{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T02:29:41Z","timestamp":1764988181085,"version":"3.46.0"},"reference-count":11,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:p>A sequential series of 100 small bowel mucosal biopsies from children was studied to assess the frequency and pattern of mucosal fat staining, and to compare patterns of fat distribution with mucosal structure and clinical diagnosis. Deep mucosal fat was commonly associated with those clinical groups showing normal mucosal structure. While fine granular surface epithelial fat was common in normal and abnormal biopsies, the presence of large fat globules in the surface epithelium was almost entirely limited to biopsies showing villous shortening. Large fat globules in the surface epithelium in coeliac disease and cow's milk sensitive enteropathy were probably related to the more severe degrees of villous abnormality encountered in these clinical groups. However, large fat globules in surface epithelium were also found in a few cases of cow's milk sensitive enteropathy with normal or minimal villous blunting. Fat staining may be a useful additional histological marker to aid in the interpretation of small intestinal mucosal biopsies.<\/jats:p>","DOI":"10.1136\/jcp.37.4.373","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"373-377","source":"Crossref","is-referenced-by-count":26,"title":["Small intestinal mucosal fat in childhood enteropathies."],"prefix":"10.1136","volume":"37","author":[{"given":"S","family":"Variend","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Placzek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Raafat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Walker-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/gut.17.2.158","article-title":"Paediatric small intestinal biopsy capsule with two ports","volume":"17","author":"Kilby, A.","year":"1976","unstructured":"Kilby A. Paediatric small intestinal biopsy capsule with two ports. Gut 1976;17:158-9.","journal-title":"Gut"},{"key":"ref_2","first-page":"44","article-title":"Microvillous surface area in secondary disaccharidase deficiency","volume-title":"Gut","volume":"21","author":"Phillips, A.D.; Avigod, S.; Sacks, J.; Rice, S.J.; France, N.E.; WalkerSmith, J.A.","year":"1980","unstructured":"Phillips AD, Avigod S, Sacks J, Rice SJ, France NE, WalkerSmith JA. Microvillous surface area in secondary disaccharidase deficiency. Gut 1980;21:44-8."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1136\/bmj.1.6024.1501","article-title":"Cows' milk protein intolerance: A possible association with gastroenteritis, lactose intolerance, and IgA deficiency","volume":"i:","author":"Harrison, M.; Kilby, A.; Walker-Smith, J.A.","year":"1976","unstructured":"Harrison M, Kilby A, Walker-Smith JA. Cows' milk protein intolerance: A possible association with gastroenteritis, lactose intolerance, and IgA deficiency. Br Med J 1976;i: 1501-4.","journal-title":"Br Med J"},{"issue":"21 1","key":"ref_4","article-title":"Patchy enteropathy in childhood","volume-title":"Gut","volume":"20","author":"Manuel, P.D.; Walker-Smith, J.A.; France, N.E.","year":"1979","unstructured":"Manuel PD, Walker-Smith JA, France NE. Patchy enteropathy in childhood. Gut 1979;20:21 1."},{"key":"ref_5","first-page":"461","article-title":"Diagnostic criteria in coeliac disease","volume":"59","author":"Meeuwisse, G.W.","year":"1970","unstructured":"Meeuwisse GW. Diagnostic criteria in coeliac disease. Acta Paediatr Scand 1970;59:461-3.","journal-title":"Acta Paediatr Scand"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/adc.55.5.329","article-title":"Toddler's diarrhoea","volume":"55","author":"Walker-Smith, J.A.","year":"1980","unstructured":"Walker-Smith JA. Toddler's diarrhoea. Arch Dis Childh 1980;55:329.","journal-title":"Arch Dis Childh"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.5.3.373","article-title":"An electron microscopic study of the intestinal vilius. II. The pathway of fat absorption","volume":"5","author":"Palay, S.L.; Karlin, L.J.","year":"1959","unstructured":"Palay SL, Karlin LJ. An electron microscopic study of the intestinal vilius. II. The pathway of fat absorption. Biophys Biochem Cytol 1959;5:373-83.","journal-title":"Biophys Biochem Cytol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0022-2275(20)40290-1","article-title":"The intestinal absorption of fatty acid: A biochemical and elctron microscopic study","volume":"4","author":"Ashworth, C.T.; Johnston, J.M.","year":"1963","unstructured":"Ashworth CT, Johnston JM. The intestinal absorption of fatty acid: A biochemical and elctron microscopic study. J Lip Res 1963;4:454-60.","journal-title":"J Lip Res"},{"key":"ref_9","first-page":"\"389","article-title":"A morphological study of fat transport in the normal human jejunum","volume":"112","author":"Ladman, A.J.; Padykula, H.A.; Strauss, E.W.","year":"1963","unstructured":"Ladman AJ, Padykula HA, Strauss EW. A morphological study of fat transport in the normal human jejunum. Am J Anat 1963;112:389-425. '\u00b0 Booth CC. Enterocyte in coeliac disease. Br Med J 1970;iii:725-31.","journal-title":"Am J Anat; Booth CC. Enterocyte in coeliac disease"},{"key":"ref_10","first-page":"1041","article-title":"Quantitative analysis of small intestinal mucosa in cows' milk sensitive enteropathy","volume":"12","author":"Maluenda, C.; Phillips, A.D.; Briddon, A.; Walker-Smith, J.A.","year":"1980","unstructured":"Maluenda C, Phillips AD, Briddon A, Walker-Smith JA. Quantitative analysis of small intestinal mucosa in cows' milk sensitive enteropathy. J Ped Gastroenterol Nutr (in press) 12 Kosnai I, Kuitunen P, Savilakti E, Rapola J, Kohegyi J. Cell kinetics in the jejunal crypt epithelium in malabsorption syndrome with cows' milk protein intolerance and coeliac disease of childhood. Gut 1980;21:1041-6.","journal-title":"J Ped Gastroenterol Nutr; Cell kinetics in the jejunal crypt epithelium in malabsorption syndrome with cows' milk protein intolerance and coeliac disease of childhood"},{"key":"ref_11","first-page":"277","article-title":"Congenital absence of beta-lipoprotein","volume":"32","author":"Lamy, M.; Frezal, J.; Polonovski, J.; Druez, G.; Rey, J.","year":"1963","unstructured":"Lamy M, Frezal J, Polonovski J, Druez G, Rey J. Congenital absence of beta-lipoprotein. 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