{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:34:23Z","timestamp":1774452863009,"version":"3.50.1"},"reference-count":6,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:p>We have found glomerular capillary thrombi or afferent arteriolar thrombosis in eight renal biopsy specimens from seven renal allograft recipients. All patients were receiving cyclosporin and prednisolone. Biopsies were performed either routinely one and four weeks after transplantation or during periods of renal dysfunction. None of the patients whose biopsy material contained glomerular thrombi was considered, in retrospect, to have been undergoing rejection at the time of biopsy. Thrombi consisted of finely granular material partially obstructing glomerular capillaries. By light microscopy the staining characteristics of the thrombi were compatible with platelet-fibrin aggregates, and this was confirmed by immunoperoxidase examination. Such thrombi have not previously been seen in biopsy material from patients treated with prednisolone and azathioprine, except rarely associated with acute vascular injection. In none of these patients was there haematological evidence of the haemolytic uraemic syndrome as has been reported in bone marrow recipients treated with cyclosporin.<\/jats:p>","DOI":"10.1136\/jcp.38.3.253","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"253-258","source":"Crossref","is-referenced-by-count":84,"title":["Glomerular thrombi in renal allografts associated with cyclosporin treatment."],"prefix":"10.1136","volume":"38","author":[{"given":"G H","family":"Neild","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Reuben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R B","family":"Hartley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2141.1983.tb02067.x","article-title":"Cyclosporin A associated nephrotoxicity in the first 100 days after allogeneic bone marrow transplantation: three distinct syndromes","volume":"54","author":"Atkinson, K.; Biggs, J.C.; Hayes, J.; Ralston, M.; Dodds, A.J.","year":"1983","unstructured":"Atkinson K, Biggs JC, Hayes J, Ralston M, Dodds AJ. Cyclosporin A associated nephrotoxicity in the first 100 days after allogeneic bone marrow transplantation: three distinct syndromes. Br J Haematol 1983;54:59-67.","journal-title":"Br J Haematol"},{"key":"ref_2","first-page":"133","article-title":"Glomerular thrombosis and cortical infarction in cyclosporin-treated rabbits with acute serum sickness","volume":"65","author":"Neild, G.H.; Ivory, K.; Williams, D.G.","year":"1984","unstructured":"Neild GH, Ivory K, Williams DG. Glomerular thrombosis and cortical infarction in cyclosporin-treated rabbits with acute serum sickness. Br J Exp Pathol 1984;65:133-44.","journal-title":"Br J Exp Pathol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00005792-197101000-00002","article-title":"Human renal allografts. The role of vascular injury in early graft failure","volume":"50","author":"Busch, G.J.; Reynolds, E.S.; Galvanek, E.G.; Braun, W.E.; Dammin, G.J.","year":"1971","unstructured":"Busch GJ, Reynolds ES, Galvanek EG, Braun WE, Dammin GJ. Human renal allografts. The role of vascular injury in early graft failure. Medicine 1971;50:29-79.","journal-title":"Medicine"},{"key":"ref_4","first-page":"1323","article-title":"Cyclosporin A in patients receiving renal allografts from cadaver donors","volume":"ii:","author":"Caine, R.Y.; White, D.J.G.; Thiru, S.","year":"1978","unstructured":"Caine RY, White DJG, Thiru S, et al. Cyclosporin A in patients receiving renal allografts from cadaver donors. Lancet 1978;ii: 1323-7.","journal-title":"Lancet"},{"key":"ref_5","first-page":"871","article-title":"Haemolytic uraemic syndrome: deficiency of plasma factor(s) regulating prostacyclin activity","volume":"1978","author":"Remuzzi, G.; Misiani, R.; Marchesi, D.","unstructured":"Remuzzi G, Misiani R, Marchesi D, et al. Haemolytic uraemic syndrome: deficiency of plasma factor(s) regulating prostacyclin activity. Lancet 1978:ii:871-2.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0090-6980(82)90129-0","article-title":"In vitro prostaglandin synthesis by human glomeruli and papillae","volume":"23","author":"Sraer, J.; Ardaillou, N.; Sraer, J.D.; Ardaillou, R.","year":"1982","unstructured":"Sraer J, Ardaillou N, Sraer JD, Ardaillou R. In vitro prostaglandin synthesis by human glomeruli and papillae. Prostaglandins 1982;23:855-64.","journal-title":"Prostaglandins"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.38.3.253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:28:01Z","timestamp":1765009681000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.38.3.253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1985,3,1]]},"published-print":{"date-parts":[[1985,3]]}},"alternative-id":["10.1136\/jcp.38.3.253"],"URL":"https:\/\/doi.org\/10.1136\/jcp.38.3.253","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}