{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:12:35Z","timestamp":1790212355371,"version":"4.1.0"},"reference-count":20,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1982,8]]},"abstract":"<jats:p>Serum lysozyme activities and semiquantitative analysis of tissue lysozyme distribution were studied in patients with primary biliary cirrhosis (PBC), chronic hepatitis (CH), miscellaneous liver diseases, and normal subjects. Serum lysozyme was significantly raised in PBC and CH. Portal venous blood has similar lysozyme activities to peripheral venous blood in a group of various liver diseases. Lysozyme-containing intralobular cells were decreased in all liver diseases studied but portal tract lysozyme was increased only in PBC and CH. Thus the increase in serum lysozyme in PBC and CH appears to originate from the portal inflammatory infiltrate, seen in these diseases.<\/jats:p>","DOI":"10.1136\/jcp.35.8.815","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"815-819","source":"Crossref","is-referenced-by-count":18,"title":["Lysozyme in chronic liver disease: a biochemical and histological study."],"prefix":"10.1136","volume":"35","author":[{"given":"I H","family":"Manifold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F M","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Cloke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D R","family":"Triger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Underwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1982,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1056\/NEJM197311152892007","article-title":"Usefulness of serum lysozyme measurement in diagnosis and evaluation of sarcoidosis","volume":"289","author":"Pascual, R.S.; Gee, J.B.L.; Finch, S.C.","year":"1973","unstructured":"Pascual RS, Gee JBL, Finch SC. Usefulness of serum lysozyme measurement in diagnosis and evaluation of sarcoidosis. N EnglJ Med 1973;289:1074-6.","journal-title":"N EnglJ Med"},{"key":"ref_2","first-page":"632","article-title":"Plasma levels and the release of a lysozyme-like enzyme from tuberculin-exposed leukocytes of tuberculous and non-tuberculous human beings","volume":"41","author":"Kerby, G.P.; Chaudhuri, S.N.","year":"1953","unstructured":"Kerby GP, Chaudhuri SN. Plasma levels and the release of a lysozyme-like enzyme from tuberculin-exposed leukocytes of tuberculous and non-tuberculous human beings. J Lab Clin Med 1953;41:632-6.","journal-title":"J Lab Clin Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00000441-197304000-00005","article-title":"Serum lysozyme in pulmonary tuberculosis","volume":"265","author":"Perillie, P.E.; Khan, K.; Finch, S.C.","year":"1973","unstructured":"Perillie PE, Khan K, Finch SC. Serum lysozyme in pulmonary tuberculosis. Am J Med Sci 1973;265:297-302.","journal-title":"Am J Med Sci"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJM197502202920805","article-title":"Serum lysozyme in Crohn's disease and ulcerative colitis","volume":"292","author":"Falchuk, K.R.; Perrotto, J.L.; Isselbacher, K.J.","year":"1975","unstructured":"Falchuk KR, Perrotto JL, Isselbacher KJ. Serum lysozyme in Crohn's disease and ulcerative colitis. N Engl J Med 1975;292:395-7.","journal-title":"N Engl J Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1172\/JCI102655","article-title":"The role of the granulocyte as a source of lysozyme in ulcerative colitis","volume":"31","author":"Hiatt, R.B.; Engle, C.; Flood, C.; Karush, A.","year":"1952","unstructured":"Hiatt RB, Engle C, Flood C, Karush A. The role of the granulocyte as a source of lysozyme in ulcerative colitis. J Clin Invest 1952;31:721-6.","journal-title":"J Clin Invest"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/BF01076199","article-title":"Lysozyme in Crohn's disease and ulcerative colitis","volume":"22","author":"Pruzanski, W.; Marcon, N.; Ottaway, C.; Prokipchuk, E.","year":"1977","unstructured":"Pruzanski W, Marcon N, Ottaway C, Prokipchuk E. Lysozyme in Crohn's disease and ulcerative colitis. Am J Dig Dis 1977;22:995-8.","journal-title":"Am J Dig Dis"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/gut.19.3.233","article-title":"Serum and faecal lysozyme in inflammatory bowel disease","volume":"19","author":"Klass, H.J.; Neale, G.","year":"1978","unstructured":"Klass HJ, Neale G. Serum and faecal lysozyme in inflammatory bowel disease. Gut 1978;19:233-9.","journal-title":"Gut"},{"key":"ref_8","first-page":"297301","article-title":"Serum lysozyme, serum proteins and immunoglobulin determinations in non specific inflammatory bowel disease","volume":"23","author":"true","year":"1978","unstructured":"El-Khatib OS, Lebwohl 0, Attia AA, et al. Serum lysozyme, serum proteins and immunoglobulin determinations in non specific inflammatory bowel disease. Dig Dis 1978;23:297301.","journal-title":"Dig Dis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/jcp.28.2.124","article-title":"The distribution of muramidase (lysozyme) in human tissue","volume":"28","author":"Mason, D.Y.; Taylor, C.R.","year":"1975","unstructured":"Mason DY, Taylor CR. The distribution of muramidase (lysozyme) in human tissue. J Clin Pathol 1975;28:124-32.","journal-title":"J Clin Pathol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/22.3.139","article-title":"Localisation of lysozyme in normal rat tissues by an immunoperoxidase method","volume":"22","author":"Klockers, M.; Osserman, E.F.","year":"1974","unstructured":"Klockers M, Osserman EF. Localisation of lysozyme in normal rat tissues by an immunoperoxidase method. J Histochem Cytochem 1974;22: 139-46.","journal-title":"J Histochem Cytochem"},{"key":"ref_11","first-page":"755","article-title":"Clinical significance of the lysozyme in viral hepatitis","volume":"74","author":"Okada, T.","year":"1977","unstructured":"Okada T. Clinical significance of the lysozyme in viral hepatitis. Jpn J Gastroenterol 1977;74:755-64.","journal-title":"Jpn J Gastroenterol"},{"key":"ref_12","first-page":"26","article-title":"Immunological reactions in chronic diseases of the liver","volume":"43","author":"Bondar, Z.A.; Finogenova, L.G.; Zolotinitskaya, R.P.","year":"1971","unstructured":"Bondar ZA, Finogenova LG, Zolotinitskaya RP. Immunological reactions in chronic diseases of the liver. Ter Arkh 1971;43:26-30.","journal-title":"Ter Arkh"},{"key":"ref_13","first-page":"2324","article-title":"Le dosage du lysozyme serique au cours des cirrhoses","volume":"1","author":"Serrou, B.; Dubois, J.B.; Balmes, J.L.; Girard, C.","year":"1972","unstructured":"Serrou B, Dubois JB, Balmes JL, Girard C. Le dosage du lysozyme serique au cours des cirrhoses. Nouv Presse Med 1972;1:2324.","journal-title":"Nouv Presse Med"},{"key":"ref_14","article-title":"A study of lysozyme in primary biliary cirrhosis in liver","author":"Bishop, F.M.","year":"1979","unstructured":"Bishop FM. A study of lysozyme in primary biliary cirrhosis in liver. Institute of Medical Laboratory Sciences fellowship project, 1979."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0006-3002(52)90045-0","article-title":"Measurement of lysozyme activity and the ultraviolet inactivation of lysozyme","volume":"8","author":"Shugar, D.","year":"1952","unstructured":"Shugar D. Measurement of lysozyme activity and the ultraviolet inactivation of lysozyme. Biochim Biophys Acta 1952;8:302-9.","journal-title":"Biochim Biophys Acta"},{"key":"ref_16","first-page":"\"401","article-title":"Photometric determination","volume":"89","author":"Litwack, C.","year":"1977","unstructured":"Litwack C. Photometric determination of lysozyme activity. Proc Soc Exp Biol Med 1955;89:401-3. '' Heyderman E, Munro Neville A. A shorter immunoperoxidase technique for the demonstration of carcinoembryonic antigen and other cell products. J Clin Pathol 1977;30: 138-40. I Armitage P. Statistcal methods in medical research. Oxford, London, Melbourne: Blackwell Scientific Publications; 1971:123. '9 Erlandsen SL, Parsons JA, Taylor TD. Ultrastructural immunocytochemical localization of lysozyme in the Paneth cells of man. J Histochem Cytochem 1973;22:401-13.","journal-title":"of lysozyme activity. Proc Soc Exp Biol Med 1955; J Clin Pathol; Heyderman E, Munro Neville A. A shorter immunoperoxidase technique for the demonstration of carcinoembryonic antigen and other cell products"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/gut.20.1.55","article-title":"Jejunal lysozyme activity and the Paneth cell in coeliac disease","volume":"20","author":"Ward, M.; Ferguson, A.; Eastwood, M.A.","year":"1979","unstructured":"Ward M, Ferguson A, Eastwood MA. Jejunal lysozyme activity and the Paneth cell in coeliac disease. Gut 1979;20:55-8.","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/jcp.29.7.598","article-title":"Serum lysozyme in inflammatory bowel and coeliac disease","volume":"29","author":"Mailas, E.; Terry, J.M.; Asquith, P.; Cooke, W.T.","year":"1976","unstructured":"Mailas E, Terry JM, Asquith P, Cooke WT. Serum lysozyme in inflammatory bowel and coeliac disease. J Clin Pathol 1976;29:598-600.","journal-title":"J Clin Pathol"},{"key":"ref_19","first-page":"1099","article-title":"In vitro synthesis of lysozyme by human and mouse tissues and leucocytes","volume":"28","author":"McClelland, P.B.L.; van, Furth R.","year":"1975","unstructured":"McClelland PBL, Furth R van. In vitro synthesis of lysozyme by human and mouse tissues and leucocytes. Immunology 1975;28: 1099-114.","journal-title":"Immunology"},{"key":"ref_20","first-page":"365","article-title":"Serum muramidase","volume-title":"and granulocyte turnover. Proc Soc Exp Biol 1968","volume":"127","author":"Fink, M.E.; Finch, S.C.","unstructured":"Fink ME, Finch SC. Serum muramidase and granulocyte turnover. Proc Soc Exp Biol 1968;127:365-7."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.35.8.815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T02:28:44Z","timestamp":1764988124000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.35.8.815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8]]},"references-count":20,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1982,8,1]]},"published-print":{"date-parts":[[1982,8]]}},"alternative-id":["10.1136\/jcp.35.8.815"],"URL":"https:\/\/doi.org\/10.1136\/jcp.35.8.815","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,8]]}}}