{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:55:50Z","timestamp":1765709750417,"version":"3.48.0"},"reference-count":5,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1985,10]]},"abstract":"<jats:p>Fourteen adults with idiopathic thrombocytopenic purpura suffered a relapse after treatment with steroids, vinca alkaloids, or intravenous gammaglobulin. Splenic sequestration of platelets labelled with 111In-oxine was assessed, and the patients then underwent splenectomy. During follow up of four to 47 months (mean 20.7) none of the patients required further treatment, including three of 14 who showed partial relapses. Splenic sequestration patterns did not predict relapses, but an unexpected finding was that patients who relapsed had significantly smaller spleens. It is concluded that splenectomy is beneficial in most adult patients with idiopathic thrombocytopenic purpura and that radiological techniques to measure the size of the spleen may be useful in predicting which patients may relapse.<\/jats:p>","DOI":"10.1136\/jcp.38.10.1172","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1172-1174","source":"Crossref","is-referenced-by-count":4,"title":["Size of spleen rather than amount of platelet sequestration may determine long term responses to splenectomy in adult idiopathic thrombocytopenic purpura."],"prefix":"10.1136","volume":"38","author":[{"given":"B J","family":"Boughton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Fielding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Hawker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Chandler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Howie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJM198105073041904","article-title":"Chronic idiopathic thrombocytopenic purpura","volume":"304","author":"McMillan, R.","year":"1981","unstructured":"McMillan R. Chronic idiopathic thrombocytopenic purpura. N Engl J Med 1981;304:1135-47.","journal-title":"N Engl J Med"},{"key":"ref_2","first-page":"351","article-title":"Subcellular localization of \"I'","volume-title":"in human and rabbit platelets. Blood","volume":"59","author":"Baker, J.R.J.; Butler, K.D.; Eakins, M.N.; Pay, G.F.; White, A.M.","year":"1982","unstructured":"Baker JRJ, Butler KD, Eakins MN, Pay GF, White AM. Subcellular localization of \"I' In in human and rabbit platelets. Blood 1982;59:351-9."},{"issue":"241","key":"ref_3","first-page":"9","article-title":"Platelet turnover; an important factor in predicting the response to splenectomy in autoimmune thrombocytopenic purpura","volume":"64","author":"Siegel, R.S.; Coleman, R.E.; Kurlander, R.; Rosse, W.F.","year":"1984","unstructured":"Siegel RS, Coleman RE, Kurlander R, Rosse WF. Platelet turnover; an important factor in predicting the response to splenectomy in autoimmune thrombocytopenic purpura. Blood 1984;64:241a 9 Hawker RJ, Hawker LM, Wilkinson AR. Indium (111-In) labelled human platelets: optimal method. Clin Sci 1980;58:243-8. '0 Walker W. Splenectomy in childhood: a review in England and Wales 1960-4. Br J Surg 1976;63:36-43.","journal-title":"Blood; Indium (111-In) labelled human platelets: optimal method"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"194","DOI":"10.7326\/0003-4819-86-2-194","article-title":"Platelet kinetics in autoimmune thrombocytopenia: relation between splenic sequestration and response to splenectomy","volume":"86","author":"Ries, C.A.","year":"1977","unstructured":"Ries CA. Platelet kinetics in autoimmune thrombocytopenia: relation between splenic sequestration and response to splenectomy. Ann Intern Med 1977;86:194-5.","journal-title":"Ann Intern Med"},{"key":"ref_5","first-page":"309","article-title":"Accessory splenic tissue in a patient with relapsed thrombocytopenic purpura","volume":"4","author":"Sweeney, J.D.; Keane, F.B.; Freyne, P.J.; Temperley, I.J.; McCann, SR","year":"1982","unstructured":"Sweeney JD, Keane FB, Freyne PJ, Temperley IJ, McCann SR. Accessory splenic tissue in a patient with relapsed thrombocytopenic purpura. Clin Lab Haematol 1982;4:309-12.","journal-title":"Clin Lab Haematol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.38.10.1172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:53:27Z","timestamp":1765709607000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.38.10.1172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,10]]},"references-count":5,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1985,10,1]]},"published-print":{"date-parts":[[1985,10]]}},"alternative-id":["10.1136\/jcp.38.10.1172"],"URL":"https:\/\/doi.org\/10.1136\/jcp.38.10.1172","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1985,10]]}}}