{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:43:17Z","timestamp":1765082597401,"version":"3.46.0"},"reference-count":11,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1984,9]]},"abstract":"<jats:p>The usefulness of serial study of C reactive protein in the early detection of neonatal septicaemia was evaluated in a neonatal unit using a commercially available latex agglutination slide test as a rapid screening method and electroimmunoassay as a reference method for C reactive protein determination. A positive latex test was obtained in 11 infants with verified septicaemia (positive blood culture), two infants with clinically evident infection but without bacteriological confirmation, one infant with recurrent chest infection due to Pseudomonas aeruginosa, and one infant who showed signs of birth asphyxia with meconium aspiration, but was not infected. Positive latex test results correlated with raised concentrations of C reactive protein, measured by immunoassay. In some instances, however, concentrations of C reactive protein in excess of 12 mg\/100 ml gave weaker agglutination results in the slide test, which could be interpreted as negative results. In a sequential study of the infected infants, 6.3% of the values recorded on a slide test were false negatives. In contrast, false positive values were observed on a slide test in 1.9% of 27 non-infected infants. The higher percentage of false negative values may be due to the presence of excess antigen in the sera of some infected children. It is suggested that the latex test should be carried out on suitable dilutions of serum. Although the slide test may reliably indicate infection at an early stage in neonates, the C reactive protein response is non-specific, as seen in a non-infected infant who showed signs of birth asphyxia with meconium aspiration. Provided the non-specific nature of the C reactive protein response is recognised, the latex test may be a useful serum measurement for early diagnosis of neonatal septicaemia of the newborn. The test has the advantage of being performed easily, quickly, and cheaply.<\/jats:p>","DOI":"10.1136\/jcp.37.9.1014","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1014-1017","source":"Crossref","is-referenced-by-count":7,"title":["Sequential study of C reactive protein in neonatal septicaemia using a latex agglutination test."],"prefix":"10.1136","volume":"37","author":[{"given":"P","family":"Hindocha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Gould","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Wojciechowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C B","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1651-2227.1979.tb08219.x","article-title":"C-reactive protein (CRP) in early diagnosis of neonatal septicaemia","volume":"68","author":"Sabel, K.G.; Wadsworth, C.H.","year":"1979","unstructured":"Sabel KG, Wadsworth CH. C-reactive protein (CRP) in early diagnosis of neonatal septicaemia. Acta Paediatr Scand 1979;68:825-31.","journal-title":"Acta Paediatr Scand"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1542\/peds.65.5.1036","article-title":"Early diagnosis of neonatal sepsis","volume":"65","author":"Philip, A.G.S.; Hewitt, JR","year":"1980","unstructured":"Philip AGS, Hewitt JR. Early diagnosis of neonatal sepsis. Paediatrics 1980;65: 1036-41.","journal-title":"Paediatrics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1651-2227.1983.tb09793.x","article-title":"Sequential determination of CRP, a,-antitrypsin and haptoglobin in neonatal septicaemia","volume":"72","author":"Speer, C.H.; Bruns, A.; Gahr, M.","year":"1983","unstructured":"Speer CH, Bruns A, Gahr M. Sequential determination of CRP, a,-antitrypsin and haptoglobin in neonatal septicaemia. Acta Paediatr Scand 1983;72:679-83.","journal-title":"Acta Paediatr Scand"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0022-3476(82)80080-2","article-title":"C-reactive protein and problems of newborn infants","volume":"101","year":"1982","unstructured":"C-reactive protein and problems of newborn infants. J Pediatr 1982; 101:438-40.","journal-title":"J Pediatr"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/adc.59.5.435","article-title":"Serial study of C-reactive protein in neonatal septicaemia","volume":"59","author":"Hindocha, P.; Campbell, C.A.; Gould, J.D.M.; Wojciechowski, A.; Wood, C.B.S.","year":"1984","unstructured":"Hindocha P, Campbell CA, Gould JDM, Wojciechowski A, Wood CBS. Serial study of C-reactive protein in neonatal septicaemia. 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Pediatr Res 1973;7:403.","journal-title":"Pediatr Res"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0022-3476(83)80241-8","article-title":"Cerebrospinal fluid CRP in neonatal meningitis","volume":"5","author":"Philip, A.G.S.; Baker, C.J.","year":"1983","unstructured":"Philip AGS, Baker CJ. Cerebrospinal fluid CRP in neonatal meningitis. J Paediatr 1983; 5:715-7.","journal-title":"J Paediatr"},{"key":"ref_11","first-page":"304","article-title":"Laser nephelometer and latex determinations of acute phase proteins in neonatal sepsis (abst)","volume":"16","author":"Philip, A.G.S.; Tucker, R.","year":"1982","unstructured":"Philip AGS, Tucker R. Laser nephelometer and latex determinations of acute phase proteins in neonatal sepsis (abst). Pediatr Res 1982; 16:304A.","journal-title":"Pediatr Res"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.37.9.1014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:22:33Z","timestamp":1765077753000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.37.9.1014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9]]},"references-count":11,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1984,9,1]]},"published-print":{"date-parts":[[1984,9]]}},"alternative-id":["10.1136\/jcp.37.9.1014"],"URL":"https:\/\/doi.org\/10.1136\/jcp.37.9.1014","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1984,9]]}}}