{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:43:38Z","timestamp":1765730618489,"version":"3.48.0"},"reference-count":26,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1983,5]]},"abstract":"<jats:p>We measured cytofluorometrically the concentration of 5-hydroxytryptamine (5-HT, serotonin) of individual enterochromaffin (EC) cells in adult coeliac and non-coeliac small intestinal mucosa. The distributions of 5-HT concentration within populations of EC cells in control and coeliac mucosae were log normal and thus contained one single population of EC cells. The median 5-HT concentration per EC cell, and the number of EC cells both increased in coeliac disease, but showed signs of normalisation when gluten was withdrawn from the diet. The results indicate that, besides inducing EC cell hyperplasia, gluten is capable of producing reversible changes in functions of EC cells in adult coeliac disease.<\/jats:p>","DOI":"10.1136\/jcp.36.5.499","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"499-503","source":"Crossref","is-referenced-by-count":15,"title":["Raised 5-hydroxytryptamine concentrations in enterochromaffin cells in adult coeliac disease."],"prefix":"10.1136","volume":"36","author":[{"given":"L","family":"Enerb\u00e4ck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Hallert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Norrby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,5,1]]},"reference":[{"key":"ref_1","first-page":"504","article-title":"Blood serotonin","volume-title":"nontropical sprue. 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Increased excretion of 5-hydroxyindoleacetic acid in urine of children with untreated coeliac disease.Arch Dis Child 1972;47:442-8.","journal-title":"Arch Dis Child"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/gut.18.11.882","article-title":"Increased tissue concentrations of 5-hydroxytryptamine in the duodenal mucosa of patients with coeliac disease","volume":"18","author":"Challacombe, D.N.; Dawkins, P.D.; Baker, P.","year":"1977","unstructured":"Challacombe DN, Dawkins PD, Baker P. Increased tissue concentrations of 5-hydroxytryptamine in the duodenal mucosa of patients with coeliac disease. 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Cytofluorometric quantitation of 5-hydroxytryptamine in mast cells: An improved method for the formaldehyde condensation reaction. J Histochem Cytochem 1977;25:32-41.","journal-title":"J Histochem Cytochem"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF00508378","article-title":"DNA distribution of mast cell populations of growing rats","volume":"71","author":"Enerback, L.; Rundquist, I.","year":"1981","unstructured":"Enerback L, Rundquist I. DNA distribution of mast cell populations of growing rats. Histochemistry 1981;71:521-31.","journal-title":"Histochemistry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0014-4827(67)90122-X","article-title":"Quantitative fluorescence microspectrophotometry of 5-hydroxytryptamine-formaldehyde products in models and in mast cells","volume":"45","author":"Ritzen, M.","year":"1966","unstructured":"Ritzen M. 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Tunbridge Wells: Pitman Medical, 1980: 141-54."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.36.5.499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:41:32Z","timestamp":1765730492000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.36.5.499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,5]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1983,5,1]]},"published-print":{"date-parts":[[1983,5]]}},"alternative-id":["10.1136\/jcp.36.5.499"],"URL":"https:\/\/doi.org\/10.1136\/jcp.36.5.499","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1983,5]]}}}