{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:40:01Z","timestamp":1758915601223,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:p>IgM rheumatoid factors have been measured in 92 patients by both laser nephelometry and the traditional hospital procedure of a latex slide test followed by differential agglutination titre (DAT). Of the results 86% were in accordance by both methods, but seronegative patients with a high nephelometry score all showed, after reference to their clinical state and previous investigations, that the nephelometry result more accurately represented their clinical state than the DAT, which was shown to be in error in five out of the six cases. Six seropositive patients with low nephelometry scores were also studied; three were in complete remission on gold or penicillamine therapy. Nephelometry is both technically simpler and more reliable than the traditional DAT method, and our results suggest that it has some advantages over the DAT in routine use.<\/jats:p>","DOI":"10.1136\/jcp.34.4.396","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"396-399","source":"Crossref","is-referenced-by-count":6,"title":["Nephelometry v differential agglutination titre in the measurement of rheumatoid factors."],"prefix":"10.1136","volume":"34","author":[{"given":"M H","family":"Pritchard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Jobbins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1699-0463.1940.tb01475.x","article-title":"Occurrence of factors in human serum activating specific agglutination of sheep blood corpuscles","volume":"17","author":"Waaler, E.","year":"1940","unstructured":"Waaler E. Occurrence of factors in human serum activating specific agglutination of sheep blood corpuscles. Acta Path et Microbiol Scand 1940;17:172-88.","journal-title":"Acta Path et Microbiol Scand"},{"key":"ref_2","first-page":"1","article-title":"Differential agglutination of normal and sensitised sheep erythrocytes by sera of patients","volume-title":"with rheumatoid arthritis. Proc Soc Exp Biol Med","volume":"68","author":"Rose, H.M.; Ragan, C.; Pearce, E.; Lipman, M.O.","year":"1948","unstructured":"Rose HM, Ragan C, Pearce E, Lipman MO. Differential agglutination of normal and sensitised sheep erythrocytes by sera of patients with rheumatoid arthritis. Proc Soc Exp Biol Med 1948;68:1-6."},{"key":"ref_3","first-page":"289","article-title":"FIT haemagglutination test for serum antigammaglobulin in arthritides sero-positive and seronegative by other tests","volume":"28","author":"Zutshi, D.W.; Reading, C.A.; Epstein, W.V.; Ansell, B.M.; Holborow, W.","year":"1969","unstructured":"Zutshi DW, Reading CA, Epstein WV, Ansell BM, Holborow W. FIT haemagglutination test for serum antigammaglobulin in arthritides sero-positive and seronegative by other tests. Ann Rheum Dis 1969;28:289-99."},{"issue":"9","key":"ref_4","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1093\/clinchem\/22.9.1465","article-title":"Use of laser nephelometry in the measurement of serum proteins","volume":"22","author":"Deaton, C.D.; Maxwell, K.W.; Smith, R.S.; Reveling, R.L.","year":"1976","unstructured":"Deaton CD, Maxwell KW, Smith RS, Reveling RL. Use of laser nephelometry in the measurement of serum proteins. Clin Chem 1976;22\/9:1465-71.","journal-title":"Clin Chem"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1093\/clinchem\/25.11.1909","article-title":"Rate nephelometric measurement of rheumatoid factor in serum","volume":"25","author":"Finley, P.R.; Hicks, J.; Williams, R.J.; Hinlicky, J.; Lichti, D.A.","year":"1979","unstructured":"Finley PR, Hicks J, Williams RJ, Hinlicky J, Lichti DA. Rate nephelometric measurement of rheumatoid factor in serum. Clin Chem 1979;25:1909-14.","journal-title":"Clin Chem"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/ard.37.6.493","article-title":"Gold and penicillamine: a proposed mode of action in rheumatoid arthritis based on synovial fluid analysis","volume":"37","author":"Pritchard, M.H.; Nuki, G.","year":"1978","unstructured":"Pritchard MH, Nuki G. Gold and penicillamine: a proposed mode of action in rheumatoid arthritis based on synovial fluid analysis. Ann Rheum Dis 1978;37:493-503.","journal-title":"Ann Rheum Dis"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/bmj.1.5121.523","article-title":"Clinical significance of the rheumatoid serum factor","volume":"i:","author":"Kellgren, J.H.; Ball, J.","year":"1959","unstructured":"Kellgren JH, Ball J. Clinical significance of the rheumatoid serum factor. Br MedJ 1959;i:523-31.","journal-title":"Br MedJ"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/ard.20.3.235","article-title":"Epidemiology of the sheep cell agglutination test","volume":"20","author":"Ball, J.; Lawrence, J.S.","year":"1961","unstructured":"Ball J, Lawrence JS. Epidemiology of the sheep cell agglutination test. Ann Rheurm Dis 1961;20:235-43.","journal-title":"Ann Rheurm Dis"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.34.4.396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:04:06Z","timestamp":1758913446000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.34.4.396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1981,4,1]]},"published-print":{"date-parts":[[1981,4]]}},"alternative-id":["10.1136\/jcp.34.4.396"],"URL":"https:\/\/doi.org\/10.1136\/jcp.34.4.396","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1981,4]]}}}