{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:29:40Z","timestamp":1771572580552,"version":"3.50.1"},"reference-count":19,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1982,9]]},"abstract":"<jats:p>Serum glycocholic acid (SGC) was measured by radioimmunoassay in 277 samples from 122 children with hepatobiliary disorders and from 23 healthy age-matched controls. In patients with hepatobiliary disease the SGC was more frequently abnormal (83%) than values for serum albumin (7%), prothrombin time (17%), bilirubin (22%), alkaline phosphatase (45%), aspartate transaminase (57%) and gammaglutamyl transpeptidase (63%). The cumulative frequency of abnormality of these six tests was equal to that of SGC alone. Serum glycocholic acid concentrations were raised in 13 patients in whom all other tests of liver function were normal. Two of these had clinical and histological evidence of liver disease, while four had biopsy-proven hepatic fibrosis or cirrhosis, and two of three with chronic active hepatitis in remission subsequently relapsed. Four patients have as yet, no other clinical or biochemical evidence of continuing liver disease. Serum glycocholic acid was normal in seven children with abnormal aspartate transaminase or gammaglutamyl transpeptidase in whom there is strong suspicion of significant hepatic disease. A wide range of values of SGC was found with marked overlap between the values found in the different disease entities studied. The SGC value was related to the serum concentration of aspartate transaminase and gammaglutamyl transpeptidase but not to other tests of liver function. Serum glycocholic acid concentration was considered in relation to the severity of histological abnormality in 25 percutaneous liver biopsies. The extent of the rise in SGC was related to the presence or degree of histological severity of oedema in the portal tracts, disruption of the limiting plate, parenchymal fibrosis and hepatocellular necrosis but not to other histological features. The very high incidence of abnormal SGC values found in this study does suggest that in an ordinary inpatient and outpatient service SGC determination is a practical and sensitive indicator of the presence of significant liver disease but for its comprehensive identification aspartate transaminase and gammaglutamyl transpeptidase must also be determined.<\/jats:p>","DOI":"10.1136\/jcp.35.9.1011","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1011-1017","source":"Crossref","is-referenced-by-count":11,"title":["Radioimmunoassay of serum glycocholic acid, standard laboratory tests of liver function and liver biopsy findings: comparative study of children with liver disease."],"prefix":"10.1136","volume":"35","author":[{"given":"A","family":"Matsui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H T","family":"Psacharopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"Mowat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Portmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1001\/jama.1973.03220300048011","article-title":"Postprandial serum bile acid for the detection of hepatobiliary disease","volume":"225","author":"Kaplowitz, N.; Kok, E.; Javitt, N.B.","year":"1973","unstructured":"Kaplowitz N, Kok E, Javitt NB. Postprandial serum bile acid for the detection of hepatobiliary disease. JAMA 1973;225: 292-3.","journal-title":"JAMA"},{"key":"ref_2","first-page":"606","volume":"18","author":"man. Gut","year":"1977","unstructured":"man. Gut 1977;18:606-9."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/gut.18.11.903","article-title":"Serum bile acids in the diagnosis of hepatobiliary disease","volume":"18","author":"Pennington, C.R.; Ross, P.E.; Bouchier, A.D.","year":"1977","unstructured":"Pennington CR, Ross PE, Bouchier AD. Serum bile acids in the diagnosis of hepatobiliary disease. Gut 1977;18:903-8.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/BF01076191","article-title":"Fasting and postprandial serum as a screening test for hepatocellular disease","volume":"22","author":"Angelico, M.; Attili, A.F.; Capocaccia, L.","year":"1977","unstructured":"Angelico M, Attili AF, Capocaccia L. Fasting and postprandial serum as a screening test for hepatocellular disease. Dig Dis 1977;22: 941-6.","journal-title":"Dig Dis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/jcp.28.6.506","article-title":"Diagnostic value of serum bile acid estimations in liver disease","volume":"28","author":"Barnes, S.; Gallo, G.A.; Trash, D.B.; Morris, J.S.","year":"1975","unstructured":"Barnes S, Gallo GA, Trash DB, Morris JS. Diagnostic value of serum bile acid estimations in liver disease. J Clin Pathol 1975;28:506-9.","journal-title":"J Clin Pathol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF01071839","article-title":"Serum bile acids in alcoholic liver disease: comparison with histological features of the disease","volume":"21","author":"Milstein, J.H.; Bloomer, JR, Klatskin; G.","year":"1976","unstructured":"Milstein JH, Bloomer JR, Klatskin G. Serum bile acids in alcoholic liver disease: comparison with histological features of the disease. Dig Dis 1976;21:281-5.","journal-title":"Dig Dis"},{"key":"ref_7","first-page":"537","article-title":"Determination of serum bile acids and its use as a hepatic function test. Kawasaki MedJ 1975; 1: 55-67. h Fausa 0, Gjone E. Serum bile acid concentrations in patients with liver disease","volume":"11","author":"Kitazima, K.; Shibata, S.","year":"1976","unstructured":"Kitazima K, Shibata S. Determination of serum bile acids and its use as a hepatic function test. Kawasaki MedJ 1975;1:55-67. h Fausa 0, Gjone E. Serum bile acid concentrations in patients with liver disease. Scand J Gastroenterol 1976;11:537-43.","journal-title":"Scand J Gastroenterol"},{"key":"ref_8","first-page":"385","article-title":"Diagnostic significance of fasting serum bile acid in liver disease","volume":"23","author":"Hirayama, C.; Irisa, T.; Arimura, K.; Nakamura, M.","year":"1976","unstructured":"Hirayama C, Irisa T, Arimura K, Nakamura M. Diagnostic significance of fasting serum bile acid in liver disease. Acta Hepatogastroenterol (Stuttg) 1976;23: 385-91.","journal-title":"Acta Hepatogastroenterol (Stuttg)"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0009-8981(77)90502-2","article-title":"Evaluation of fluorimetrically estimated serum bile acid in liver disease","volume":"75","author":"Osuga, T.; Mitamura, K.; Mashige, F.; Kazuhiro, I.","year":"1977","unstructured":"Osuga T, Mitamura K, Mashige F, Kazuhiro I. Evaluation of fluorimetrically estimated serum bile acid in liver disease. Clin Chim Acta 1977;75:81-90.","journal-title":"Clin Chim Acta"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/clinchem\/24.7.1095","article-title":"Bile acids measured in serum during fasting as a test for liver disease","volume":"24","author":"Skrede, S.; Solberg, H.E.; Blomhoff, J.P.; Gjone, E.","year":"1978","unstructured":"Skrede S, Solberg HE, Blomhoff JP, Gjone E. Bile acids measured in serum during fasting as a test for liver disease. Clin Chem 1978;24: 1095-9.","journal-title":"Clin Chem"},{"key":"ref_11","first-page":"432","article-title":"Serum bile acids and routine liver function tests in patients with chronic liver disease and cholestasis","volume":"1","author":"Collins, D.M.; Tongeren, A.V.; Cook, H.B.; Campbell, C.B.","year":"1979","unstructured":"Collins DM, Tongeren AV, Cook HB, Campbell CB. Serum bile acids and routine liver function tests in patients with chronic liver disease and cholestasis. NZ Med J 1979;1:432-4.","journal-title":"NZ Med J"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/00007611-197708000-00020","article-title":"Radioimmunoassay of serum bile acid levels in biopsyproved cirrhosis","volume":"70","author":"Dasher, C.A.; Hirschowitz, B.I.; Spenney, J.G.; Gibson, R.G.; Mihas, A.A.","year":"1977","unstructured":"Dasher CA, Hirschowitz BI, Spenney JG, Gibson RG, Mihas AA. Radioimmunoassay of serum bile acid levels in biopsyproved cirrhosis. South Med J 1977;70:968-73.","journal-title":"South Med J"},{"key":"ref_13","first-page":"\"1399","article-title":"Assessment of activity in chronic active liver disease. Serum bile acids compared with conventional tests and histology","volume":"294","author":"Korman, M.G.; Hofmann, A.F.; Summerskill, W.H.J.","year":"1976","unstructured":"Korman MG, Hofmann AF, Summerskill WHJ. Assessment of activity in chronic active liver disease. Serum bile acids compared with conventional tests and histology. N Engl J Med 1976;294: 1399-1402. 'S Tobiasson P, Boeryd B. Serum cholic and chenodeoxycholic acid conjugates and standard liver function tests in various morphological stages of alcoholic liver disease. Scand J Gastroenterol 1980;15:657-63.","journal-title":"N Engl J Med; Serum cholic and chenodeoxycholic acid conjugates and standard liver function tests in various morphological stages of alcoholic liver disease"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/gut.22.2.141","article-title":"Clinical value of bile salt tests in anicteric liver disease","volume":"22","author":"Douglas, J.G.; Beckett, G.J.; Nimmo, I.A.; Finlayson, N.D.C.; PercyRobb, I.W.","year":"1981","unstructured":"Douglas JG, Beckett GJ, Nimmo IA, Finlayson NDC, PercyRobb IW. Clinical value of bile salt tests in anicteric liver disease. Gut 1981;22:141-8.","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1203\/00006450-197005000-00005","article-title":"Bile acid concentrations in serum during infancy and childhood","volume":"4","author":"Sandberg, D.H.","year":"1970","unstructured":"Sandberg DH. Bile acid concentrations in serum during infancy and childhood. Pediatr Res 1970;4:262-7.","journal-title":"Pediatr Res"},{"key":"ref_16","first-page":"908","article-title":"Prospective study in five patients","volume":"19","author":"B.","year":"1974","unstructured":"B. Prospective study in five patients. Dig Dis 1974;19:908-","journal-title":"Dig Dis"},{"key":"ref_17","first-page":"\"444","article-title":"Serum Glycine-conjugated bile acids in pediatric hepatobiliary disorders","volume":"71","author":"Lloyd-Still, J.D.; Demers, L.M.","year":"1979","unstructured":"Lloyd-Still JD, Demers LM. Serum Glycine-conjugated bile acids in pediatric hepatobiliary disorders. Am J Clin Pathol 1979;71:444-5 1. 20 Davidson GP, Corey M, Morad-Hassel F, Sondheimer JM, Crozier D, Forstner GG. Immunoassay of serum conjugates of cholic acid in cystic fibrosis. J Clin Pathol 1980;3:390-4.","journal-title":"Am J Clin Pathol; Immunoassay of serum conjugates of cholic acid in cystic fibrosis"},{"key":"ref_18","article-title":"Liver disorders in childhood","author":"Mowat, A.P.","year":"1979","unstructured":"Mowat AP. Liver disorders in childhood. London: Butterworths, 1979."},{"key":"ref_19","article-title":"Methods in medical research","author":"Armitage, P.","year":"1971","unstructured":"Armitage P. Methods in medical research. Oxford: Blackwell Scientific Publications, 1971."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.35.9.1011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:17:56Z","timestamp":1765599476000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.35.9.1011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,9]]},"references-count":19,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1982,9,1]]},"published-print":{"date-parts":[[1982,9]]}},"alternative-id":["10.1136\/jcp.35.9.1011"],"URL":"https:\/\/doi.org\/10.1136\/jcp.35.9.1011","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,9]]}}}