{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:23:27Z","timestamp":1763749407916,"version":"3.45.0"},"reference-count":25,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:p>Fifteen cases of large-cell lymphoma, diagnosed as centroblastic (5), B-immunoblastic (5) or true histiocytic (5). lymphoma and one case of malignant histiocytosis were studied with monoclonal antibodies. Each diagnosis was based on morphological as well as marker studies. A panel of monoclonal and heterologous antibodies against T lymphocyte differentiation antigens (Leul, Leu2a, Leu3a, OKT4, OKT8, TA1), B lymphocyte subsets (BA1, BA2, HLA-DR, alpha C3b receptor antiserum, surface immunoglobulins), the common acute lymphoblastic leukaemia antigen (CALLA), monocytes\/macrophages (OKM1, anti-human monocyte 1, TA1, Mac1, HLA-DR, anti-C3b receptor), myeloid cells (VIM-D5, elastase, OKM1) and the cells of the Langerhans cell\/interdigitating reticulum cell series (OKT6, NA1\/34). The results show a specific staining pattern for true histiocytic lymphoma (histiocytic sarcoma). Centroblastic and B-immunoblastic lymphomas showed gradual differences with mostly strong staining for HLA-DR and weak with anti C3b receptor for B-immunoblastic lymphomas in contrast to centroblastic lymphomas. Staining with BA1 and BA2 indicated immunological heterogeneity in these lymphomas. The number of admixed cells was usually low with few B cells and a shift in the ratio helper\/inducer to suppressor\/cytotoxic T cells in favour of the suppressor\/cytotoxic subset.<\/jats:p>","DOI":"10.1136\/jcp.36.1.44","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"44-50","source":"Crossref","is-referenced-by-count":15,"title":["Analysis of large-cell lymphomas using monoclonal and heterologous antibodies."],"prefix":"10.1136","volume":"36","author":[{"given":"P","family":"van der Valk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"van den Besselaar-Dingjan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R","family":"Daha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C J","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,1,1]]},"reference":[{"key":"ref_1","first-page":"53","article-title":"The influence of fixation on itimmunoperoxidase staining of plasma cells in paraft'in sections of intestinal btopsy specimilens","author":"J, Bosman F.T.Kreuning; van der Wal AM. 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The Netherlands."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.36.1.44","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:03:29Z","timestamp":1763748209000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.36.1.44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1983,1,1]]},"published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1136\/jcp.36.1.44"],"URL":"https:\/\/doi.org\/10.1136\/jcp.36.1.44","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}