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Neither anaemia per se nor the metabolic defects of vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    or folic acid deficiency are likely to cause clinically significant lactic acidosis or hyperlactataemia.\n                  <\/jats:p>","DOI":"10.1136\/jcp.35.9.984","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"984-985","source":"Crossref","is-referenced-by-count":0,"title":["Acidosis and severe megaloblastic anaemia"],"prefix":"10.1136","volume":"35","author":[{"given":"IM","family":"Franklin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PBA","family":"Kernoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Isherwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Leek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DB","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,9,1]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Early mortality in the megaloblastic anaemias","volume":"41","author":"Lawson, D.H.; Murray, R.H.; Parker, J.W.L.","year":"1972","unstructured":"Lawson DH, Murray RH, Parker JWL. Early mortality in the megaloblastic anaemias. Q J Med 1972;41:1-14.","journal-title":"Q J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1600-0609.1976.tb01445.x","article-title":"Deaths from severe megaloblastic anaemia in hospitalised patients","volume":"17","author":"Lawson, D.H.; Parker, J.L.W.","year":"1976","unstructured":"Lawson DH, Parker JLW. Deaths from severe megaloblastic anaemia in hospitalised patients. Scand J Haematol 1976;17:347-52.","journal-title":"Scand J Haematol"},{"key":"ref_3","first-page":"77","article-title":"Potassium changes in megaloblastic anaemia","volume":"49","author":"Hesp, R.; Chanarin, I.; Tait, C.E.","year":"1975","unstructured":"Hesp R, Chanarin I, Tait CE. Potassium changes in megaloblastic anaemia. 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J Lab Clin Med 1967;69:177-82.","journal-title":"Am J Med; Assessment of tissue anoxemia in chronic anaemia by the arterial lactate\/pyruvate ratio and excess lactate formulation"},{"key":"ref_6","article-title":"Clinical and biochemical aspects oflactic acidosis","author":"Cohen, R.D.; Woods, H.F.","year":"1976","unstructured":"Cohen RD, Woods HF. Clinical and biochemical aspects oflactic acidosis. Oxford: Blackwell Scientific Publications, 1976."},{"key":"ref_7","article-title":"Microanalysis in medical biochemistry","author":"Wootton, I.D.P.","year":"1964","unstructured":"Wootton IDP. Microanalysis in medical biochemistry. 4th ed. London: Churchill, 1964.","edition":"4th ed"},{"key":"ref_8","article-title":"The determination of lactate, pyruvate, D3-hydroxybutyrate and acetoacetate in blood using an enzyme reaction rate analyser. MSc thesis","author":"Annan, W.","year":"1974","unstructured":"Annan W. The determination of lactate, pyruvate, D3-hydroxybutyrate and acetoacetate in blood using an enzyme reaction rate analyser. MSc thesis. University of Leeds, 1974."},{"key":"ref_9","first-page":"133","article-title":"The assessment of acid-base disturbance in man by the use of carbon dioxide titration curves","volume":"48","author":"Stoker, K.B.; Kappagoda, C.T.; Snow, H.M.","year":"1975","unstructured":"Stoker KB, Kappagoda CT, Snow HM, et al. The assessment of acid-base disturbance in man by the use of carbon dioxide titration curves. Clin Sci Mol Med 1975;48:133-8.","journal-title":"Clin Sci Mol Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1001\/jama.1972.03200160042012","article-title":"Lactic acidosis associated with iron deficiency anaemia","volume":"211","author":"Geerken, R.G.; Gibbons, R.B.","year":"1972","unstructured":"Geerken RG, Gibbons RB. Lactic acidosis associated with iron deficiency anaemia. JAMA 1972;211:292-3.","journal-title":"JAMA"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.35.9.984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:11:53Z","timestamp":1765710713000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.35.9.984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,9]]},"references-count":10,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1982,9,1]]},"published-print":{"date-parts":[[1982,9]]}},"alternative-id":["10.1136\/jcp.35.9.984"],"URL":"https:\/\/doi.org\/10.1136\/jcp.35.9.984","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1982,9]]}}}