{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:43:32Z","timestamp":1765082612946,"version":"3.46.0"},"reference-count":15,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1981,5]]},"abstract":"<jats:p>As part of a wider survey of infections and defence mechanisms, concentrations of serum immunoglobulins IgG, IgA, and IgM were measured regularly by single radial immunodiffusion in a group of children receiving treatment for acute lymphoblastic leukaemia while in their first remission. IgM concentrations were often markedly raised at diagnosis, and IgG and IgA concentrations both began falling within one month of diagnosis. Four months after diagnosis all three had fallen significantly, but this tendency stopped after six months. Only IgG partially recovered, and non returned to pretreatment concentrations even in children followed for two years. The results suggest that vincristine and prednisone are the major factors that initiated the fall in IgG and IgA. Lowered IgM concentrations may have been due to cranial irradiation or continuous maintenance treatment, or both.<\/jats:p>","DOI":"10.1136\/jcp.34.5.479","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"479-482","source":"Crossref","is-referenced-by-count":10,"title":["Immunoglobulin concentrations in children receiving treatment for acute lymphoblastic leukaemia."],"prefix":"10.1136","volume":"34","author":[{"given":"M M","family":"Reid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A W","family":"Craft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/adc.52.3.245","article-title":"Serial studies of numbers of circulating T and B lymphocytes in children with acute lymphoblastic leukaemia","volume":"52","author":"Reid, M.M.; Craft, A.W.; Todd, J.A.","year":"1977","unstructured":"Reid MM, Craft AW, Todd JA. 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Immunological rebound after cessation of longterm chemotherapy in acute lymphoblastic leukaemia: changes in T and B cell populations in bone marrow and in peripheral blood. Br J Haematol 1974; 27:477-87.","journal-title":"Br J Haematol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2141.1976.tb03529.x","article-title":"Analysis of treatment in childhood leukaemia II. Timing and toxicity of combined 6-mercaptopurine and methotrexate maintenance therapy","volume":"33","author":"MacLennan, I.C.M.; Kay, H.E.M.; Festenstein, M.; Smith, P.S.","year":"1976","unstructured":"MacLennan ICM, Kay HEM, Festenstein M, Smith PS. Analysis of treatment in childhood leukaemia II. Timing and toxicity of combined 6-mercaptopurine and methotrexate maintenance therapy. 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