{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:29:17Z","timestamp":1765006157763,"version":"3.46.0"},"reference-count":21,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:p>Serum samples from 40 students with suspected infectious mononucleosis were tested for the presence of antibodies to intermediate filaments (AIFA) of the cytoskeleton. Twenty had antibodies to the Epstein-Barr virus capsid antigen before their illness, and during it their sera remained negative by the Paul-Bunnell test. The other 20 patients did not have antibodies to the Epstein-Barr virus capsid antigen before their illness and seroconverted during the illness. These patients (true infectious mononucleosis group) developed positive Paul-Bunnell tests. Sera from normal subjects (blood donors) were also tested for AIFA. AIFA was present in titres greater than 1\/10 in 80% of the infectious mononucleosis group (mean titre 1\/40-1\/80), 10% of the Paul-Bunnell negative glandular fever group, and 8.5% of the normal blood donors.<\/jats:p>","DOI":"10.1136\/jcp.38.3.351","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"351-354","source":"Crossref","is-referenced-by-count":2,"title":["Incidence of anti-intermediate filament antibody in serum samples of students with suspected glandular fever."],"prefix":"10.1136","volume":"38","author":[{"given":"P K","family":"Kataaha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E J","family":"Holborow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/ard.41.1.69","article-title":"Antibody to intermediate filaments of the cytoskeleton in rheumatoid arthritis","volume":"41","author":"Osung 0, Chandra M, Holborow EJ","year":"1982","unstructured":"Osung 0, Chandra M, Holborow EJ. Antibody to intermediate filaments of the cytoskeleton in rheumatoid arthritis. Ann Rheum Dis 1982;41:69-73.","journal-title":"Ann Rheum Dis"},{"key":"ref_2","first-page":"177","article-title":"Antibody to intermediate filaments of the cytoskeleton in the sera of patients with acute malaria. Clin Exp Immunol","volume":"55","author":"Mortazavi-Milani, S.M.; Holborow, E.J.","year":"1984","unstructured":"Mortazavi-Milani SM, Holborow EJ. Antibody to intermediate filaments of the cytoskeleton in the sera of patients with acute malaria. Clin Exp Immunol 1984;55: 177-82."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0090-1229(79)90093-X","article-title":"Autoantibody to \"intermediate filaments\" in infectious mononucleosis","volume":"14","author":"Linder, E.; Kurki, P.; Andersson, L.C.","year":"1979","unstructured":"Linder E, Kurki P, Andersson LC. Autoantibody to \"intermediate filaments\" in infectious mononucleosis. Clin Immunol Immunopathol 1979;14:411-7.","journal-title":"Clin Immunol Immunopathol"},{"key":"ref_4","first-page":"78","article-title":"Viral infections and IgM autoantibodies to cytoplasmic intermediate filaments. Clin Exp Immunol","volume":"37","author":"Toh, B.H.; Yildiz, A.; Sotelo, J.","year":"1979","unstructured":"Toh BH, Yildiz A, Sotelo J, et al. Viral infections and IgM autoantibodies to cytoplasmic intermediate filaments. Clin Exp Immunol 1979;37:78-82."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0090-1229(78)90165-4","article-title":"Characterization of human smooth muscle autoantibodies reacting with cytoplasmic intermediate filaments","volume":"11","author":"Kurki, P.; Virtanen, I.; Stenman, S.; Linder, E.","year":"1978","unstructured":"Kurki P, Virtanen I, Stenman S, Linder E. Characterization of human smooth muscle autoantibodies reacting with cytoplasmic intermediate filaments. Clin Immunol Immunopathol 1978; 11:379-87.","journal-title":"Clin Immunol Immunopathol"},{"key":"ref_6","first-page":"643","article-title":"A joint investigation by university health physicians and PHLS Laboratories","volume":"iv:","year":"1971","unstructured":"A joint investigation by university health physicians and PHLS Laboratories. Br Med J 1971;iv:643-6.","journal-title":"Br Med J"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1136\/jcp.29.9.841","article-title":"Measurement of heterophile antibody and antibodies to EB viral capsid antigen IgG and IgM in suspected cases of infectious mononucleosis","volume":"29","author":"Blake, J.M.; Edwards, J.M.B.; Fletcher, W.; McSwiggan, D.A.; Pereira, M.S.","year":"1976","unstructured":"Blake JM, Edwards JMB, Fletcher W, McSwiggan DA, Pereira MS. Measurement of heterophile antibody and antibodies to EB viral capsid antigen IgG and IgM in suspected cases of infectious mononucleosis. J Clin Pathol 1976;29:841.","journal-title":"J Clin Pathol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1073\/pnas.75.10.5034","article-title":"Different intermediate sized filaments distinguished by immunofluorescence microscopy","volume":"75","author":"Franke, W.W.; Schmid, E.; Osborn, M.; Weber, K.","year":"1978","unstructured":"Franke WW, Schmid E, Osborn M, Weber K. Different intermediate sized filaments distinguished by immunofluorescence microscopy. Proc Nad Acad Sci USA 1978;75:5034-8.","journal-title":"Proc Nad Acad Sci USA"},{"key":"ref_9","article-title":"Antinuclear factor and other antibodies in blood and liver diseases","volume":"656","author":"Holborow, E.J.; Asherson, G.C.; Johnson, G.D.; Barnes, R.D.S.; Carmichael, D.C.","year":"1963","unstructured":"Holborow EJ, Asherson GC, Johnson GD, Barnes RDS, Carmichael DC. Antinuclear factor and other antibodies in blood and liver diseases. Br Med J 1963;i:656.","journal-title":"Br Med J"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJM196601132740202","article-title":"Studies on the macroglobulins of human serum. I. Polyclonal immunoglobulin class M (IgM). Increases in infectious mononucleosis","volume":"274","author":"Wollheim, F.A.; Williams, R.C.","year":"1966","unstructured":"Wollheim FA, Williams RC. Studies on the macroglobulins of human serum. I. Polyclonal immunoglobulin class M (IgM). Increases in infectious mononucleosis. N Engl J Med 1966;274:61.","journal-title":"N Engl J Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/bmj.3.5875.323","article-title":"Smooth muscle antibodies in infectious mononucleosis","volume":"iii:","author":"Holborow, E.J.; Hemsted, E.H.; Mead, S.U.","year":"1973","unstructured":"Holborow EJ, Hemsted EH, Mead SU. Smooth muscle antibodies in infectious mononucleosis. Br Med J 1973;iii:323.","journal-title":"Br Med J"},{"key":"ref_12","first-page":"427","article-title":"The occurrence of autoantibodies in infectious mononucleosis","volume":"17","author":"Sutton, R.N.P.; Edmond, R.T.D.; Thomas, B.; Doniach, D.","year":"1974","unstructured":"Sutton RNP, Edmond RTD, Thomas B, Doniach D. The occurrence of autoantibodies in infectious mononucleosis. Clin Exp Immunol 1974;17:427-36.","journal-title":"Clin Exp Immunol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0165-2478(82)90135-3","article-title":"Holborow EJ. In vitro induction of anti-intermediate filament antibody in lymphocyte cultures by Epstein Barr virus","volume":"5","author":"Mortazavi-Milani, S.M.; Stierle, H.E.","year":"1982","unstructured":"Mortazavi-Milani SM, Stierle HE, Holborow EJ. In vitro induction of anti-intermediate filament antibody in lymphocyte cultures by Epstein Barr virus. Immunology Letters 1982;5:203-5.","journal-title":"Immunology Letters"},{"key":"ref_14","first-page":"129","article-title":"Analysis of polyclonal rheumatoid factors by isoelectric focusing","volume":"61","author":"Santana, R.; Stierle, H.E.; March, R.E.; Holborow, E.J.","year":"1983","unstructured":"Santana R, Stierle HE, March RE, Holborow EJ. Analysis of polyclonal rheumatoid factors by isoelectric focusing. J Imnunol Methods 1983;61:129-30.","journal-title":"J Imnunol Methods"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/292772a0","article-title":"Cross-reactivity between Thy-I and Component of intermediate filaments demonstrated using a monoclonal antibody","volume":"292","author":"Dulbecco, R.M.; Unger, M.; Bologna, M.","year":"1981","unstructured":"Dulbecco RM, Unger M, Bologna M, et al. Cross-reactivity between Thy-I and Component of intermediate filaments demonstrated using a monoclonal antibody. Nature 1981;292:772-4.","journal-title":"Nature"},{"key":"ref_16","first-page":"83","article-title":"Probing the function of the eukaryotic 5'-cap structure using monoclonal antibodies to cap-binding proteins","volume":"21","author":"Sonenberg, N.; Trachsel, H.","year":"1982","unstructured":"Sonenberg N, Trachsel H. Probing the function of the eukaryotic 5'-cap structure using monoclonal antibodies to cap-binding proteins. Current Topics in Cellular Reguladon 1982;21:83-4.","journal-title":"Current Topics in Cellular Reguladon"},{"key":"ref_17","first-page":"80","article-title":"Molecular mimicry in virus infection: cross reaction of measles virus phosphoprotein or of herpes simplex virus protein with","volume-title":"human intermediate filament. Proc Nadi Acad Sci","author":"Fujinami, R.S.; Oldstone, M.B.A.; Wroblewska, Z.; Frankel, M.; Koprowski, H.","year":"1983","unstructured":"Fujinami RS, Oldstone MBA, Wroblewska Z, Frankel M, Koprowski H. Molecular mimicry in virus infection: cross reaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filament. Proc Nadi Acad Sci USA 1983;80.2346-50."},{"key":"ref_18","first-page":"1546","article-title":"Infection with vaccinia favours the selection of hybridomas synthesizing autoantibodies against intermediate filaments, one of them crossreacting with the virus haemagglutinin","volume":"31","author":"Dales, S.; Fujinami, R.S.; Oldstone, M.B.A.","year":"1983","unstructured":"Dales S, Fujinami RS, Oldstone MBA. Infection with vaccinia favours the selection of hybridomas synthesizing autoantibodies against intermediate filaments, one of them crossreacting with the virus haemagglutinin. J Immunol 1983;31: 1546-53.","journal-title":"J Immunol"},{"key":"ref_19","series-title":"Abstract 0043","article-title":"Antibodies to cytoskeletal intermediate filaments in rheumatoid arthritis, osteoarthritis and infectious mononucleosis. Proceedings of the 15th intemational congress of rheumatology","author":"NMilani, M.M.; Osung, O.A.; Badakere, S.S.; Chandra, M.; March, R.E.; Holborow, E.J.","year":"1981","unstructured":"NMilani MM, Osung OA, Badakere SS, Chandra M, March RE, Holborow EJ. Antibodies to cytoskeletal intermediate filaments in rheumatoid arthritis, osteoarthritis and infectious mononucleosis. Proceedings of the 15th intemational congress of rheumatology, Paris, 1981. Abstract 0043."},{"key":"ref_20","unstructured":"The February 1985 issue","article-title":"The February 1985 issue"},{"key":"ref_21","unstructured":"THE FEBRUARY 1985 ISSUE CONTAINS THE FOLLOWING PAPERS","article-title":"THE FEBRUARY 1985 ISSUE CONTAINS THE FOLLOWING PAPERS"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.38.3.351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:25:39Z","timestamp":1765005939000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.38.3.351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1985,3,1]]},"published-print":{"date-parts":[[1985,3]]}},"alternative-id":["10.1136\/jcp.38.3.351"],"URL":"https:\/\/doi.org\/10.1136\/jcp.38.3.351","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}