{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:17:43Z","timestamp":1758845863696,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:p>To assess the exocrine pancreatic function in beta-thalassemia major with iron overload, serum immunoreactive trypsin (IRT) was measured in 38 patients with this condition. In 23 (60%) patients' IRT was abnormal: it was subnormal in 16 patients and supranormal in seven. Whereas subnormal IRT concentrations were more frequent in patients of more than 12 years old, supranormal IRT concentrations were more frequent in younger patients. These data provide the first antemortem evidence of exocrine pancreatic damage in this condition. They also suggest that this acinar cell damage is initially associated with a rise in IRT which is followed by a fall in the serum concentration of this enzyme.<\/jats:p>","DOI":"10.1136\/jcp.34.9.970","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"970-971","source":"Crossref","is-referenced-by-count":17,"title":["Serum immunoreactive trypsin in beta-thalassaemia major."],"prefix":"10.1136","volume":"34","author":[{"given":"M","family":"Hussain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Dandona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Fedail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Ramdial","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A V","family":"Hoffbrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,9,1]]},"reference":[{"key":"ref_1","first-page":"230","article-title":"The majority with abnormal IRT (22 of 26, 86%) had low concentrations while four (14%) had raised IRT concentrations. Whereas low IRT concentrations reflect a significantly diminished exocrine pancreatic reserve,2 3 the significance of raised IRT in serum is not clear. It has, however, been shown that in at least one other condition with chronic damage of exocrine pancreatic acinar tissue-cystic fibrosis-serum IRT can be raised without clinical evidence of acute pancreatitis.4 It is possible that Modell","volume-title":"metabolism and its disorders","author":"I.R.T.","year":"1975","unstructured":"IRT. The majority with abnormal IRT (22 of 26, 86%) had low concentrations while four (14%) had raised IRT concentrations. Whereas low IRT concentrations reflect a significantly diminished exocrine pancreatic reserve,2 3 the significance of raised IRT in serum is not clear. It has, however, been shown that in at least one other condition with chronic damage of exocrine pancreatic acinar tissue-cystic fibrosis-serum IRT can be raised without clinical evidence of acute pancreatitis.4 It is possible that Modell B. Transfusional haemochromatosis. In: King H, ed. Iron metabolism and its disorders. New York: Elsevier Publishing Co, 1975:230."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0140-6736(77)90066-6","article-title":"Diagnostic importance of changes in circulating concentrations of immunoreactive trypsin","volume":"ii:","author":"Elias, E.; Redshaw, M.; Wood, T.","year":"1977","unstructured":"Elias E, Redshaw M, Wood T. Diagnostic importance of changes in circulating concentrations of immunoreactive trypsin. Lancet 1977;ii:66-8.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1136\/bmj.2.6145.1125","article-title":"Serum trypsin concentrations in diabetes mellitis","volume":"ii:","author":"Dandona, P.; Elias, E.; Beckett, A.G.","year":"1978","unstructured":"Dandona P, Elias E, Beckett AG. Serum trypsin concentrations in diabetes mellitis. Br MedJ 1978;ii:1125-6.","journal-title":"Br MedJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/thx.36.1.60","article-title":"Serum immunoreactive trypsin in cystic fibrosis","volume":"36","author":"Dandona, P.; Hodson, M.E.; Bell, J.; Ramdial, L.; Beldon, I.; Batten, J.C.","year":"1981","unstructured":"Dandona P, Hodson ME, Bell J, Ramdial L, Beldon I, Batten JC. Serum immunoreactive trypsin in cystic fibrosis. Thorax 1981;36:60-2.","journal-title":"Thorax"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0140-6736(79)91721-5","article-title":"Improvement in iron status and liver function with chronic subcutaneous desferrioxamine-therapy","volume":"i:","author":"Hoffbrand, A.V.; Gorman, A.; Laulicht, M.","year":"1979","unstructured":"Hoffbrand AV, Gorman A, Laulicht M, et al. Improvement in iron status and liver function with chronic subcutaneous desferrioxamine-therapy. Lancet 1979;i:947-9.","journal-title":"Lancet"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.34.9.970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:23:56Z","timestamp":1758803036000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.34.9.970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9]]},"references-count":5,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1981,9,1]]},"published-print":{"date-parts":[[1981,9]]}},"alternative-id":["10.1136\/jcp.34.9.970"],"URL":"https:\/\/doi.org\/10.1136\/jcp.34.9.970","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1981,9]]}}}