{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:14:08Z","timestamp":1790788448025,"version":"4.1.0"},"reference-count":18,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:p>The haematological features of 118 cases of primary myelodysplastic syndromes (PMDS) were reviewed to see how these could be related and classified according to the recent FAB proposals. A majority of the cases were elderly who presented with a macrocytic or normocytic anaemia and reticulocytopenia. Cases of acquired idiopathic sideroblastic anaemia (AISA) usually had normal leucocyte and platelet counts, erythroid hyperplasia, marked dyserythropoiesis and more than 20% ringed sideroblasts. Cases of refractory anaemia with excess of blasts (RAEB) had frequent neutropenia and thrombopenia usually with prominent dysgranulopoiesis and dysthrombopoiesis. Refractory anaemia or refractory cytopenia appeared morphologically to be a heterogeneous group. Leukaemic transformation did not occur in any of these 16 cases of AISA whereas six of the 34 cases of RAEB transformed into acute leukaemia. It appears that the cases of PMDS present with well defined haematological features which permit recognition of different groups; these latter groups appear to be morphologically and prognostically distinct.<\/jats:p>","DOI":"10.1136\/jcp.36.10.1129","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1129-1135","source":"Crossref","is-referenced-by-count":64,"title":["Haematological features of primary myelodysplastic syndromes (PMDS) at initial presentation: a study of 118 cases."],"prefix":"10.1136","volume":"36","author":[{"given":"S K","family":"Juneja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Imbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Jouault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Y","family":"Scoazec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Sigaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1983,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1182\/blood.V11.3.250.250","article-title":"Chronic refractory anemia with sideroblastic bone marrow: a study of 4 cases","volume":"n:","author":"Bjorkman, S.E.","year":"1956","unstructured":"Bjorkman SE. Chronic refractory anemia with sideroblastic bone marrow: a study of 4 cases. Blood 1956; n:250-8.","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1001\/jama.1953.03690110032010","article-title":"Preleukemic acute human leukemia","volume":"152","author":"Block, M.; Jacobson, L.O.","year":"1953","unstructured":"Block M, Jacobson LO. Preleukemic acute human leukemia. JAMA 1953;152:1018-28.","journal-title":"JAMA"},{"key":"ref_3","first-page":"140","article-title":"Preleukemic states. Blood Cells 1976; 2: 33-45. '3 Varela BL","volume":"60","author":"Dreyfus, B.","year":"1982","unstructured":"Dreyfus B. Preleukemic states. Blood Cells 1976;2:33-45. '3 Varela BL Chuang C, Bennett JM. Clinical significance of the new proposals for the classification of the myelodysplastic syndromes (abstract). Blood 1982;60(Suppl):140.","journal-title":"Blood; Clinical significance of the new proposals for the classification of the myelodysplastic syndromes (abstract"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"Proposals for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennett, J.M.; Catovsky, D.; Daniel, M.T.","year":"1982","unstructured":"Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982;51: 189-99.","journal-title":"Br J Haematol"},{"key":"ref_5","article-title":"The myelodysplastic syndromes. Hematology transfusion","author":"Pierre, R.; Sultan, C.; Vardiman, J.","year":"1982","unstructured":"Pierre R, Sultan C, Vardiman J. The myelodysplastic syndromes. Hematology transfusion. In: McArthur JR, ed. The education program ofAmerican Society of Hematology 1982:1."},{"key":"ref_6","article-title":"Myelodysplastic syndrome or acute myeloid leukemia? A study of 35 cases presenting with borderline features","volume":"62","author":"Imbert, M.; Scoazec, J.Y.; Croft, M.","year":"1983","unstructured":"Imbert M, Scoazec JY, Croft M, et al. Myelodysplastic syndrome or acute myeloid leukemia? A study of 35 cases presenting with borderline features. Blood 1983;62 (suppl).","journal-title":"Blood"},{"key":"ref_7","first-page":"111","article-title":"Myelodysplasia and leukaemia related to chemotherapy and\/ or radiotherapy-a haematological study of 13 cases. Value of macrocytosis as an early sign of bone marrow injury. Clin Lab Haematol 1980; 2","unstructured":"Dohy H, Genot JY, Imbert M, Ricard d'Agay MF, Sultan C. Myelodysplasia and leukaemia related to chemotherapy and\/ or radiotherapy-a haematological study of 13 cases. Value of macrocytosis as an early sign of bone marrow injury. Clin Lab Haematol 1980;2:111-9."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2141.1981.tb07191.x","article-title":"Acute myelodysplasia with myelofibrosis: a report of 8 cases","volume":"49","author":"Sultan, C.; Sigaux, F.; Imbert, M.; Reyes, F.","year":"1981","unstructured":"Sultan C, Sigaux F, Imbert M, Reyes F. Acute myelodysplasia with myelofibrosis: a report of 8 cases. Br J Haematol 1981;49: 11-6.","journal-title":"Br J Haematol"},{"key":"ref_9","article-title":"Techniques en Hematologie","author":"Sultan, C.; Priolet, G.; Beuzard, Y.; Rosa, R.; Josso, F.","year":"1978","unstructured":"Sultan C, Priolet G, Beuzard Y, Rosa R, Josso F. Techniques en Hematologie. 2nd ed. Paris: Flammarion M6ddcineSciences, 1978.","edition":"2nd ed"},{"issue":"18","key":"ref_10","first-page":"662","article-title":"Abnormal (\"ringed\") sideroblasts in various hematologic and non-hematological disorders","volume":"1961","author":"Bowman, W.D.","unstructured":"Bowman WD. Abnormal (\"ringed\") sideroblasts in various hematologic and non-hematological disorders. Blood 1961;18:662-71.","journal-title":"Blood"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0308-2261(21)00344-1","article-title":"Sideroblastic anaemia","volume":"11","author":"Bottomley, S.S.","year":"1982","unstructured":"Bottomley SS. Sideroblastic anaemia. Clin Haematol 1982;11:389-409.","journal-title":"Clin Haematol"},{"key":"ref_12","first-page":"169","article-title":"Decreased ribosomal RNA content and in vitro RNA synthesis in purified bone marrow erythroblasts of patients with idiopathic ineffective erythropoiesis and","volume":"5","author":"Laurenco, G.; Embury, S.; Schrier, S.L.; Kedes, L.H.","year":"1978","unstructured":"Laurenco G, Embury S, Schrier SL, Kedes LH. Decreased ribosomal RNA content and in vitro RNA synthesis in purified bone marrow erythroblasts of patients with idiopathic ineffective erythropoiesis and Di Guglielmo disease. Am J Hematol 1978;5: 169-82.","journal-title":"Di Guglielmo disease. Am J Hematol"},{"key":"ref_13","first-page":"34552","article-title":"Capacity of ringed sideroblasts to synthesize nucleic acids and protein in patients with primary acquired sideroblastic anaemia","volume":"38","author":"Wickramasinghe, S.N.; Hughes, M.","year":"1978","unstructured":"Wickramasinghe SN, Hughes M. Capacity of ringed sideroblasts to synthesize nucleic acids and protein in patients with primary acquired sideroblastic anaemia. Br J Haematol 1978;38:34552.","journal-title":"Br J Haematol"},{"key":"ref_14","first-page":"139","article-title":"Sideroblastic anemia in dyserythropoiesis","author":"Hoffbrand, A.V.","year":"1977","unstructured":"Hoffbrand AV. Sideroblastic anemia in dyserythropoiesis. In: Lewis SM, Verwilghen RL, eds. London: Academic Press, 1977:139-49."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1182\/blood.V50.3.427.427","article-title":"Prognostic significance of thrombocytosis in idiopathic sideroblastic anemia","volume":"50","author":"Streeter, R.G.; Presant, C.A.; Reinhard, E.","year":"1977","unstructured":"Streeter RG, Presant CA, Reinhard E. Prognostic significance of thrombocytosis in idiopathic sideroblastic anemia. Blood 1977;50:427-32.","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/274590a0","article-title":"A common progenitor for human myeloid and lymphoid cells","volume":"274","author":"Prchal, J.T.; Throckmorton, D.W.; Carroll, A.J.; Frison, E.W.; Game, R.A.; Prchal, J.F.","year":"1978","unstructured":"Prchal JT, Throckmorton DW, Carroll AJ, Frison EW, Game RA, Prchal JF. A common progenitor for human myeloid and lymphoid cells. Nature 1978;274:590-1.","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/1097-0142(197701)39:1<359::AID-CNCR2820390155>3.0.CO;2-C","article-title":"Idiopathic acquired sideroblastic anemia terminating in acute myelofibrosis","volume":"39","author":"Yeung, K.Y.; Trowbridge, A.A.","year":"1977","unstructured":"Yeung KY, Trowbridge AA. Idiopathic acquired sideroblastic anemia terminating in acute myelofibrosis. Cancer 1977;39:359-65.","journal-title":"Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1002\/1097-0142(19820615)49:12<2497::AID-CNCR2820491215>3.0.CO;2-X","article-title":"Idiopathic acquired sideroblastic anemia terminating in acute myelosclerosis","volume":"49","author":"Butler, W.M.; Taylor, G.; Vishwanathan, U.","year":"1982","unstructured":"Butler WM, Taylor G, Vishwanathan U. Idiopathic acquired sideroblastic anemia terminating in acute myelosclerosis. Cancer 1982;49:2497-9.","journal-title":"Cancer"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.36.10.1129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:14:51Z","timestamp":1765703691000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.36.10.1129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":18,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1983,10,1]]},"published-print":{"date-parts":[[1983,10]]}},"alternative-id":["10.1136\/jcp.36.10.1129"],"URL":"https:\/\/doi.org\/10.1136\/jcp.36.10.1129","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,10]]}}}