<595::AID-CNCR2820210408>3.0.CO;2-4","article-title":"Long-term survivors in acute leukemia and Burkitt's tumor","volume":"21","author":"Burchenal, J.H.","year":"1968","unstructured":"Burchenal JH. Long-term survivors in acute leukemia and Burkitt's tumor. Cancer 1968;21:595-9.","journal-title":"Cancer"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.34.3.249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:12:54Z","timestamp":1758805974000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.34.3.249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1981,3,1]]},"published-print":{"date-parts":[[1981,3]]}},"alternative-id":["10.1136\/jcp.34.3.249"],"URL":"https:\/\/doi.org\/10.1136\/jcp.34.3.249","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1981,3]]}}}