{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:14:11Z","timestamp":1773274451494,"version":"3.50.1"},"reference-count":9,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1984,2]]},"abstract":"<jats:p>The distribution of an epitope of the transferrin receptor in the human uterine cervical epithelium has been investigated. Immunohistochemical staining, both immunofluorescent and immunoperoxidase, was performed on biopsy specimens and cytological samples from normal, dysplastic, and neoplastic cervical epithelia using the monoclonal OKT9 antibody. The results of staining 145 cervical biopsy specimens with OKT9 showed widespread staining in all malignant epithelia and most severely dysplastic epithelia. No such staining was seen in either normal epithelia or in mildly dysplastic epithelia apart from the staining of the basal cell layer in some normal epithelia. The incidence of staining in the 50 cervical cytocentrifuge preparations was not as high as that in the 145 tissue sections. The potential role of the OKT9 antibody in both the screening of cervical cytocentrifuge preparations and the prediction of malignancy is discussed. The antibody is considered to be of more value in the examination of biopsy material than of cytocentrifuge preparations.<\/jats:p>","DOI":"10.1136\/jcp.37.2.131","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"131-135","source":"Crossref","is-referenced-by-count":40,"title":["Demonstration of an epitope of the transferrin receptor in human cervical epithelium--a potentially useful cell marker."],"prefix":"10.1136","volume":"37","author":[{"given":"J M","family":"Lloyd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"O'Dowd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Driver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D E","family":"Tee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0143-4004(80)80014-2","article-title":"Immunological studies of transferrin and transferrin receptor of human placenta trophoblast","volume":"1","author":"Galbraith, G.M.P.; Galbraith, R.M.; Faulk, W.P.","year":"1980","unstructured":"Galbraith GMP, Galbraith RM, Faulk WP. Immunological studies of transferrin and transferrin receptor of human placenta trophoblast. Placenta 1980;1:33-46.","journal-title":"Placenta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1073\/pnas.78.7.4222","article-title":"Radioimmunochemical measurement of the transferrin receptor in human trophoblast and reticulocyte membranes with a specific anti-receptor antibody","volume":"78","author":"Enns, C.A.; Shindelman, J.E.; Tonik, S.E.; Sussman, H.H.","year":"1981","unstructured":"Enns CA, Shindelman JE, Tonik SE, Sussman HH. Radioimmunochemical measurement of the transferrin receptor in human trophoblast and reticulocyte membranes with a specific anti-receptor antibody. Proc Natl Acad Sci USA 1981;78:4222-5.","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref_3","first-page":"6406","article-title":"Identification of transferrin receptors on the surface","volume-title":"of human cultured cells. 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Proc Natl Acad Sci USA 1981;78:3039-43.","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0140-6736(80)90440-7","article-title":"Transferrin and transferrin receptors in carcinoma of the breast","volume":"ii:","author":"Faulk, W.P.; Hsi, B.L.; Stevens, P.J.","year":"1980","unstructured":"Faulk WP, Hsi BL, Stevens PJ. Transferrin and transferrin receptors in carcinoma of the breast. Lancet 1980;ii:390-2.","journal-title":"Lancet"},{"key":"ref_6","first-page":"\"1301","article-title":"Demonstration of the transferrin receptor in human breast cancer tissue. Potential marker for identifying dividing cells","volume":"44","author":"Shindelman, J.E.; Ortmeyer, A.E.; Sussman, H.H.","year":"1981","unstructured":"Shindelman JE, Ortmeyer AE, Sussman HH. Demonstration of the transferrin receptor in human breast cancer tissue. Potential marker for identifying dividing cells. Int J Cancer 1981;44: 1301-10. '\u00b0 Trowbridge IS, Domingo DL. Anti-transferrin receptor monoclonal antibody and toxin antibody conjugates affect growth of human tumour cells. Nature 1981;294:171-3.","journal-title":"Int J Cancer; Trowbridge IS, Domingo DL. Anti-transferrin receptor monoclonal antibody and toxin antibody conjugates affect growth of human tumour cells"},{"key":"ref_7","first-page":"465","article-title":"NG ABP, Nordqvist SRB, Leif RC. Cervical carcinoma antigens in the diagnosis of human squamous cell carcinoma of the cervix","volume":"66","author":"Haines, H.G.; McCoy, J.P.; Hofheinz, D.E.","year":"1981","unstructured":"Haines HG, McCoy JP, Hofheinz DE, NG ABP, Nordqvist SRB, Leif RC. Cervical carcinoma antigens in the diagnosis of human squamous cell carcinoma of the cervix. J Natl Cancer Inst 1981;66:465-74.","journal-title":"J Natl Cancer Inst"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/jcp.36.5.539","article-title":"Transferrin receptors in human tissues; their distribution and possible clinical relevance","volume":"36","author":"Gatter, K.C.; Brown, G.; Trowbridge, I.S.; Woolston, R.E.; Mason, D.Y.","year":"1983","unstructured":"Gatter KC, Brown G, Trowbridge IS, Woolston RE, Mason DY. Transferrin receptors in human tissues; their distribution and possible clinical relevance. J Clin Pathol 1983;36:539-45.","journal-title":"J Clin Pathol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/jcp.37.1.14","article-title":"Immunohistochemical detection of Ca antigen in normal, dysplastic and neoplastic squamous epithelia of the human uterine cervix","volume":"37","author":"Lloyd, J.M.; Dowd, O.'; T, Driver; M, Tee; D.E.H.","year":"1984","unstructured":"Lloyd JM, O' Dowd T, Driver M, Tee DEH. Immunohistochemical detection of Ca antigen in normal, dysplastic and neoplastic squamous epithelia of the human uterine cervix. J Clin Pathol 1984;37:14-20.","journal-title":"J Clin Pathol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.37.2.131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:08:06Z","timestamp":1765692486000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.37.2.131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,2]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1984,2,1]]},"published-print":{"date-parts":[[1984,2]]}},"alternative-id":["10.1136\/jcp.37.2.131"],"URL":"https:\/\/doi.org\/10.1136\/jcp.37.2.131","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,2]]}}}