{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:06:08Z","timestamp":1764493568110,"version":"3.45.0"},"reference-count":14,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:p>In a twenty-year period 19 appendicectomy specimens were diagnosed as primary Crohn's disease. This represents 4.9% of the total number of both resection specimens and mucosal biopsies diagnosed as Crohn's disease during that time. This is a review of the main histopathological features found in these appendices and their subsequent clinical outcome. The predominant feature is transmural inflammation characterised by fibrosis and giant cell epithelioid granulomata. An accompanying spectrum of acute imflammatory changes is also seen. One patient progressed to more widespread ileal and caecal disease 17 months later. One patient developed perianal fistulae and chronic non-specific proctitis 24 months later. This represents a proven recurrence of one case in a study population of 19. The conclusion is that primary Crohn's disease of the appendix is usually an isolated phenomenon but rarely it may forewarn of more widespread bowel disease in the future. A discussion regarding the differential diagnosis of granulomatous appendiceal lesions is included.<\/jats:p>","DOI":"10.1136\/jcp.36.6.632","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"632-638","source":"Crossref","is-referenced-by-count":30,"title":["Granulomatous disease in the vermiform appendix."],"prefix":"10.1136","volume":"36","author":[{"given":"D C","family":"Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Biggart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,6,1]]},"reference":[{"issue":"99","key":"ref_1","first-page":"1323","article-title":"Regional ileitis: a pathologic and clincal entity","volume":"1932","author":"Crohn, B.B.; Ginzburg, L.; Oppenheimer, G.D.","unstructured":"Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis: a pathologic and clincal entity. JAMA 1932;99: 1323-9.","journal-title":"JAMA"},{"key":"ref_2","first-page":"475","article-title":"Cicatrising enteritis (regional ileitis) as a pathologic entity: analysis of one hundred and twenty cases","volume":"24","author":"Warren, S.; Sommers, S.C.","year":"1948","unstructured":"Warren S, Sommers SC. Cicatrising enteritis (regional ileitis) as a pathologic entity: analysis of one hundred and twenty cases. Am J Pathol 1948;24:475-501.","journal-title":"Am J Pathol"},{"key":"ref_3","first-page":"891","article-title":"Non-specific granulomatous inflammation (Crohn's disease) of the appendix","volume":"34","author":"Meyerding, E.V.; Bertram, H.F.","year":"1953","unstructured":"Meyerding EV, Bertram HF. Non-specific granulomatous inflammation (Crohn's disease) of the appendix. Surgery 1953;34:891-4.","journal-title":"Surgery"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.5694\/j.1326-5377.1964.tb114101.x","article-title":"Crohn's disease of the appendix","volume":"1","author":"Hollings, R.M.","year":"1964","unstructured":"Hollings RM. Crohn's disease of the appendix. Med J Aust 1964;1:639-41.","journal-title":"Med J Aust"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/bjs.1800560518","article-title":"Crohn's disease of the appendix presenting as acute appendicitis","volume":"56","year":"1969","unstructured":"Hall JH, Hellier MD. Crohn's disease of the appendix presenting as acute appendicitis. Br J Surg 1969;56:390-2.","journal-title":"Br J Surg"},{"key":"ref_6","first-page":"290","article-title":"Isolated regional ileitis of the appendix","volume":"54","author":"Ring, A.M.","year":"1970","unstructured":"Ring AM. Isolated regional ileitis of the appendix. Int Surg 1970;54:290-4.","journal-title":"Int Surg"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0016-5085(71)80084-7","article-title":"Crohn's disease initially confined to the appendix","volume":"60","year":"1971","unstructured":"Crohn's disease initially confined to the appendix. Gastroenterology 1971;60:853-7.","journal-title":"Gastroenterology"},{"key":"ref_8","first-page":"349","article-title":"Crohn's disease of the appendix","volume":"39","author":"Hobson, R.W.; Howard, E.W.; Tuttle, JR, Jenis; E.H.","year":"1973","unstructured":"Hobson RW, Howard EW, Tuttle JR, Jenis EH. Crohn's disease of the appendix. Am Surg 1973;39:349-51.","journal-title":"Am Surg"},{"key":"ref_9","first-page":"\"215","article-title":"Isolated Crohn's disease of the appendix: case report","volume":"139","author":"Geerken, R.G.; Gibbons, R.B.","year":"1974","unstructured":"Geerken RG, Gibbons RB. Isolated Crohn's disease of the appendix: case report. Milit Med 1974;139:215-7. 1\u00b0 Weiss Y, Durst AL. Crohn's disease of the appendix: presentation of a case with review of the literature. Am J Gastroenterol 1975;63:334-9.","journal-title":"Milit Med; Crohn's disease of the appendix: presentation of a case with review of the literature"},{"key":"ref_10","first-page":"74","article-title":"Crohn's disease of the appendix presenting as acute appendicitis","volume":"65","author":"Green, G.I.; Broadrick, G.L.; Collins, J.L.","year":"1976","unstructured":"Green GI, Broadrick GL, Collins JL. Crohn's disease of the appendix presenting as acute appendicitis. Am J Gastroenterol 1976;65:74-7.","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"ref_11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00000658-197903000-00014","article-title":"Primary Crohn's disease of the appendix: report of 14 cases and review of the literature","volume":"189","author":"Yang, S.S.; Gibson, P.; McCaughey, R.S.; Arcari, F.A.; Bernstein, J.","year":"1979","unstructured":"Yang SS, Gibson P, McCaughey RS, Arcari FA, Bernstein J. Primary Crohn's disease of the appendix: report of 14 cases and review of the literature. Ann Surg 1979;189\/3:334-9.","journal-title":"Ann Surg"},{"key":"ref_12","article-title":"Gastrointestinal Pathology","author":"Morson, B.C.; Dawson, I.M.P.","year":"1979","unstructured":"Morson BC, Dawson IMP. Gastrointestinal Pathology 2nd ed. Oxford: Blackwell, 1979.","edition":"2nd ed"},{"issue":"2","key":"ref_13","first-page":"5713","article-title":"Sarcoidosis involving the vermiform appendix. J R Coll Surg Edinb 1965; 10: 319-23. ' Mitchell DN, Cannon","volume":"1969","author":"Macleod, I.B.; Jenkins, A.M.; Gill, W.","unstructured":"Macleod IB, Jenkins AM, Gill W. Sarcoidosis involving the vermiform appendix. J R Coll Surg Edinb 1965;10:319-23. ' Mitchell DN, Cannon P, Dyer NH, Hinson KFW, Willoughby JMT. The Kveim test in Crohn's disease. Lancet 1969;2:5713.","journal-title":"Lancet; The Kveim test in Crohn's disease"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/gut.5.6.493","article-title":"Crohn's disease of the large intestine","volume":"5","author":"Lockhart-Mummery, H.E.; Morson, B.C.","year":"1964","unstructured":"Lockhart-Mummery HE, Morson BC. Crohn's disease of the large intestine. Gut 1964;5:493-509.","journal-title":"Gut"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.36.6.632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:42:43Z","timestamp":1763746963000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.36.6.632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6]]},"references-count":14,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1983,6,1]]},"published-print":{"date-parts":[[1983,6]]}},"alternative-id":["10.1136\/jcp.36.6.632"],"URL":"https:\/\/doi.org\/10.1136\/jcp.36.6.632","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1983,6]]}}}