{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:28:30Z","timestamp":1765726110358,"version":"3.48.0"},"reference-count":8,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1982,12]]},"abstract":"<jats:p>Pregnancies at risk of being associated with (open) neural tube defects can be identified by maternal serum and amniotic-fluid alphafetoprotein (AFP) concentrations in excess of established screening cut-off valves in conjunction with the results of an amniotic fluid electrophoretic acetylcholinesterase screening test. The risk associated with the AFP cut-off values are formulated in terms of a population screening programme. These \"population risks\" are of little value in the assessment of test results from individual \"at-risk\" pregnancies, especially when the observed AFP concentrations are in proximity to the \"cut-off\" values. A complete risk assessment procedure for individual pregnancies is described and presented in graphical form to permit immediate access by clinical staff.<\/jats:p>","DOI":"10.1136\/jcp.35.12.1334","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1334-1339","source":"Crossref","is-referenced-by-count":2,"title":["Neural-tube defect risk assessment for individual pregnancies using alphafetoprotein and acetylcholinesterase test results."],"prefix":"10.1136","volume":"35","author":[{"given":"P W","family":"Strike","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,12,1]]},"reference":[{"key":"ref_1","first-page":"1323","article-title":"Report of the UK collaborative study on alphafetoprotein in relation to neural tube defects","volume":"i:","year":"1977","unstructured":"Report of the UK collaborative study on alphafetoprotein in relation to neural tube defects. 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Bristol: J Wright & Sons Ltd 1981:66-72."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.35.12.1334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:23:46Z","timestamp":1765725826000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.35.12.1334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12]]},"references-count":8,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1982,12,1]]},"published-print":{"date-parts":[[1982,12]]}},"alternative-id":["10.1136\/jcp.35.12.1334"],"URL":"https:\/\/doi.org\/10.1136\/jcp.35.12.1334","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1982,12]]}}}