{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:24:04Z","timestamp":1791854644199,"version":"4.3.4"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:p>Three cases of acute renal toxicity in patients receiving long-term therapy with mitomycin C and 5-fluorouracil are reported. Two of the patients (1 and 3) are from a multicentre trial of adjuvant chemotherapy for gastric carcinoma. All three cases showed extensive fibrin deposition in the kidneys and lungs, the appearances of the renal lesions being similar to those seen in the haemolytic-uraemic syndrome. Two of the three cases had received blood transfusions, and attention is drawn to the possibility that mitomycin C may sensitise the kidneys to minor mismatches. With the increasing use of these antimitotic agents, great vigilance should be exercised with regard to renal function and haemolytic status.<\/jats:p>","DOI":"10.1136\/jcp.36.1.24","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"24-29","source":"Crossref","is-referenced-by-count":25,"title":["Haemolytic-uraemic syndrome complicating long-term mitomycin C and 5-fluorouracil therapy for gastric carcinoma."],"prefix":"10.1136","volume":"36","author":[{"given":"J","family":"Crocker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E L","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1983,1,1]]},"reference":[{"key":"ref_1","first-page":"13","article-title":"Preliminary clinical pharmacology","volume-title":"of mitomycin C. Proc Am Cancer Res 1959; 3","author":"Colsky, C.J.; Escher, G.C.; Evans, A.","unstructured":"Colsky CJ, Escher GC, Evans A, et al. Preliminary clinical pharmacology of mitomycin C. Proc Am Cancer Res 1959;3:13."},{"key":"ref_2","article-title":"Clinical trials of mitomycin C, a new antitumour antibiotic","author":"Shiraha, Y.; Sakai, K.; Terenaka, T.","unstructured":"Shiraha Y, Sakai K, Terenaka T. Clinical trials of mitomycin C, a new antitumour antibiotic. In: Welch H, Marti-Ibanez F, eds."},{"key":"ref_3","first-page":"533","article-title":"Antibiotics annual","year":"1959","unstructured":"Antibiotics annual. New York: Med Encycl Inc, 1959:533-40."},{"key":"ref_4","first-page":"602","article-title":"Interstitial lung disease in a patient treated with 5-fluorouracil and mitomycin C","volume":"ii:","author":"Fielding, J.W.L.; Stockley, R.A.; Brookes, V.S.","year":"1978","unstructured":"Fielding JWL, Stockley RA, Brookes VS. Interstitial lung disease in a patient treated with 5-fluorouracil and mitomycin C. Br Med J 1978;ii:602.","journal-title":"Br Med J"},{"key":"ref_5","first-page":"551","article-title":"Interstitial fibrosis in a patient treated with 5-fluorouracil and mitomycin C","volume":"ii:","author":"Fielding, J.W.L.; Crocker, J.; Stockley, R.A.; Brookes, V.S.","year":"1979","unstructured":"Fielding JWL, Crocker J, Stockley RA, Brookes VS. Interstitial fibrosis in a patient treated with 5-fluorouracil and mitomycin C. Br Med J 1979;ii: 551.","journal-title":"Br Med J"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/1097-0142(1971)28:5<1314::AID-CNCR2820280534>3.0.CO;2-D","article-title":"Renal toxicity in man treated with mitomycin C","volume":"28","author":"Liu, K.; Mittelman, A.; Sproul, E.E.; Elias, E.G.","year":"1971","unstructured":"Liu K, Mittelman A, Sproul EE, Elias EG. Renal toxicity in man treated with mitomycin C. Cancer 1971;28: 1314-20.","journal-title":"Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/1097-0142(19811215)48:12<2583::AID-CNCR2820481208>3.0.CO;2-6","article-title":"Renal disease after mitomycin C therapy","volume":"48","author":"Hanna, W.T.; Krauss, S.; Regester, R.F.; Murphy, W.M.","year":"1981","unstructured":"Hanna WT, Krauss S, Regester RF, Murphy WM. Renal disease after mitomycin C therapy. Cancer 1981;48:2583-8.","journal-title":"Cancer"},{"key":"ref_8","first-page":"1275","article-title":"Intravascular haemolysis and renal impairment after blood transfusion in two patients after long-term 5-fluorouracil and mitomycin C","volume":"i:","author":"Jones, B.G.; Fielding, J.W.; Newman, C.E.; Howell, A.; Brookes, V.S.","year":"1980","unstructured":"Jones BG, Fielding JW, Newman CE, Howell A, Brookes VS. Intravascular haemolysis and renal impairment after blood transfusion in two patients after long-term 5-fluorouracil and mitomycin C. Lancet 1980;i: 1275-6.","journal-title":"Lancet"},{"key":"ref_9","first-page":"137","article-title":"Diseases of the kidney","volume-title":"Recent advances in pathology. Churchill-Livingstone, Edinburgh, London and","author":"Tighe, JR","year":"1975","unstructured":"Tighe JR. Diseases of the kidney. In: Harrison CV, Weinbren K, eds. Recent advances in pathology. Churchill-Livingstone, Edinburgh, London and New York: 1975;137-47."},{"key":"ref_10","article-title":"Renal histopathology","author":"Meadows, R.","year":"1978","unstructured":"Meadows R. Renal histopathology. Oxford University Press, 1978."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2141.1970.tb01433.x","article-title":"Micro angiopathic haemolytic anaemia and mucinforming adenocarcinoma","volume":"18","author":"Brain, M.C.; Azzopardi, J.G.; Baker, L.R.I.; Pineo, G.F.; Roberts, P.D.; Dacie, J.V.","year":"1970","unstructured":"Brain MC, Azzopardi JG, Baker LRI, Pineo GF, Roberts PD, Dacie JV. Micro angiopathic haemolytic anaemia and mucinforming adenocarcinoma. Br J Haematol 1970;18:183-93.","journal-title":"Br J Haematol"},{"key":"ref_12","first-page":"88","article-title":"Microangiopathic haemolytic anaemia in carcinoma","volume-title":"of the stomach. Gastroenterology 1967; 52","author":"Lynch, E.C.; Bakken, C.L.; Casey, T.H.; Alfrey, C.P.","unstructured":"Lynch EC, Bakken CL, Casey TH, Alfrey CP. Microangiopathic haemolytic anaemia in carcinoma of the stomach. Gastroenterology 1967;52:88-93."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/1097-0142(197905)43:5<1598::AID-CNCR2820430505>3.0.CO;2-Y","article-title":"Treatment of advanced gastrointestinal cancer with 5-fluorouracil and mitomycin C","volume":"43","author":"Krauss, S.; Sonoda, T.; Solomon, A.","year":"1979","unstructured":"Krauss S, Sonoda T, Solomon A. Treatment of advanced gastrointestinal cancer with 5-fluorouracil and mitomycin C. Cancer 1979;43: 1598-603.","journal-title":"Cancer"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.36.1.24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:57:28Z","timestamp":1758905848000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.36.1.24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1983,1,1]]},"published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1136\/jcp.36.1.24"],"URL":"https:\/\/doi.org\/10.1136\/jcp.36.1.24","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}