{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:28:11Z","timestamp":1771867691729,"version":"3.50.1"},"reference-count":34,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1982,5]]},"abstract":"<jats:p>It has been established that considerable blast-transformation and mitotic activity occurs among epithelial lymphocytes of untreated coeliac mucosa. This paper is concerned solely with the proliferative activity of epithelial lymphocytes (expressed as percentage \"mitotic index\") in the prospective diagnosis of coeliac disease, in comparison with other conditions such as lymphoma. Crohn's disease and immunodeficiency which are often associated with malabsorption and flattening of jejunal mucosa. The results demonstrate that a high mitotic index (greater than 0.2%) clearly distinguishes, and hence predicts, gluten-associated enteropathies (including dermatitis herpetiformis and malignant histiocytosis) from others in which gluten plays no aetiological role and where the mitotic index differs insignificantly from normal control mucosae (much less than 0.2%). Furthermore, it has been demonstrated that the mitotic index is raised in so-called \"non-responsive coeliacs,\" thus suggesting that such patients may also be gluten-sensitive despite their subsequent failure to respond morphologically to dietary gluten restriction.<\/jats:p>","DOI":"10.1136\/jcp.35.5.517","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"517-525","source":"Crossref","is-referenced-by-count":27,"title":["Studies of intestinal lymphoid tissue. IV--The predictive value of raised mitotic indices among jejunal epithelial lymphocytes in the diagnosis of gluten-sensitive enteropathy."],"prefix":"10.1136","volume":"35","author":[{"given":"M N","family":"Marsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,5,1]]},"reference":[{"issue":"38","key":"ref_1","first-page":"419","article-title":"Doniach 1. Histopathological studies in steatorrhoea","volume":"1960","author":"Shiner, M.","unstructured":"Shiner M, Doniach 1. Histopathological studies in steatorrhoea. Gastroenterology, 1960;38:419-40.","journal-title":"Gastroenterology"},{"issue":"16","key":"ref_2","first-page":"\"87","article-title":"Studies of intestinal lymphoid tissue. VThe cytology and electron microscopy of gluten-sensitive sibility that such criteria are too restrictive must always be considered.8 Such sentiments are embodied in previous reports of persons in whom a mucosal response initially occurred after gluten restriction, enteropathy, with particular reference to its immunopathology","volume":"1981","author":"Marsh, M.N.","year":"1967","unstructured":"Marsh MN. Studies of intestinal lymphoid tissue. VThe cytology and electron microscopy of gluten-sensitive sibility that such criteria are too restrictive must always be considered.8 Such sentiments are embodied in previous reports of persons in whom a mucosal response initially occurred after gluten restriction, enteropathy, with particular reference to its immunopathology. Scand J Gastroenterol 1981;16, suppl 70: 87-106. Pink 1, Creamer B. Response to a gluten-free diet of patients with coeliac syndrome. Lancet 1967;i:300-4.","journal-title":"Scand J Gastroenterol; Creamer B. Response to a gluten-free diet of patients with coeliac syndrome"},{"key":"ref_3","first-page":"678","article-title":"A case of adult coeliac disease resistant to treatment","volume":"ii:","author":"Neale, G.","year":"1968","unstructured":"Neale G. A case of adult coeliac disease resistant to treatment. Br Med J 1968;ii:678-84.","journal-title":"Br Med J"},{"issue":"3","key":"ref_4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/gut.3.3.232","article-title":"Read AE, Naish J. Intestinal reticulosis as a complication of steatorrhoea","volume":"1962","author":"Gough, K.R.","unstructured":"Gough KR, Read AE, Naish J. Intestinal reticulosis as a complication of steatorrhoea. Gut 1962;3:232-9.","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF02233180","article-title":"Steatorrhoea and malignant lymphoma. The relationship of tumours of lymphoid tissue and coeliac","volume":"12","author":"Austad, W.; Cornes, J.S.; Gough, K.R.","year":"1967","unstructured":"Austad W, Cornes JS, Gough KR, et al. Steatorrhoea and malignant lymphoma. The relationship of tumours of lymphoid tissue and coeliac disease, Am J Dig Dis 1967; 12:475-90.","journal-title":"disease, Am J Dig Dis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00005792-196603000-00002","article-title":"Abdominal lymphoma presenting as malabsorption","volume":"45","author":"Eidelman, S.; Parkins, R.A.; Rubin, C.E.","year":"1966","unstructured":"Eidelman S, Parkins RA, Rubin CE. Abdominal lymphoma presenting as malabsorption. Medicine 1966;45: 111-37.","journal-title":"Medicine"},{"key":"ref_7","first-page":"521","article-title":"Abdominal lymphoma presenting as malabsorption","volume":"40","author":"Novis, B.; Bank, S.; Marks, I.","year":"1971","unstructured":"Novis B, Bank S, Marks I. 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Lancaster: MTP, 1978."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0002-9343(67)90252-5","article-title":"Adult hypogammaglobulinaemia with malabsorption and iron deficiency anaemia","volume":"43","author":"Johnson, R.L.; van Arsdel, P.; Tobe, A.","year":"1967","unstructured":"Johnson RL, van Arsdel P, Tobe A, et al. Adult hypogammaglobulinaemia with malabsorption and iron deficiency anaemia. Am J Med 1967;43:935-43.","journal-title":"Am J Med"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0016-5085(19)34234-9","article-title":"Clinical giardiasis and intestinal malabsorption","volume":"53","author":"Hoskins, L.C.; Winawer, S.J.; Broitman, S.A.","year":"1967","unstructured":"Hoskins LC, Winawer SJ, Broitman SA, et al. Clinical giardiasis and intestinal malabsorption. 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Clin Gastroenterol 1974;3:3-10."},{"key":"ref_30","article-title":"The inheritance of coeliac disease","author":"McCrae, W.M.","year":"1970","unstructured":"McCrae WM. The inheritance of coeliac disease. In: Booth CC, Dowling RH, eds. Coeliac disease. London: Churchill-Livingstone, 1970."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0016-5085(72)80173-2","article-title":"Soy protein-another cause of the flat intestinal lesion","volume":"62","author":"Ament, M.E.; Rubin, C.E.","year":"1972","unstructured":"Ament ME, Rubin CE. Soy protein-another cause of the flat intestinal lesion. Gastroenterology 1972;62: 227-34.","journal-title":"Gastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.7326\/0003-4819-89-4-505","article-title":"Refractory sprue: recovery after removal of non-gluten dietary proteins","volume":"89","author":"Baker, A.L.; Rosenberg, I.H.","year":"1978","unstructured":"Baker AL, Rosenberg IH. 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