{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:16:43Z","timestamp":1758845803922,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1983,11]]},"abstract":"<jats:p>Morphological and functional abnormalities of the megakaryocytic series have been well described in myelodysplastic syndromes. Platelet peroxidase has always been demonstrated in abnormal megakaryocytes and early megakaryoblasts in such syndromes. We have studied a case of myelodysplastic syndrome with marked morphological abnormalities of megakaryocytes in which ultrastructural studies showed the coexistence of platelet peroxidase positive and platelet peroxidase negative megakaryocytes. This enzymatic deficiency was confirmed by the ultrastructural study of circulating platelets. This case appears to be the first report of a partial platelet peroxidase deficiency. It adds to the enzymatic abnormalities in myelodysplastic syndrome already described for the red cells and the granulocytic cells.<\/jats:p>","DOI":"10.1136\/jcp.36.11.1223","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1223-1228","source":"Crossref","is-referenced-by-count":3,"title":["Platelet peroxidase deficiency in a case of myelodysplastic syndrome with myelofibrosis."],"prefix":"10.1136","volume":"36","author":[{"given":"M","family":"Imbert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M T","family":"Jarry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Tulliez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Breton-Gorius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,11,1]]},"reference":[{"key":"ref_1","first-page":"33","article-title":"Preleukemic states. 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Histochemistry 1975;41:281-312.","journal-title":"Histochemistry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-2141.1978.tb01101.x","article-title":"The blast crisis of chronic granulocytic leukaemia: megakaryoblastic nature of cells as revealed by the presence of platelet-peroxidase. A cytochemical ultrastructural study","volume":"39","author":"Breton-Gorius, J.; Reyes, F.; Vemant, J.P.; Tulliez, M.; Dreyfus, B.","year":"1978","unstructured":"Breton-Gorius J, Reyes F, Vemant JP, Tulliez M, Dreyfus B. The blast crisis of chronic granulocytic leukaemia: megakaryoblastic nature of cells as revealed by the presence of platelet-peroxidase. A cytochemical ultrastructural study. 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