{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T19:21:13Z","timestamp":1768418473588,"version":"3.49.0"},"reference-count":14,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1983,9]]},"abstract":"<jats:p>Thirty-seven patients with SCD were studied: 24 were diagnosed as homozygous Hb S on the basis of their haematological findings, and alpha:non-alpha globin chain ratios were found to be balanced in all. Thirteen patients were thought to have alpha or beta thalassaemia interaction with Hb S on the basis of low MCV and MCH, family history and\/or presence of Hb A on electrophoresis. Six of them had abnormal alpha:non-alpha ratio (one had a ratio of 0.72 suggestive of alpha thalassaemia, and five had ratios between 1.4 and 1.9, compatible with beta thalassaemia interaction). The remaining seven patients with microcytosis had balanced globin chain synthesis and five were found to be iron deficient. Five additional patients (3 with Hb SS and 2 with Hb S\/beta thalassaemia) had lower than normal serum ferritin concentration. The analysis of case histories disclosed that peptic ulceration, recurrent epistaxis and multiple pregnancies could account for iron loss in seven patients. These findings indicate that iron deficiency may be common in SCD and should be excluded as a cause of microcytosis. Microcytosis, in the absence of conclusive family studies and\/or presence of Hb A on electrophoresis, is an unreliable indicator of alpha or beta thalassaemia interaction with Hb S.<\/jats:p>","DOI":"10.1136\/jcp.36.9.1012","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1012-1015","source":"Crossref","is-referenced-by-count":24,"title":["Iron deficiency in sickle cell anaemia."],"prefix":"10.1136","volume":"36","author":[{"given":"S","family":"Davies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Henthorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Brozovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,9,1]]},"reference":[{"key":"ref_1","first-page":"65","author":"Iron, Hoffbrand A.V.","year":"1981","unstructured":"Hoffbrand AV. Iron. In: Lewis SM, Hoffbrand AV, eds. Postgraduate haematology London: William Heinemann, 1981:65-9."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ajh.2830060202","article-title":"The association of sickle cell anaemia with heterozygous and homozygous a2 thalassaemia: in vitro Hb chain synthesis","volume":"6","author":"Felice, A.E.; Webber, B.; Miller, B.","year":"1979","unstructured":"Felice AE, Webber B, Miller B, et al. The association of sickle cell anaemia with heterozygous and homozygous a2 thalassaemia: in vitro Hb chain synthesis. Am J Hematol 1979;6:91-106.","journal-title":"Am J Hematol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1056\/NEJM198202043060504","article-title":"Concurrent sickle cell anemia and thalassemia","volume":"306","author":"Embury, S.H.; Dozy, A.M.; Miller, J.","year":"1982","unstructured":"Embury SH, Dozy AM, Miller J, et al. Concurrent sickle cell anemia and thalassemia. 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Br J Hae'natol 1972;23:205-16.","journal-title":"Br J Hae'natol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/adc.53.4.319","article-title":"Value of serum ferritin estimation in sickle cell anaemia","volume":"53","author":"Hussain, A.M.; Davis, L.R.; Lanlicht, M.; Hoffbrand, A.V.","year":"1978","unstructured":"Hussain AM, Davis LR, Lanlicht M, Hoffbrand AV. Value of serum ferritin estimation in sickle cell anaemia. Arch Dis Child 1978;53:319-21.","journal-title":"Arch Dis Child"},{"key":"ref_7","first-page":"579","article-title":"Iron metabolism, sickle cell disease, and response to cyanate. Blood 1975; 46: 583-90. 'O'Brien RT. Iron burden in sickle cell anaemia","volume":"92","author":"Peterson, C.M.; Graziano, J.H.; de Cinitis, A.","year":"1978","unstructured":"Peterson CM, Graziano JH, de Cinitis A, et al. Iron metabolism, sickle cell disease, and response to cyanate. Blood 1975;46:583-90. 'O'Brien RT. Iron burden in sickle cell anaemia. 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Nature 1959;184:1877-8.","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1136\/jcp.18.1.98","article-title":"Method for automatic determination of serum iron","volume":"18","author":"Young, D.S.; Hicks, J.M.","year":"1965","unstructured":"Young DS, Hicks JM. Method for automatic determination of serum iron. J Clin Pathol 1965;18:98-102.","journal-title":"J Clin Pathol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/jcp.25.4.326","article-title":"An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and overload","volume":"25","author":"Addison, G.M.; Beamish, M.R.; Hales, C.M.; Hodkins, M.; Jacobs, A.; Llewellin, R.","year":"1972","unstructured":"Addison GM, Beamish MR, Hales CM, Hodkins M, Jacobs A, Llewellin R. An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and overload. 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