{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:19:02Z","timestamp":1764994742015,"version":"3.46.0"},"reference-count":26,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:p>In a retrospective study of 111 patients with aplastic anaemia iliac crest biopsies were evaluated for the presence of morphological features statistically related to the evolution of the disease. Prognostic variables for a transition to acute non-lymphatic leukaemia were: cellular atypias of the three haemopoietic lineages, as observed in the myelodysplastic syndrome, and especially \"micromegakaryocytes\"; high numbers or irregular distribution of megakaryocytes, or both; and (slight) marrow fibrosis. Clinical variables did not influence these prognostic correlations. Prognosis in relation to death from bone marrow failure without leukaemia might well have been influenced by a strong plasma cell reaction, but this correlation was weakened by clinical factors. On the basis of this study aplastic anaemia can thus be subdivided morphologically into two disease entities--namely, hypocellular myelodysplastic syndrome with a 23-82% risk of acute non-lymphatic leukaemia developing within three years, depending on how many variables associated with acute non-lymphatic leukaemia are present, and non-dysplastic myelohypoplasia.<\/jats:p>","DOI":"10.1136\/jcp.38.11.1218","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1218-1224","source":"Crossref","is-referenced-by-count":83,"title":["Aplastic anaemia and the hypocellular myelodysplastic syndrome: histomorphological, diagnostic, and prognostic features."],"prefix":"10.1136","volume":"38","author":[{"given":"I","family":"Fohlmeister","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"M\u00f6dder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Rister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H E","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1182\/blood.V30.2.251.251","article-title":"Riddle: what do aplastic anemia, paroxysmal nocturnal hemoglobinuria (PNH) and 'hypoplastic\" leukemia have in common?","volume":"30","author":"Dameshek, W.","year":"1967","unstructured":"Dameshek W. 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Blood and bone marrow foilow-up studies on patients with preleukemic states-observation of different phases of the evolving leukemic process. In: Schmalzl F, Hellriegel KP, eds. Preleukemia. Berlin: Springer Verlag, 1979:16-22."},{"key":"ref_8","first-page":"\"91","article-title":"Pathogenetic relationship between hypoplastic myelopathy and preleukemic syndrome","volume":"30","author":"Fischer, R.; Fohlmeister, I.; Schaefer, H.E.","year":"1984","unstructured":"Fischer R, Fohlmeister I, Schaefer HE. Pathogenetic relationship between hypoplastic myelopathy and preleukemic syndrome. In: Lennert K, ed. Histopathology of the bone marrow. Stuttgart: G Fischer, 1984:91-6. '\u00b0 Krauze-Jaworska H, Polowska-Kulesza E, Krykowski E. Preleukemic conditions presenting as failure of bone marrow tissue. 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