{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:54:31Z","timestamp":1765727671540,"version":"3.48.0"},"reference-count":15,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1981,8]]},"abstract":"<jats:p>Reflux oesophagitis may be accompanied by replacement of squamous epithelium by columnar epithelium (Barrett's oesophagus). The columnar epithelium may resemble either gastric or intestinal mucosa, though ultrastructural and histochemical studies indicate that the intestinal type does not necessarily resemble normal small intestine. Twenty-two malignant and 10 benign oesophageal specimens were examined histologically and by mucin histochemistry in an attempt to classify the various types of columnar epithelium. An incompletely differentiated variant of intestinal metaplasia secreting sulphomucins was associated with well but not poorly differentiated adenocarcinomas (p less than 0.02; Fisher's exact test). Similar findings have been described in the stomach and incomplete intestinal metaplasia may be related to disorders of growth and differentiation described in other sites such as the colon. These observations may help in the interpretation of oesophageal biopsies, possibly permitting identification of patients at risk of developing oesophageal adenocarcinoma.<\/jats:p>","DOI":"10.1136\/jcp.34.8.866","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"866-870","source":"Crossref","is-referenced-by-count":76,"title":["Mucin histochemistry of the columnar epithelium of the oesophagus: a retrospective study."],"prefix":"10.1136","volume":"34","author":[{"given":"J R","family":"Jass","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,8,1]]},"reference":[{"key":"ref_1","article-title":"Gastrointestinal pathology","author":"Morson, B.C.; Dawson, I.M.P.","year":"1979","unstructured":"Morson BC, Dawson IMP. Gastrointestinal pathology 2nd ed. Oxford: Blackwell Scientific Publications, 1979.","edition":"2nd ed"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0016-5085(70)80058-0","article-title":"Morphology of the epithelium of the distal esophagus in patients with midesophageal peptic strictures","volume":"58","author":"Trier, J.S.","year":"1970","unstructured":"Trier JS. Morphology of the epithelium of the distal esophagus in patients with midesophageal peptic strictures. Gastroenterology 1970;58:444-61.","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/BF01076212","article-title":"Enzyme and ultrastructural characteristics of esophageal columnar epithelium","volume":"19","author":"Berensen, M.M.; Herbst, J.J.; Freston, J.W.","year":"1974","unstructured":"Berensen MM, Herbst JJ, Freston JW. Enzyme and ultrastructural characteristics of esophageal columnar epithelium. American Journal of Digestive Diseases 1974;19:.895-z7.","journal-title":"American Journal of Digestive Diseases"},{"key":"ref_4","first-page":"\"Laur6n\" # \"31","article-title":"Columnar mucosa of the distal oesophagus in patients with gastroesophageal reflux","volume":"64","author":"Ozzello, L.; Savary, M.; Roethlisberger, B.","year":"1977","unstructured":"Ozzello L, Savary M, Roethlisberger B. Columnar mucosa of the distal oesophagus in patients with gastroesophageal reflux. In: Sommers SC, Rosen PP, eds. Pathology annual Vol 12. New York: Appleton-Century-Crofts, 1977:41-86. Laur6n P. The two main types of gastric carcinoma; diffuse and so-called intestinal type carcinomas. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965;64:31-49.","journal-title":"Pathology annual Vol 12; Acta Pathol Microbiol Scand; The two main types of gastric carcinoma; diffuse and so-called intestinal type carcinomas. An attempt at a histo-clinical classification"},{"key":"ref_5","first-page":"251","article-title":"Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances","volume":"59","author":"Nakamura, K.; Sugano, H.; Takagi, K.","year":"1968","unstructured":"Nakamura K, Sugano H, Takagi K. Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. Gann 1968;59:251-8.","journal-title":"Gann"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/jcp.33.9.801","article-title":"Role of intestinal metaplasia in the histogenesis of gastric carcinoma","volume":"33","author":"Jass, JR","year":"1980","unstructured":"Jass JR. Role of intestinal metaplasia in the histogenesis of gastric carcinoma. J Clin Pathol 1980;33:801-10.","journal-title":"J Clin Pathol"},{"key":"ref_7","first-page":"401","article-title":"Alcian-blue techniques for the histochemical study of acidic carbohydrates","volume":"4","author":"Mowry, W.","year":"1956","unstructured":"Mowry W. Alcian-blue techniques for the histochemical study of acidic carbohydrates. J Histochem Cytochem 1956;4:401.","journal-title":"J Histochem Cytochem"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1177\/13.3.211","article-title":"Diamine methods for differentiating mucosubstances histochemically","volume":"13","author":"Spicer, S.S.","year":"1965","unstructured":"Spicer SS. Diamine methods for differentiating mucosubstances histochemically. J Histochem Cytochem 1965; 13:211-34.","journal-title":"J Histochem Cytochem"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/1097-0142(196709)20:9<1418::AID-CNCR2820200908>3.0.CO;2-Z","article-title":"Intestinal metaplasia and histogenesis of carcinoma of the human stomach","volume":"20","author":"Ming, S.C.; Goldman, H.; Freiman, D.G.","year":"1967","unstructured":"Ming SC, Goldman H, Freiman DG. Intestinal metaplasia and histogenesis of carcinoma of the human stomach. Cancer 1967;20:1418-29.","journal-title":"Cancer"},{"key":"ref_10","first-page":"24958","article-title":"Loss of differentiation in intestinal metaplasia in cancerous stomachs. A comparative morphologic study","volume":"164","author":"Heilmann, K.L.; Hopker, W.W.","year":"1979","unstructured":"Heilmann KL, Hopker WW. Loss of differentiation in intestinal metaplasia in cancerous stomachs. A comparative morphologic study. Pathol Res Pract 1979;164:24958.","journal-title":"Pathol Res Pract"},{"key":"ref_11","first-page":"231","article-title":"Distribution of marker enzymes and mucin in intestinal metaplasia in human stomachs and relation ofcomplete and incomplete types of intestinal metaplasia to minute gastric carcinomas","volume":"65","author":"Matsukura, N.; Suzuki, K.; Kawachi, T.","year":"1980","unstructured":"Matsukura N, Suzuki K, Kawachi T, et al. Distribution of marker enzymes and mucin in intestinal metaplasia in human stomachs and relation ofcomplete and incomplete types of intestinal metaplasia to minute gastric carcinomas. Journal of the National Cancer Institute 1980;65: 231-40.","journal-title":"Journal of the National Cancer Institute"},{"key":"ref_12","article-title":"Intestinal metaplasia with colonictype sulphomucins in the gastric mucosa; its association with gastric carcinoma","author":"Sipponen, P.; Seppala, K.; Varis, K.; Hjelt, L.; Ihamaki, T.; Kekki, M.; Siurala, M.","year":"1981","unstructured":"Sipponen P, Seppala K, Varis K, Hjelt L, Ihamaki T, Kekki M, Siurala M. Intestinal metaplasia with colonictype sulphomucins in the gastric mucosa; its association with gastric carcinoma. Acta Pathol Microbiol Scand 1981;(in press).","journal-title":"Acta Pathol Microbiol Scand"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/aja.1001240303","article-title":"Origin and renewal of goblet cells in the epithelium of the mouse small intestine","volume":"124","author":"Merzel, J.; Leblond, C.P.","year":"1969","unstructured":"Merzel J, Leblond CP. Origin and renewal of goblet cells in the epithelium of the mouse small intestine. Am J Anat 1969;124:281-306.","journal-title":"Am J Anat"},{"key":"ref_14","first-page":"926","article-title":"Comparative electron microscopic features of normal, hyperplastic and adenomatous","volume-title":"human colonic epithelium. Gastroenterology 1973; 64","author":"Kaye, G.I.; Fenoglio, C.M.; Pascal, P.R.; Lane, N.","unstructured":"Kaye GI, Fenoglio CM, Pascal PR, Lane N. Comparative electron microscopic features of normal, hyperplastic and adenomatous human colonic epithelium. Gastroenterology 1973;64:926-45."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1002\/1097-0142(197605)37:5<2388::AID-CNCR2820370531>3.0.CO;2-9","article-title":"An ultrastructural and histochemical study of mucin changes in the colonic mucosa adjacent to and remote from carcinoma","volume":"37","author":"Dawson, P.A.; Filipe, M.I.","year":"1976","unstructured":"Dawson PA, Filipe MI. An ultrastructural and histochemical study of mucin changes in the colonic mucosa adjacent to and remote from carcinoma. Cancer 1976; 37:2388-98.","journal-title":"Cancer"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.34.8.866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:00:06Z","timestamp":1765598406000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.34.8.866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,8]]},"references-count":15,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1981,8,1]]},"published-print":{"date-parts":[[1981,8]]}},"alternative-id":["10.1136\/jcp.34.8.866"],"URL":"https:\/\/doi.org\/10.1136\/jcp.34.8.866","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1981,8]]}}}