{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:10:30Z","timestamp":1771002630069,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1985,2]]},"abstract":"<jats:p>The survival of red cells labelled with indium-111 oxine in the circulation was determined. In vivo distribution at equilibrium and sites of deposition at the T50In--that is, the half life of labelled red cells--were quantitated with a scintillation camera and computer assisted image analysis. Although the rate of elution. Of 111In from the red cells was higher than that of chromium-51-disodium chromate, estimates of T50In and T50Cr corresponded reasonably well and were shortened in haemolytic anaemia. In normal subjects red cells were sequestered mainly in the liver and spleen. In five patients with different types of haemolytic anaemia two distinct patterns of red cell sequestration could be recognised: mainly splenic sequestration, and destruction of red cells in the liver, spleen, and the bone marrow. These patterns were expected for the particular disease studied.<\/jats:p>","DOI":"10.1136\/jcp.38.2.128","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"128-132","source":"Crossref","is-referenced-by-count":10,"title":["Kinetics, distribution, and sites of destruction of indium-111 oxine labelled red cells in haemolytic anaemia."],"prefix":"10.1136","volume":"38","author":[{"given":"A D","family":"Heyns","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G","family":"L\u00f6tter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H F","family":"Kotz\u00e8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Wessels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P N","family":"Badenhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2141.1971.tb03435.x","article-title":"ICSH Panel on Diagnostic Application of Radioisotopes in Haematology. Recommended methods for radioisotope redcell survival studies","volume":"21","year":"1971","unstructured":"ICSH Panel on Diagnostic Application of Radioisotopes in Haematology. Recommended methods for radioisotope redcell survival studies. Br J Haematol 1971; 21: 241-50.","journal-title":"Br J Haematol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2141.1975.tb00538.x","article-title":"ICSH Panel on Diagnostic Application of Radioisotopes in Haematology. Recommended methods for surface counting to determine sites of red-cell destruction","volume":"30","year":"1975","unstructured":"ICSH Panel on Diagnostic Application of Radioisotopes in Haematology. Recommended methods for surface counting to determine sites of red-cell destruction. Br J Haematol 1975;30:249-54.","journal-title":"Br J Haematol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0001-2998(75)80004-3","article-title":"Studies of the erythron","volume":"5","author":"Pollycove, M.; Tono, M.","year":"1975","unstructured":"Pollycove M, Tono M. Studies of the erythron. Semin Nucl Med 1975;5: 11-61.","journal-title":"Semin Nucl Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0049-3848(76)90135-3","article-title":"Indium-111 labelled platelets: Studies on preparation and evaluation of in vivo and in vitro functions","volume":"9","author":"Thakur, M.L.; Welch, M.J.; Joist, J.H.; Coleman, R.E.","year":"1976","unstructured":"Thakur ML, Welch MJ, Joist JH, Coleman RE. Indium-111 labelled platelets: Studies on preparation and evaluation of in vivo and in vitro functions. Thromb Res 1976;9:345-57.","journal-title":"Thromb Res"},{"key":"ref_5","first-page":"278","article-title":"Red cell membrane permeability and metal oxine-haemoglobin transchelation; implications in cell labeling","volume":"XVEI:","author":"Dewanjee, M.K.; Rao, S.A.","year":"1972","unstructured":"Dewanjee MK, Rao SA. Red cell membrane permeability and metal oxine-haemoglobin transchelation; implications in cell labeling. Journal of Labelled Compounds and Radiopharmaceuticals 1972;XVEI:278.","journal-title":"Journal of Labelled Compounds and Radiopharmaceuticals"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2141.1980.tb01209.x","article-title":"distribution and sites of destruction of Indium-ill-labelled human platelets","volume":"44","author":"du P, Heyns A.; MG, LUtter; PN, Badenhorst","year":"1980","unstructured":"Heyns A du P, LUtter MG, Badenhorst PN, et al. Kinetics, distribution and sites of destruction of Indium-ill-labelled human platelets. Br J Haematol 1980;44:269-80.","journal-title":"Br J Haematol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1001\/archsurg.1982.01380330032009","article-title":"and fate of Indium-1 11-oxine labeled platelets in patients with aortic aneurysms","volume":"117","author":"du P, Heyns A.; MG, Lotter; PN, Badenhorst; H, Pieters; CJC, Nel; Kinetics, Minnaar P.C.","year":"1982","unstructured":"Heyns A du P, Lotter MG, Badenhorst PN, Pieters H, Nel CJC, Minnaar PC. Kinetics, and fate of Indium-1 11-oxine labeled platelets in patients with aortic aneurysms. Arch Surg 1982; 117: 1170-4.","journal-title":"Arch Surg"},{"key":"ref_8","first-page":"174","article-title":"A quantitative study of indium-111-oxine platelet kinetics in acute and chronic renal transplant rejection","volume":"18","author":"du P, Heyns A.; MG, L6tter; H, Pieters","year":"1982","unstructured":"Heyns A du P, L6tter MG, Pieters H, et al. A quantitative study of indium-111-oxine platelet kinetics in acute and chronic renal transplant rejection. Clin Nephrol 1982; 18: 174-82.","journal-title":"Clin Nephrol"},{"key":"ref_9","first-page":"\"507","article-title":"Elution of In-Ill from reticuloendothelial cells","volume":"32","author":"Peters, A.M.; Klonizakis, I.; Lavender, J.P.; Lewis, S.M.","year":"1982","unstructured":"Peters AM, Klonizakis I, Lavender JP, Lewis SM. Elution of In-Ill from reticuloendothelial cells. J Clin Pathol 1982;32:507-9. I0 Van Reenen OR, LUtter MG, Heyns A du P, et al. Quantification of the distribution of In-1I-labelled platelets in organs. Eur J Nucl Med 1982;7:80-4. \"Heyns A du P, Lotter MG, Kotze HF, Pieters H, Wessels P. Quantification of in vivo distribution of platelets labelled with indium-I 11-oxine.J Nuci Med 1982;23:943-4.","journal-title":"J Clin Pathol; Quantification of the distribution of In-1I-labelled platelets in organs"},{"key":"ref_10","first-page":"7905","article-title":"Radiation dose from human platelets labelled with indium-I1 1","volume":"53","author":"OR, Van Reenen; MG, LUtter; PC, Minnaar; du P, Heyns A.; PN, Badenhorst; H, Pieters","year":"1980","unstructured":"Van Reenen OR, LUtter MG, Minnaar PC, Heyns A du P, Badenhorst PN, Pieters H. Radiation dose from human platelets labelled with indium-I1 1. Br J Radiol 1980;53:7905.","journal-title":"Br J Radiol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1148\/radiology.140.1.7244222","article-title":"Distribution and dosimetry of In-111-labelled platelets","volume":"140","author":"Robertson, J.S.; Dewanjee, M.K.; Brown, M.L.; Fuster, V.; Chesebro, J.H.","year":"1981","unstructured":"Robertson JS, Dewanjee MK, Brown ML, Fuster V, Chesebro JH. Distribution and dosimetry of In-111-labelled platelets. Radiology 1981; 140: 169-76.","journal-title":"Radiology"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.38.2.128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:45:36Z","timestamp":1758800736000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.38.2.128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1985,2,1]]},"published-print":{"date-parts":[[1985,2]]}},"alternative-id":["10.1136\/jcp.38.2.128"],"URL":"https:\/\/doi.org\/10.1136\/jcp.38.2.128","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,2]]}}}