{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:49:31Z","timestamp":1775065771491,"version":"3.50.1"},"reference-count":35,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1981,3]]},"abstract":"<jats:p>Indirect immunofluorescence studies of blood group A, H, I, and i antigens were performed on the gastric mucosae and tumor tissues of patients with gastric carcinoma, on the mucosae of patients with chronic benign gastric ulceration, and on the mucosae of infants who had died of causes other than gastrointestinal disease. The following findings were of particular interest: (1) Normal 'secretor' type mucosae were distinguishable from 'non-secretor' type mucosae by the uniform staining of the A or H antigens at the surface and in the pits. Normal 'non-secretor' type mucosae showed little staining of the H or A antigens but, instead, there was staining with anti-I(Ma) antibody. Staining with anti-I(Step) and anti-i(Den) did not show a clear correlation with the 'secretor'\/'non-secretor' status of the normal mucosae. (2) Apparently normal areas of gastric mucosae of patients with gastric carcinoma or the normal part of gastric mucosae of patients with benign gastric ulcer frequently showed focal areas of loss or gain of the blood group antigens as is often seen in gastric carcinoma tissues. (3) In the mucosae of patients with intestinal metaplasia there was marked loss of A\/H antigens in 'secretors' and I(Ma) antigen in 'non-secretors'. (4) Staining characteristics of tissues from gastric carcinoma were:(a) Focal loss of the expected A\/H or I antigens was observed with much variation in staining from area to area, but only a minority showed complete loss of the expected staining. (b) A majority of the carcinomas from 'secretors' showed foci of substantial staining with anti-I(Ma) in contrast to normal 'secretor' mucosae. This is probably due to incomplete biosynthesis of A\/H determinants. (c) Incompatible A-like staining by a rabbit anti-A serum was observed in one out of nine adenocarcinomas from blood group B or O persons. (d) A few cases showed substantial i antigen staining. The aberrant expression of blood group A, H, I, and i antigens in neoplastic as well as in some areas of morphologically normal mucosa of patients with benign and malignant diseases of the stomach is discussed in the context of current biochemical knowledge.<\/jats:p>","DOI":"10.1136\/jcp.34.3.320","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"320-337","source":"Crossref","is-referenced-by-count":59,"title":["Immunocytochemical studies of blood group A, H, I, and i antigens in gastric mucosae of infants with normal gastric histology and of patients with gastric carcinoma and chronic benign peptic ulceration."],"prefix":"10.1136","volume":"34","author":[{"given":"A","family":"Kapadia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Feizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Keeling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Slavin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/S0021-9258(18)50747-X","article-title":"Characterization of a blood group I-active ganglioside. 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Acta Path Scand 1963;59:447-55.","journal-title":"Acta Path Scand"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1620\/tjem.51.297","article-title":"Polysaccharides and a glycidamin in the tissue of gastric cancer","volume":"51","author":"Oh-Uti, K.","year":"1949","unstructured":"Oh-Uti K. Polysaccharides and a glycidamin in the tissue of gastric cancer. Tohoku J Exp Med 1949;51: 297-304.","journal-title":"Tohoku J Exp Med"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1620\/tjem.68.119","article-title":"Molisch-positive mucopolysaccharides of gastric cancers as compared with the corresponding components of gastric mucosae","volume":"68","author":"Kawasaki, H.","year":"1958","unstructured":"Kawasaki H. Molisch-positive mucopolysaccharides of gastric cancers as compared with the corresponding components of gastric mucosae. 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