{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:04:13Z","timestamp":1762160653033,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:p>We report a case of non-sideroblastic refractory anaemia which evolved to a double lymphomyeloproliferative disorder. At presentation, bone marrow appearances and peripheral blood pancytopenia without myelomonocytosis were consistent with a diagnosis of non-sideroblastic refractory anaemia. Subsequently, the patient developed pronounced myelomonocytosis and lymphocytosis with prolymphocytes. Light and transmission electron microscopy as well as surface marker studies were compatible with a diagnosis of prolymphocytic transformation of chronic lymphocytic leukaemia\/prolymphocytic leukaemia associated with myelomonocytic leukaemia. The pathogenesis of such double lympho-myeloproliferative disorders is discussed in the light of the evidence for common lymphoid and myeloid progenitor cells and some recent advances in the immunology of the myelodysplastic syndromes.<\/jats:p>","DOI":"10.1136\/jcp.38.3.297","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"297-300","source":"Crossref","is-referenced-by-count":13,"title":["Refractory anaemia terminating in a combined lymphoproliferative and myeloproliferative disorder."],"prefix":"10.1136","volume":"38","author":[{"given":"L","family":"Camba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M V","family":"Joyner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"Proposal for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennett, J.M.; Gatovsky, D.; etal, Daniel M.T.","year":"1982","unstructured":"Bennett JM, Gatovsky D, Daniel MT etal. Proposal for the classification of the myelodysplastic syndromes. Br J Haematol 1982;51: 189-99.","journal-title":"Br J Haematol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1182\/blood.V63.2.314.314","article-title":"Refractory dysmyelopoietic anaemia and leukaemia","volume":"63","author":"Rosenthal, D.S.; Maloney, W.C.","year":"1984","unstructured":"Rosenthal DS, Maloney WC. Refractory dysmyelopoietic anaemia and leukaemia. Blood 1984;63:314-8.","journal-title":"Blood"},{"key":"ref_3","first-page":"85","article-title":"Refractory sideroblastic and nonsideroblastic anaemia. A review of 27 cases","volume":"127","author":"Geschke, W.; Beutler, E.","year":"1977","unstructured":"Geschke W, Beutler E. Refractory sideroblastic and nonsideroblastic anaemia. A review of 27 cases. West J Med 1977; 127:85-92.","journal-title":"West J Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2141.1982.tb01890.x","article-title":"Quantitative evaluation of erythropoietic activity in dysmyelopoietic syndromes","volume":"50","author":"Cazzola, M.; Barosi, G.; Berzuini, C.","year":"1982","unstructured":"Cazzola M, Barosi G, Berzuini C, et al. Quantitative evaluation of erythropoietic activity in dysmyelopoietic syndromes. Br J Haematol 1982;50:55-62.","journal-title":"Br J Haematol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2141.1981.00111.x","article-title":"Simultaneous or spontaneous occurrence of lympho-and myeloproliferative disorders: a report of four cases","volume":"48","author":"Manoharan, A.; Catovsky, D.; Clein, P.","year":"1981","unstructured":"Manoharan A, Catovsky D, Clein P et al. 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