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In the adults, there was no significant increase in the parameters of bone resorption or in the bone formation rates at the basic multicellular unit and the tissue levels. Thus the histomorphometric profile of iliac bone in osteogenesis imperfecta is characterised by cortical and trabecular osteoporosis with decreased activity of the individual osteoblasts. These findings would suggest the use of therapeutic agents stimulating bone formation rather than agents inhibiting bone resorption in osteogenesis imperfecta.<\/jats:p>","DOI":"10.1136\/jcp.37.10.1081","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1081-1089","source":"Crossref","is-referenced-by-count":35,"title":["Iliac bone histomorphometry in adults and children with osteogenesis imperfecta."],"prefix":"10.1136","volume":"37","author":[{"given":"L G","family":"Ste-Marie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Charhon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Edouard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Chapuy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Meunier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,10,1]]},"reference":[{"issue":"11 -25","key":"ref_1","article-title":"Osteogenesis imperfecta: an expanding panorama of variants","volume":"159","author":"Sillence, D.","year":"1981","unstructured":"Sillence D. 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